[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531962":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":29,"responsibleParty":61,"collaborators":65,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Palermo","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Celiac Disease Children",null,"Pediatric patients affected by newly diagnosed CD according to the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria will be evaluated before the start of gluten-free diet and after 6 months of gluten-free diet.",[13],"Behavioral: Gluten-free diet",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"BEHAVIORAL","Gluten-free diet","Pediatric patients affected by newly diagnosed Celiac Disease (CD) according to the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria will start a gluten-free diet (GFD), as normally expected for all CD patients. The assessment of adherence to the GFD will be carried out through the monthly compilation, by the children and\u002For their parents, of a specifically created and validated questionnaire.\n\nBefore and after the start of GFD enrolled patients will undergo an abdominal ultrasound to establish the presence and degree of hepatic steatosis.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Aurelio Seidita, MD","CONTACT","00390916802764","aurelio.seidita@unipa.it",{"name":27,"role":23,"phone":24,"phoneExt":10,"email":28},"Antonio Carroccio, MD","antonio.carroccio@unipa.it",[30,50],{"facility":31,"status":32,"city":33,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Gastroenterological Paediatrics, Children's Hospital \"G. Di Cristina\"","RECRUITING","Palermo","90127","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],13.3636,38.1166,{"lat":41,"lon":40},[44,48],{"name":45,"role":23,"phone":46,"phoneExt":10,"email":47},"Francesca Cavataio, MD","00390916666220","pediatria1@arnascivico.it",{"name":49,"role":23,"phone":46,"phoneExt":10,"email":47},"Maria Letizia Lo Spalluti, MD",{"facility":51,"status":32,"city":33,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"General Pediatrics Unit, Children's Hospital \"G. Di Cristina\"",{"type":38,"coordinates":53},[40,41],{"lat":41,"lon":40},[56,60],{"name":57,"role":23,"phone":58,"phoneExt":10,"email":59},"Salvatore Accomando, MD","00390916666245","clinicapediatrica.ped@arnascivico.it",{"name":10,"role":23,"phone":58,"phoneExt":10,"email":10},{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Aurelio Seidita","Assistant Professor",[66,68],{"name":67,"class":6},"ARNAS Civico Di Cristina Benfratelli Hospital",{"name":69,"class":6},"Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello","100531962","liver-steatosis-in-pediatric-cd-patients-100531962",false,"NCT06206616","Liver Steatosis in Pediatric CD Patients","Liver Steatosis in Pediatric Celiac Disease Patients: Exploring the Epidemiological and Pathophysiological Features of an Underestimated Condition","Inclusion Criteria:\n\n* Age \\>1 and \\\u003C14 years\n* Celiac Disease diagnosis according European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria\n\nExclusion Criteria:\n\n* age \\\u003C1 and \\>14 years;\n* self-exclusion of gluten\u002Fwheat from the diet and refusal to reintroduce it, for diagnostic purposes, before entering the study;\n* bacterial and\u002For parasitic infections;\n* diagnosis of chronic inflammatory intestinal diseases and other organic pathologies affecting the digestive system (for example, serious liver diseases), nervous system diseases, immunological deficits and impairments that limit physical activity;\n* diagnosis of cancer\n* patients undergoing chemotherapy and\u002For radiotherapy.","ALL","1 Year","14 Years",{"count":81,"type":82},91,"ESTIMATED","OBSERVATIONAL","Celiac disease (CD) is an autoimmune enteropathy triggered by the intake of gluten, characterized by a genetic predisposition. Although, CD is often associated with malabsorption symptoms, a growing number of affected subjects are overweight or frankly obese. One of the conditions that is most frequently detected in pauci\u002Fasymptomatic subjects is an increase in transaminases, which often regresses completely after the start of GFD.\n\nMore recently, a specific liver disorder has shown a certain relevance in adult patients suffering from CD, so much so that the European Society for the Study of Coeliac Disease (ESsCD) has cited it among the possible comorbidities which should be screened in CD subjects: Non-Alcoholic Fatty Liver Disease (NAFLD).\n\nIn adults, a non-random association between CD and NAFLD has been demonstrated, showing a CD prevalence rate of 2-14% among patients with NAFLD. Few studies have focused on this same aspect in pediatric age, reporting contrasting data.\n\nSeveral factors have been advocated as putative responsible of association between CD and NAFLD: dietary imbalances, intestinal mucosa permeability impairment, alterations of the intestinal microbiota.\n\nThe objectives of this study are:\n\n1. define, retrospectively, the prevalence of NAFLD in a pediatric population affected by CD and study its possible association with GFD.\n2. define the possible role of the intestinal permeability alteration and\u002For the intestinal mucosa damage and\u002For the proinflammatory status in the development of NAFLD in children affected by CD.",[86,87],"Celiac Disease in Children","Non-Alcoholic Fatty Liver Disease",[89,87,90,91,92],"Celiac Disease","Intestinal Permeability","Inflammatory Cytokines","Children","2026-04-27",{"date":95,"type":96},"2026-05-01","ACTUAL",{"date":98,"type":82},"2027-11-01",{"date":100,"type":82},"2028-09-30",{"name":5,"class":6},2]