[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636171":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":11,"centralContacts":15,"locations":22,"responsibleParty":39,"collaborators":41,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":10,"enrollmentInfo":54,"targetDuration":57,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":71,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"The University of Queensland","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Sepsis with hypotension or signs of hypoperfusion admitted to ICU",null,[12],{"name":13,"affiliation":5,"role":14},"Hideaki Nonaka, Dr","STUDY_DIRECTOR",[16,20],{"name":13,"role":17,"phone":18,"phoneExt":10,"email":19},"CONTACT","+61 449967910","hideaki54nonaka@gmail.com",{"name":21,"role":17,"phone":10,"phoneExt":10,"email":10},"Nonaka",[23],{"facility":24,"status":10,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"The Prince Charles Hospital","Chermside","Queensland","4032","Australia","AU",{"type":31,"coordinates":32},"Point",[33,34],153.03062,-27.38472,{"lat":34,"lon":33},[37,38],{"name":13,"role":17,"phone":18,"phoneExt":10,"email":19},{"name":21,"role":17,"phone":10,"phoneExt":10,"email":10},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[42],{"name":43,"class":6},"Queen Mary Hospital, Hong Kong","100636171","load-incorporating-cardiac-assessment-by-echocardiography-in-patients-with-sepsis-liaise-study-100636171",false,"NCT07562217","Load Incorporating Cardiac Assessment by Echocardiography In Patients With SEpsis (LIAISE Study)","Load Incorporating Cardiac Assessment by Echocardiography In Patients With SEpsis: a Prospective Observational Study (LIAISE Study)","LIAISE","Inclusion Criteria:\n\n1. Adults ≥ 18 years old.\n2. Clinically suspected of defined sepsis\n3. Sepsis-induced hypotension or hypoperfusion (arterial or venous blood lactate ≥2.0 mmol\u002FL OR mean artery pressure ≤65 mmHg over 30 mins OR at least one vasoactive or inotropic agent administered).\n4. At least one dose of an IV antimicrobial has been commenced.\n\nExclusion Criteria:\n\n1. Suspected or confirmed pregnancy.\n2. Any severe concomitant diseases with limited life expectancy \\\u003C30 days.","ALL","18 Years",{"count":55,"type":56},200,"ESTIMATED","2 Years","OBSERVATIONAL","The LIAISE study is a prospective observational study comparing the performance of load-incorporating echocardiographic parameters and conventional parameters in predicting adverse events among adult patients presenting to the ICU with sepsis. It will be conducted in hospitals in Australia, Hong Kong, South Africa, and Canada, with 199 patients recruited over 2 years. All included patients will receive an regular echocardiographic assessment and their haemodynamic parameters will be simultaneously recorded. Participants will be followed for up to 1 year after enrolment. Load incorporating parameters will be derived from regularly obtained echocardiography and haemodynamic data during offline analysis. The predictive value of cardiac parameters will be evaluated based on their statistical association with clinical outcomes.",[61],"Sepsis",[63,64,65,66,67,68,69,70],"sepsis","echocardiography","strain","speckle-tracking","myocardial work","ICU","echocardiogram","load-independent","NOT_YET_RECRUITING","2026-04-25",{"date":74,"type":75},"2026-05-01","ACTUAL",{"date":74,"type":56},{"date":78,"type":56},"2028-11-30",{"name":5,"class":6},1]