[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644795":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":38,"locations":48,"responsibleParty":60,"collaborators":30,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":30,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":51,"whyStopped":30,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Marmara University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","PLACEBO_COMPARATOR","Participants receive an inferior alveolar nerve block followed by a submucosal saline injection prior to endodontic treatment.",[13],"Drug: Saline (0.9%, sterile, for infusion)",{"label":15,"type":16,"description":17,"interventionNames":18},"Submucosal Dexamethasone","EXPERIMENTAL","Participants receive an inferior alveolar nerve block followed by submucosal dexamethasone administration prior to endodontic treatment.",[19],"Drug: Dexamethasone",{"label":21,"type":16,"description":22,"interventionNames":23},"Intraligamentary Dexamethasone","Participants receive an inferior alveolar nerve block followed by intraligamentary dexamethasone administration prior to endodontic treatment.",[19],[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Saline (0.9%, sterile, for infusion)","Normal saline is administered submucosally following inferior alveolar nerve block in patients with symptomatic irreversible pulpitis undergoing root canal treatment.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Dexamethasone","Dexamethasone (8 mg\u002F2 mL) is administered submucosally following inferior alveolar nerve block in patients with symptomatic irreversible pulpitis undergoing root canal treatment.",[15],{"type":26,"name":32,"description":36,"armGroupLabels":37,"otherNames":30},"Dexamethasone (8 mg\u002F2 mL) is administered intraligamentarily following inferior alveolar nerve block in patients with symptomatic irreversible pulpitis undergoing root canal treatment.",[21],[39,44],{"name":40,"role":41,"phone":42,"phoneExt":30,"email":43},"Elif İrem Altıntaş, Research Assistant","CONTACT","+905425491411","eialtintas@icloud.com",{"name":45,"role":41,"phone":46,"phoneExt":30,"email":47},"Ayşe Karadayı, Assistant Professor","+905330527343","ayse.karadayi@marmara.edu.tr",[49],{"facility":50,"status":51,"city":52,"state":30,"zip":30,"country":53,"countryCode":30,"cosmosGeoPoint":54,"geoPoint":59,"contacts":30},"Marmara University Faculty of Dentistry","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":55,"coordinates":56},"Point",[57,58],28.94966,41.01384,{"lat":58,"lon":57},{"type":61,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100644795","local-dexamethasone-administration-in-symptomatic-irreversible-pulpitis-100644795",false,"NCT07672873","Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis","Comparison of the Effects of Submucosal and Intraligamentary Dexamethasone Administration on Anesthetic Success and Pain Control in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial","SIPDEX","Inclusion Criteria:\n\n* Patients aged 18 to 65 years.\n* ASA I or ASA II systemic health status.\n* Symptomatic irreversible pulpitis in a mandibular molar tooth.\n* Positive response to pulp sensibility tests.\n* Preoperative pain score greater than 54 mm on the Heft-Parker Visual Analog Scale (HP-VAS).\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or lactation.\n* Allergy or contraindication to articaine, dexamethasone, or study-related medications.\n* Use of analgesics, anti-inflammatory drugs, or antibiotics within the previous 12 hours.\n* Presence of periapical radiolucency or diagnosis of pulpal necrosis.\n* Significant systemic disease (ASA III or higher).\n* Inability to complete pain assessment forms or follow study procedures.",true,"ALL","18 Years","65 Years",{"count":75,"type":76},84,"ESTIMATED","INTERVENTIONAL",[79],"NA","Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth. Failure to achieve profound anesthesia may result in increased intraoperative pain and patient discomfort. Corticosteroids have been suggested as adjunctive agents to improve pain control and reduce inflammatory responses; however, the influence of different local administration techniques on anesthetic success and postoperative pain remains unclear.\n\nThe aim of this randomized controlled clinical trial is to compare the effects of submucosal and intraligamentary dexamethasone administration on anesthetic success and pain control in patients with symptomatic irreversible pulpitis. A total of 84 participants requiring root canal treatment of mandibular first or second molars diagnosed with symptomatic irreversible pulpitis will be randomly allocated to one of three groups: (1) inferior alveolar nerve block (IANB) followed by submucosal saline injection (control group), (2) IANB followed by submucosal dexamethasone injection, and (3) IANB followed by intraligamentary dexamethasone injection.\n\nAll participants will receive standardized endodontic treatment under local anesthesia. The primary outcome measure is anesthetic success during access cavity preparation and pulp extirpation. Secondary outcome measures include postoperative pain intensity at 6, 12, 24, 48, and 72 hours, and postoperative analgesic consumption. The results of this study may provide evidence regarding the effectiveness of different local dexamethasone administration techniques and contribute to improved pain management strategies in endodontic practice.",[82,83],"Symptomatic Irreversible Pulpitis (SIP)","Dental Pain",[85,32,86,87,88,89,90,91,92],"Inferior alveolar nerve block","Submucosal injection","Intraligamentary injection","Symptomatic irreversible pulpitis","Endodontic treatment","Postoperative pain","Heft-Parker Visual Analog Scale","HP-VAS","2026-06-26",{"date":95,"type":96},"2026-06-29","ACTUAL",{"date":98,"type":96},"2026-06-15",{"date":100,"type":76},"2026-12-18",{"name":5,"class":6},1]