[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518185":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":39,"locations":49,"responsibleParty":71,"collaborators":73,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":29,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":29,"enrollmentInfo":85,"targetDuration":29,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":52,"whyStopped":29,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,15,19],{"label":9,"type":6,"description":10,"interventionNames":11},"Post- COVID 19 POTS patients","Inflammatory markers IL-6,Cytokines (IL-17, and IFN-ɣ), Autonomic symptoms assessment questionnaire (COMPASS 31): In post-COVID-19 POTS (cases).",[12,13,14],"Diagnostic Test: IL-6","Diagnostic Test: cytokines (IL-17, and IFN-ɣ)","Behavioral: Compass 31",{"label":16,"type":6,"description":17,"interventionNames":18},"POTS patients","Inflammatory markers IL-6,Cytokines (IL-17, and IFN-ɣ), Autonomic symptoms assessment questionnaire (COMPASS 31):Gender, age, and BMI-matched: patients with diagnosis of POTS",[12,13,14],{"label":20,"type":6,"description":21,"interventionNames":22},"Post- COVID 19 POTS patients with Controls","Inflammatory markers IL-6,Cytokines (IL-17, and IFN-ɣ), Autonomic symptoms assessment questionnaire (COMPASS 31):Gender, age, and BMI-matched: Controls are :COVID-19 infected without sequelae",[12,13,14],[24,30,34],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DIAGNOSTIC_TEST","IL-6","Compare IL-6 level , as a marker of inflammation in all the 3 groups:\n\n* POTS patients\n* post-COVID-19 POTS\n* gender, age, and BMI-matched controls, with history of COVID-19 infection without sequelae.",[16,9,20],null,{"type":25,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"cytokines (IL-17, and IFN-ɣ)","Compare Proinflammatory cells and its secreted cytokines (IL-17, and IFN-ɣ) in all the 3 groups:\n\n* POTS patients\n* post-COVID-19 POTS\n* gender, age, and BMI-matched controls, with history of COVID-19 infection without sequelae",[16,9,20],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":29},"BEHAVIORAL","Compass 31","Autonomic symptoms assessment questionnaire (COMPASS 31), in post-COVID-19 POTS and compare with POTS patients",[16,9,20],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":29,"email":44},"Marwa Mohamed, Phd","CONTACT","6159702384","marwa.mohamed@vumc.org",{"name":46,"role":42,"phone":47,"phoneExt":29,"email":48},"Cyndya Shibao, MD","615-322-3447","cyndya.shibao@vumc.org",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Cyndya Shibao","RECRUITING","Nashville","Tennessee","37027","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-86.78444,36.16589,{"lat":62,"lon":61},[65,68],{"name":66,"role":42,"phone":29,"phoneExt":29,"email":67},"Cyndya Shibao, RN","cyndya.shibao@vanderbilt.edu",{"name":69,"role":70,"phone":29,"phoneExt":29,"email":29},"Cyndya A Shibao, MD","PRINCIPAL_INVESTIGATOR",{"type":70,"investigatorFullName":46,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Associate Professor",[74],{"name":75,"class":6},"American Heart Association","100518185","long-covid-immune-profiling-100518185",false,"NCT06027255","Long COVID Immune Profiling","Inclusion Criteria:\n\n* Subjects will be 18 years or older, men and women.\n* History of confirmed COVID-19 infection (positive contact and symptoms, antigen test or PCR).\n* POTS will be defined as the presence of orthostatic tachycardia (\\>30 bpm) and chronic (\\>3 months) pre-syncopal symptoms.\n* Post-COVID-19 POTS will be defined as the presence of orthostatic tachycardia (\\>30 bpm) and chronic (\\>3 months) pre-syncopal symptoms. Symptoms occurred within 2 months after COVID infection and persistent until enrollment in the study.\n\nExclusion Criteria:\n\n* Individuals with a history of physician diagnosed myocardial infarction, angina, heart failure, stroke, or transient ischemic attack, or who had undergone an invasive procedure for CVD (coronary artery bypass graft, angioplasty, valve replacement, pacemaker placement or other vascular surgeries).\n* Inability to comply with the protocol, e.g. uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study.\n* Chronic use of steroids, anti-IL6 (omalizumab), anti-TNF-alpha, other immunosuppressants.\n* Chronic use of NSAID. Should not enroll if taking without one week prior to blood sampling.\n* Treatment with plasmapheresis, IVIG or other immune modulator",true,"ALL","18 Years",{"count":86,"type":87},150,"ESTIMATED","INTERVENTIONAL",[90],"NA","Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation.\n\nPreliminary data from the studies shows, that post-COVID-19 POTS patients have reduced parasympathetic (PNS) function. Given that the PNS protects against inflammation, this clinical trial aims to prove that post-COVID-19 POTS is caused by reduced PNS activity, which in turn, contributes to persistent inflammation, orthostatic intolerance, and OI symptoms.\n\nThe study will evaluate immune cell activation in post-COVID-19 POTS and patients with history of COVID-19 infection without sequelae and correlate this with the degree of decreased PNS activity.",[93,94,95],"Long COVID","POTS - Postural Orthostatic Tachycardia Syndrome","Autonomic Dysfunction",[97,98,99,93,100],"SARS-CoV-2 infection","POTS","Orthostatic Intolerance","Long hauler COVID infection","2025-12-07",{"date":103,"type":104},"2025-12-15","ACTUAL",{"date":106,"type":104},"2024-04-24",{"date":108,"type":87},"2027-07-01",{"name":5,"class":6},1]