[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619889":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":48,"collaborators":51,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":18,"enrollmentInfo":71,"targetDuration":18,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":85,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"First Hospital of China Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LLM-Enabled Intervention Group","ACTIVE_COMPARATOR","LLM-enabled community physicians delivered integrated, guideline-based management",[13],"Other: LLM-Enabled Co-management",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care Control Group","NO_INTERVENTION","Community physicians provided routine care according to local primary health service standards",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"LLM-Enabled Co-management","The intervention is a LLM-enabled, community-based integrated management strategy for cardiometabolic multimorbidity. The LLM system functions as the central intelligence layer, integrating multi-condition clinical information, delivering real-time decision support, coordinating care workflows, and facilitating continuous patient engagement. Within this LLM-enabled framework, community physicians-after standardized training-serve as the core executors of care, delivering guideline-based pharmacologic treatment, lifestyle counseling, and structured monitoring of coexisting cardiometabolic conditions. Policy-aligned performance incentives are used to support physician engagement and implementation fidelity, without altering medication access or underlying clinical protocols.\n\nThe LLM-enabled intervention is implemented through the HyperMind system, an integrated platform that simultaneously supports clinicians, patients, and health-system oversight.",[9],[25],{"name":26,"affiliation":5,"role":27},"Yingxian Sun, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Xiaofan Guo, PhD","CONTACT","+86 13842078178","guoxiaofan1986@hotmail.com",[35],{"facility":36,"status":18,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":18},"The First Hospital of China Medical University","Shenyang","Liaoning","110001","China","CN",{"type":43,"coordinates":44},"Point",[45,46],123.43278,41.79222,{"lat":46,"lon":45},{"type":27,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Yingxian Sun","Chief of Department of Cardiology in First Hospital of China Medical University",[52,54,56,59],{"name":53,"class":6},"Beijing Chao Yang Hospital",{"name":55,"class":6},"Zhejiang University",{"name":57,"class":58},"Shandong Provincial Hospital","OTHER_GOV",{"name":60,"class":6},"Cangzhou Central Hospital","100619889","llm-comanage-large-language-model-enabled-co-management-of-hypertension-diabetes-and-dyslipidemia-100619889",false,"NCT07350486","LLM-CoManage: Large Language Model-Enabled Co-Management of Hypertension, Diabetes, and Dyslipidemia","A Cluster-Randomized Trial of Large Language Model-Enabled Coordinated Management for Hypertension, Diabetes, and Dyslipidemia in Community Settings (LLM-CoManage Trial)","LLM-CoManage","Inclusion Criteria:\n\nParticipating communities must meet all of the following criteria:\n\n* Have a designated community physician responsible for primary care who is capable of using a smartphone with stable internet access for clinical communication and LLM-assisted management;\n* No plan for administrative merger or restructuring within the next three years;\n* Located at least 2 kilometers away from adjacent participating communities (to minimize contamination between clusters).\n\nEligible participants must fulfill all of the following conditions:\n\n* Aged 40 years or older;\n* Uncontrolled hypertension, defined as systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg;\n* Coexisting diabetes (HbA1c ≥ 7.0%) or coexisting dyslipidemia (LDL-C ≥ 3.4 mmol\u002FL\\[130 mg\u002FdL\\]);\n* Able to use a smartphone independently or with assistance from family members;\n* Has resided in the participating community for at least 6 months;\n* Has no plan to relocate in the next 3 years;\n* Enrolled in basic medical insurance for urban and rural residents, employee medical insurance, or the New Rural Cooperative Medical Scheme;\n* Not currently pregnant or planning pregnancy during the study period;\n* Free from malignant tumors and deemed to have a life expectancy of at least 3 years, as judged by study physicians;\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:No specific exclusion criteria.","ALL","40 Years",{"count":72,"type":73},6800,"ESTIMATED","INTERVENTIONAL",[76],"NA","This study aims to evaluate the effectiveness of a large language model (LLM)-supported, community-based integrated management model in improving cardiometabolic multimorbidity control among adults with hypertension and coexisting diabetes or dyslipidemia. Adopting an interventional study design, eligible patients will be recruited to compare the disease control indicators between LLM-assisted management and conventional management, so as to verify the effectiveness and safety of the former.",[79,80,81],"Hypertension","Diabetes","Dyslipidemia",[83,84],"Large Language Model","Co-Management","NOT_YET_RECRUITING","2026-05-09",{"date":88,"type":89},"2026-05-13","ACTUAL",{"date":91,"type":73},"2026-06-15",{"date":93,"type":73},"2027-12-31",{"name":5,"class":6},1]