[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591904":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":19,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Transplant",null,"Patients with liver-limited unresectable perihilar cholangiocarcinoma with no other non-oncological contraindication to liver transplantation",[13],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},"Vincenzo Mazzaferro, MD, PhD","CONTACT","0223902760","+39","vincenzo.mazzaferro@istitutotumori.mi.it",[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Fondazione IRCCS Istituto Nazionale Tumori di Milano","RECRUITING","Milan","Michigan","20133","Italy","IT",{"type":29,"coordinates":30},"Point",[31,32],9.18951,45.46427,{"lat":32,"lon":31},[35,39,41,44,46],{"name":36,"role":15,"phone":37,"phoneExt":17,"email":38},"Marianna Maspero","0223904066","marianna.maspero@istitutotumori.mi.it",{"name":14,"role":40,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":42,"role":43,"phone":10,"phoneExt":10,"email":10},"Carlo Sposito, MD","SUB_INVESTIGATOR",{"name":45,"role":43,"phone":10,"phoneExt":10,"email":10},"Marianna Maspero, MD",{"name":47,"role":43,"phone":10,"phoneExt":10,"email":10},"Marco Bongini, MD, Ms",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100591904","liver-transplantation-for-unresectable-perihilar-cholangiocarcinoma-100591904",false,"NCT06986486","Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma","Neoadjuvant Chemotherapy and Stereotactic Body Radiation Therapy Followed by Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma: pCOLA","pCOLA","Inclusion Criteria:\n\n* Diagnosis of unresectable peripheral cholangiocarcinoma arising one centimeter or more above the superior pancreatic margin, with tumor diameter ≤ 3 cm, diagnosed by:\n* Transcatheter biopsy or brush cytology\n* CA-19.9 \\> 100 mg\u002Fml and\u002For a mass on cross-sectional imaging with a malignant appearing stricture on cholangiography\n* Biliary ploidy by FISH with a malignant appearing stricture on cholangiography\n* Age between 18 years and 70 years\n* Absence of intra- and extrahepatic metastases\n* Absence of lymph-nodal metastases at any site\n* Biliary stenting of all liver districts\n* No contraindications to liver transplantation\n* No concomitant malignancies or history of other malignancies in the previous 5 years\n* Written informed consent\n\nExclusion Criteria:\n\n* Intrahepatic cholangiocarcinoma\n* Uncontrolled infection\n* Concomitant malignancies or history of other malignancies in the previous 5 years","ALL","18 Years","70 Years",{"count":62,"type":63},8,"ESTIMATED","OBSERVATIONAL","This is multicentric, single-arm, observational, investigator-drive study investigating the efficacy of liver transplantation after successful downstaging\u002Fdisease control of unresectable perihilar cholangiocarcinoma using chemotherapy +\u002F- immunotherapy and stereotactic body radiation therapy (SBRT).",[67,68],"Perihilar Cholangiocarcinoma","Klatskin Tumor",[70,71,72],"liver transplantation","stereotactic body radiation therapy","downstaging","2025-05-15",{"date":75,"type":76},"2025-05-23","ACTUAL",{"date":78,"type":63},"2025-06-01",{"date":80,"type":63},"2030-01-01",{"name":5,"class":6},1]