[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633957":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":28,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":10,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort of Children with Moderate-to-Severe Traumatic Brain Injury Admitted to Intensive Care",null,"Patients who suffered moderate to severe head trauma during childhood requiring hospitalization in the intensive care unit at the Femme Mère Enfant hospital in Lyon, included in the Endoc TC study Telephone interview to obtain current measurements and endocrine symptoms. Extraction of data from initial Endoc TC study via Easily, secure patient software used by investigators' team.",[13],"Other: Telephone questionnaire",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Telephone questionnaire","After receiving parental non-opposition for minor patients and non-opposition for adults patients, a structured telephone questionnaire is conducted. The interview is not recorded. It lasts approximately 15 minutes.",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Kevin PERGE, M.D.","CONTACT","+33 4 72 11 88 90","kevin.perge@chu-lyon.fr",{"name":26,"role":22,"phone":23,"phoneExt":10,"email":27},"Camille BEDUNEAU","camille.beduneau@chu-lyon.fr",[29],{"facility":30,"status":10,"city":31,"state":10,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Service d'Endocrinologie, Diabétologie et Métabolisme Pédiatriques, Hôpital Femme-Mère-Enfant de Lyon","Bron","69677","France","FR",{"type":36,"coordinates":37},"Point",[38,39],4.91303,45.73865,{"lat":39,"lon":38},[42,43,44],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":26,"role":22,"phone":23,"phoneExt":10,"email":27},{"name":21,"role":45,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100633957","long-term-follow-up-of-pituitary-and-hypothalamic-dysfunction-in-children-who-have-suffered-moderate-to-severe-head-trauma-included-in-the-endoc-tc-cohort-100633957",false,"NCT07533435","Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort","ENDOC TC 2","Inclusion Criteria:\n\n* Consent of the child if under 18 years of age and no objection from both parents, or no objection from the adult patient\n* Patients included in the Princeps Endoc TC study in Lyon\n\n  * Patients who have suffered a traumatic brain injury\n  * Children aged 2 months to 16 years inclusive\n  * Admitted to pediatric intensive care\n  * Initial Glasgow Coma Scale score between 3 and 12, regardless of the mechanism of head injury\n  * Informed consent signed by parents\n\nExclusion Criteria:\n\n* Patient deceased since the end of Endoc TC study","ALL",{"count":57,"type":58},90,"ESTIMATED","OBSERVATIONAL","The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.\n\nStudies conducted in adults have shown an anterior pituitary deficit in 28% to 68% of patients with TBI. The variability of these studies does not currently allow for standardization of the management of these children in either the acute or late phases.\n\nSeveral studies, including a Lyon-based study called Endoc TC (Ref. Clinical Trials: NCT01250132), have aimed to investigate the association between anterior pituitary deficits in the acute phase and those identified a few months after the trauma.\n\nSince then, few studies have been conducted more than five years after the trauma to study its pituitary consequences.\n\nTo date, the investigators have sought to study the long-term prevalence of pituitary and hypothalamic dysfunction in patients who suffered moderate to severe head trauma during childhood, specifically patients included in the initial Endoc TC study in Lyon.\n\nTo this end, the main objective is to determine the current height of these patients and whether there are any associated growth delays or other clinical signs that may suggest the presence of a pituitary or hypothalamic hormone deficiency.\n\nThis study consists of a telephone questionnaire lasting approximately 15 minutes, with participants from Lyon who took part in ENDOC TC study, designed to determine the growth of these patients and the presence or absence of symptoms that may be related to post-traumatic damage to the hypothalamic-pituitary system linked to head trauma.",[62,63,64,65],"Craniocerebral Trauma","Hypothalamic-pituitary Disorders","Pediatric","Endocrinology",[67,68,69,70,71],"Traumatic brain injury","Anterior pituitary deficits","Growth delaus","Pituitary or hypothalamic hormone deficiency","Initial Endoc TC study (Ref. Clinical Trials : NCT01250132)","NOT_YET_RECRUITING","2026-05-20",{"date":75,"type":76},"2026-05-22","ACTUAL",{"date":78,"type":58},"2026-04-22",{"date":80,"type":58},"2026-09-30",{"name":5,"class":6},1]