[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639789":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":57,"collaborators":59,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":18,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Vastra Gotaland Region","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Individualized Lifestyle Program","EXPERIMENTAL","The intervention group will receive (offered) an optimal prescription of physical activity and diet based on medical (comorbidities, risk profile, medications, symptoms) and psycho-social (preferences for physical activities and diet, barriers-facilitators, social support, readiness to change, accelerometry and predicted VO2-max data (Ekblom Bak ergometer test), resting energy expenditure and knowledge and skills (lifestyle education school for achieving knowledge and skills in handling change in diet and physical activity in daily life) and support (health promotors, behavioral change app, food diary app, face-to-face, phone\u002Fonline coaching, physical activity (aerobic training, strength training) in group and nudging.",[13],"Behavioral: Individualized physical activity and diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","NO_INTERVENTION","The control group will receive (be offered) usual care defined as written lifestyle advices based on the general recommendations for diet (Nordic Nutrition Recommendations, 2012. Integrating nutrition and physical activity. Copenhagen: Nordic Council of Ministers, 2014) and PA (World Health Organization. World Health Organization guidelines on physical activity and sedentary behavior, 2020), including a healthy and varied diet, aiming at 300 mins\u002Fweek of medium intensity aerobic PA and strength training two times per week.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Individualized physical activity and diet","Precision health",[9],[26],{"name":27,"affiliation":28,"role":29},"Mats Börjesson, Professor","University of Gothenburg, Sahlgrenska University Hospital","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","+46 0705298360","mats.borjesson@gu.se",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Carina U Persson, Associate Professor","+46 706 14 25 60","carina.persson@vgregion.se",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Centre for Lifestyle Intervention","RECRUITING","Gothenburg","Västra Götaland County","416 85","Sweden","SE",{"type":49,"coordinates":50},"Point",[51,52],11.96679,57.70716,{"lat":52,"lon":51},[55],{"name":56,"role":32,"phone":37,"phoneExt":18,"email":38},"Carina U Persson, study coordinator, research leader, Associate Professor",{"type":58,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[60,63],{"name":61,"class":62},"Göteborg University","OTHER",{"name":64,"class":62},"Chalmers University of Technology","100639789","long-term-health-and-economic-effects-of-an-individualized-lifestyle-intervention-li-pad-extended-100639789",false,"NCT07605169","Long-term Health and Economic Effects of an Individualized Lifestyle Intervention (LI-PAD-Extended)","Long-term Follow-up of Individualized Lifestyle Intervention Focused on Physical Activity and Diet: Effects on Weight Loss, Dietary Habits, Cardiovascular Health, Motivation, Health-related Quality of Life, and Health Economics (LI-PAD-Extended)","LI-PAD-EXTENDE","Inclusion Criteria:\n\n* Adults aged 45-65 years at baseline of the original LI-PAD study\n* Body mass index (BMI) ≥28 and ≤34\n* Completed the original LI-PAD study\n* Able and willing to attend follow-up assessments and provide necessary data\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Known coronary artery disease (clinical symptoms or earlier event)\n* Inability to understand the language used in the study\n* Inability to complete follow-up assessments at 18 months\n* Severe illness or medical condition that, in the investigator's opinion, precludes participation in follow-up assessments","ALL","45 Years","65 Years",{"count":77,"type":78},103,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this clinical trial is to learn if an individualized lifestyle intervention works to improve weight, diet, physical activity, cardiovascular health, health-related quality of life, and cost-effectiveness in overweight and obese adults aged 45-65 years.\n\nThe main questions it aims to answer are:\n\nDoes the intervention lead to sustained weight loss after 18 months?\n\nDoes the intervention improve cardiovascular risk factors, metabolic markers, and health-related quality of life compared to general written advice?\n\nIs the intervention cost-effective?\n\nResearchers will compare the individualized lifestyle intervention to a control group that receives general written advice on physical activity and diet to see if the intervention provides greater long-term health and economic benefits.\n\nParticipants will:\n\nAttend counseling sessions with a health promoter Take part in supervised aerobic and resistance training with a physiotherapist Use swimming facilities and participate in the Lifestyle School Access a digital health coach and the online Lifestyle Tool Complete measurements of body weight, diet, physical activity, and cardiovascular health markers (waist-to-hip ratio, blood pressure, blood lipids, fasting glucose, HbA1c, CRP, and liver enzymes) Complete assessments of resting energy expenditure, aerobic fitness, muscle strength, motivation, and health-related quality of life Provide blood samples at baseline, 6 months, and 18 months for dietary biomarker analysis Contribute data for health economic evaluation to assess cost-effectiveness",[84,85,86],"Overweight","Obesity","Prediabetic State",[88,89,90,23,84,85,91,92,93,94,95],"Lifestyle intervention","Physical activity","Diet","Weight loss","Cardiometabolic risk","Health-related quality of life","Behavioral support","Cost-effectiveness","2026-05-19",{"date":98,"type":99},"2026-05-22","ACTUAL",{"date":101,"type":99},"2025-08-11",{"date":103,"type":78},"2027-12-31",{"name":5,"class":6},1]