[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601331":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":42,"locations":48,"responsibleParty":67,"collaborators":11,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":11,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":11,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":96,"whyStopped":11,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Universiti Sains Malaysia","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate intensity eccentric cycling (MI-ECC)","EXPERIMENTAL",null,[13],"Other: Moderate-intensity eccentric cycling",{"label":15,"type":10,"description":11,"interventionNames":16},"High intensity eccentric cycling (HI-ECC)",[17],"Other: High-intensity eccentric cycling",{"label":19,"type":20,"description":11,"interventionNames":21},"Moderate intensity concentric cycling (MI-CON)","ACTIVE_COMPARATOR",[22],"Other: Moderate-intensity concentric cycling",[24,30,36],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Moderate-intensity eccentric cycling","* This group will perform eccentric cycling exercise twice per week for ten weeks using the Cyclus2 standard eccentric ergometer.\n* The intensity will start at 60% of the peak power output (PPO) of the incremental concentric cycling test.\n* The intensity will progressively increase by 5% of PPO every 2 weeks (60%-80% PPO).",[9],[29],"MI-ECC",{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"High-intensity eccentric cycling","* This group will perform eccentric cycling exercise twice per week for ten weeks using the Cyclus2 standard eccentric ergometer.\n* The intensity will start at 80% of the peak power output (PPO) of the incremental concentric cycling test.\n* The intensity will progressively increase by 5% of PPO every 2 weeks (80%-100% PPO).",[15],[35],"HI-ECC",{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"Moderate-intensity concentric cycling","* This group will perform concentric cycling exercise twice per week for ten weeks using the Lode Excalibur sport ergometer.\n* The intensity will start at 60% of the peak power output (PPO) of the incremental concentric cycling test.\n* The intensity will progressively increase by 5% of PPO every 2 weeks (60%-80% PPO).",[19],[41],"MI-CON",[43],{"name":44,"role":45,"phone":46,"phoneExt":11,"email":47},"Syamimi Shamsuddin","CONTACT","+6045622024","syamimi.s@usm.my",[49],{"facility":50,"status":11,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Cardio and Muscle Function Laboratory, Pusat Perubatan USM Bertam","Kepala Batas","Pulau Pinang","13200","Malaysia","MY",{"type":57,"coordinates":58},"Point",[59,60],100.4265,5.51707,{"lat":60,"lon":59},[63],{"name":64,"role":45,"phone":65,"phoneExt":11,"email":66},"Rabiatul Adawiah Abdul Rahman","+60193709614","rabiatuladawiah3105@gmail.com",{"type":68,"investigatorFullName":64,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100601331","long-term-benefits-of-eccentric-cycling-exercise-in-patients-with-type-2-diabetes-mellitus-100601331",false,"NCT07109102","Long-Term Benefits of Eccentric Cycling Exercise in Patients With Type 2 Diabetes Mellitus","Exploring Long-Term Benefits of Eccentric Cycling Exercise on Physiological Responses, Exercise Capacity, and Quality of Life in Patients With Type 2 Diabetes Mellitus","Inclusion Criteria:\n\n* Male diagnosed with T2DM\n* Age 30 - 60 years old\n* Height ≥155cm (To ensure proper ergonomics, comfort and safety during cycling)\n* HbA1C level between 6-8%\n* No resistance exercise for ≤ 3 months before participating in the current study.\n* Physical inactivity (moderate to vigorous exercise ≤60 minutes weekly based on International Physical Activity Questionnaires-Short Form (IPAQ-SF))\n\nExclusion Criteria:\n\n* Acute illness or any foot ulcer, diabetic ulcer, retinopathy, kidney, musculoskeletal, cardiovascular, or neurological disorder that could impair exercise performance or pose a risk to participants during exercise.\n* Insulin injection","MALE","30 Years","60 Years",{"count":81,"type":82},30,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of this interventional study is to evaluate the long-term benefits of eccentric (ECC) cycling exercise on physiological responses, exercise capacity, and quality of life (QoL) in patients with type 2 diabetes mellitus (T2DM). The main questions it aims to answer are:\n\n* What are the effects of ECC cycling compared to concentric (CON) cycling on physiological responses, exercise capacity, and QoL in patients with T2DM?\n* What are the differential effects of moderate- and high-intensity ECC cycling compared to CON cycling on physiological responses, exercise capacity, and QoL in patients with T2DM?\n\nResearchers will compare moderate- and high-intensity ECC cycling to CON cycling (conventional cycling) to see if ECC cycling can be a viable alternative or complement to existing exercise protocols for managing T2DM.\n\nParticipants will:\n\n* Undergo pre-, mid-, and post-intervention assessment\n* Perform either moderate- or high-intensity ECC cycling or moderate intensity CON cycling according to group randomisation by the researcher.\n* Start with two familiarisation sessions prior to the actual cycling training.\n* Perform cycling exercise twice per week for 10 weeks.",[88],"Type 2 Diabetes Mellitus (T2DM)",[90,91,92,93,94,95],"Eccentric cycling","eccentric exercise","exercise capacity","quality of life","physiological responses","Type 2 diabetes mellitus","NOT_YET_RECRUITING","2025-07-30",{"date":99,"type":100},"2025-08-07","ACTUAL",{"date":102,"type":82},"2025-08",{"date":104,"type":82},"2026-08",{"name":5,"class":6},1]