[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640405":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":59,"collaborators":18,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":18,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":18,"enrollmentInfo":70,"targetDuration":18,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":45,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"LITT Group","EXPERIMENTAL","Patients undergoing MR-guided Laser Interstitial Thermal Therapy (LITT) between pre-RT MRI and RT",[13],"Device: LITT",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group 1 (\"No recurrence\")","NO_INTERVENTION","Patients with no recurrence on pre-RT MRI, proceeding directly to RT.",null,{"label":20,"type":16,"description":21,"interventionNames":18},"Control Group 2 (\"No LITT\")","Patients with recurrence but ineligible for LITT, proceeding to another resection or to RT without laser therapy.",[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":18},"DEVICE","LITT","Patients undergoing MR-guided Laser Interstitial Thermal Therapy (LITT) between pre-RT MRI and RT.",[9],[29],{"name":30,"affiliation":31,"role":32},"Philippe Schucht, MD","Inselspital Bern, Department of Neurosurgery","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":18,"email":37},"CONTACT","+41 31 632 00 14","philippe.schucht@insel.ch",{"name":39,"role":35,"phone":40,"phoneExt":18,"email":41},"Alexis P. R. Terrapon, MD","+41 31 66 4 02 39","alexis.terrapon@insel.ch",[43],{"facility":44,"status":45,"city":46,"state":18,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Dep. of Neurosurgery, Bern University Hospital","RECRUITING","Bern","3010","Switzerland","CH",{"type":51,"coordinates":52},"Point",[53,54],7.44744,46.94809,{"lat":54,"lon":53},[57],{"name":58,"role":35,"phone":18,"phoneExt":18,"email":18},"Alexis Terrapon, MD",{"type":60,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100640405","litt-for-ultra-early-gbm-recurrence-100640405",false,"NCT07616986","LITT for Ultra-early GBM Recurrence","Laser Interstitial Thermal Therapy for Ultra-Early, Pre-Radiotherapy Glioblastoma Recurrence","Inclusion Criteria:\n\n* Histologically confirmed glioblastoma, IDH-wildtype, regardless of MGMT status\n* ≥18 years of age\n* CRET\n* Karnofsky Performance Status (KPS) ≥70\n* No contra-indication for radio-chemotherapy\n* Scheduled for adjuvant radio-chemotherapy at University Hospital of Bern\n* Able to provide informed consent\n* No contra-indication for LITT\n* No pregnancy or active breast-feeding\n* No known coagulopathy independent of medication\n* No dissemination or multifocal disease\n* Patients lacking capacity to consent or considered vulnerable (e.g., minors, those under legal protection) are not included.\n\nExclusion Criteria:","ALL","18 Years",{"count":71,"type":72},12,"ESTIMATED","INTERVENTIONAL",[75],"NA","Glioblastoma (GBM) remains aggressive despite standard therapy (surgery (CRET) + RT\u002FCT). Over 40% of patients develop recurrence between surgery and pre-RT MRI, with median overall survival (OS) of 13.3m and 24.4m for patients with and without recurrence in pre-RT MRI, respectively. Reoperation is avoided as it delays adjuvant therapy.\n\nLITT offers a minimally invasive alternative that may:\n\n* Treat recurrence without delaying RT\u002FCT\n* Potentially sensitize tumors to subsequent therapy This study tests if LITT can be practically integrated within the critical 1-week window between pre-RT MRI and radiotherapy initiation, maintaining the adjuvant schedule.",[78,79],"Glioblastoma (GBM)","Glioblastoma - Category",[25,81,82,83,84,85],"Laser Interstitial Thermal Therapy","ultra-early recurrence","GMB","GMB recurrence","GMB ultra-early recurrence","2026-05-28",{"date":88,"type":89},"2026-06-01","ACTUAL",{"date":91,"type":89},"2026-02-06",{"date":93,"type":72},"2028-01-31",{"name":5,"class":6},1]