[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543440":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":36,"responsibleParty":56,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":20,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":20,"enrollmentInfo":72,"targetDuration":20,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"High Carbohydrate Diet","EXPERIMENTAL","1. First scan: after an overnight fast of at least 8 hours using standard radiation oncology CT scan with contrast for treatment planning.\n2. Standardized high-carb meal such as 8 ounces of Ensure® nutritional protein shake or a similar meal, immediately following first scan and consumed within 15 minutes.\n3. Second scan: within 1 hour of ingestion of the high-carb meal using similar settings to those used in the first scan except for contrast use.\n4. Third CT scan at least 4 hours (but no more than 5 hours) after ingestion of high-carb diet on the same day utilizing same set up used in first scan with exception for the use of contrast.",[13],"Dietary Supplement: Standardized high-carbohydrate meal",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","Standardized high-carbohydrate meal","8 ounces of Ensure® nutritional protein shake or a similar meal",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Susannah Ellsworth, MD","UPMC Hillman Cancer Center","PRINCIPAL_INVESTIGATOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Samantha Demko, BSN","CONTACT","412-623-1400","albesl@upmc.edu",{"name":33,"role":29,"phone":34,"phoneExt":20,"email":35},"Brieanna Marino, MS","412-647-8258","rowlesbm@upmc.edu",[37],{"facility":24,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Pittsburgh","Pennsylvania","15232","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-79.99589,40.44062,{"lat":48,"lon":47},[51,53,55],{"name":52,"role":29,"phone":20,"phoneExt":20,"email":20},"Samantha Demko",{"name":54,"role":29,"phone":20,"phoneExt":20,"email":20},"Brieanna Marino",{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"type":25,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Susannah Ellsworth","Clinical Associate Professor",[60],{"name":61,"class":62},"American College of Radiation Oncology","UNKNOWN","100543440","liver-volume-variation-effect-on-sbrt-planning-and-delivery-for-upper-abdominal-malignancies-100543440",false,"NCT06355895","Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies","The Effect of Liver Volume Variation on Stereotactic Body Radiation Therapy (SBRT) Planning and Delivery for Upper Abdominal Malignancies","Inclusion Criteria:\n\n• Have primary upper abdominal (pancreatic, bile duct, liver) cancer or upper abdominal metastases (liver, adrenal, upper abdominal lymph nodes) planned to undergo SBRT.\n\nExclusion Criteria:\n\n* Had prior Radiation Therapy to the liver\n* Contraindication to receipt of iodinated IV contrast for CT (such as renal insufficiency or allergy that cannot be overcome by premedication)\n* Pregnancy\u002Flactation OR woman of childbearing potential who is unable or unwilling to use adequate contraception during Radiation Therapy.\n* Inability to fast.","ALL","18 Years",{"count":73,"type":74},17,"ESTIMATED","INTERVENTIONAL",[77],"NA","Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting\u002Ffed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT.",[80],"Upper Abdominal Malignancies",[82,83],"Stereotactic Body Radiation Therapy (SBRT)","Four-Dimensional Computed Tomography","2026-06-08",{"date":86,"type":87},"2026-06-11","ACTUAL",{"date":89,"type":87},"2024-05-16",{"date":91,"type":74},"2028-03-31",{"name":5,"class":6},1]