[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605108":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":30,"responsibleParty":46,"collaborators":48,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Anti-NMDAR encephalitis patients",null,"Patients over 18 years old with NMDAR encephalitis.",[13],"Other: Questionnaires",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Questionnaires","Complete quality of life questionnaires focusing on fatigue, anxiety, depression, and sleep.",[9],[20,26],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Jérôme HONNORAT, Pr","CONTACT","0472357806","+33","jerome.honnorat@chu-lyon.fr",{"name":27,"role":22,"phone":28,"phoneExt":24,"email":29},"Chloé BUTTARD","0426739377","ext-chloe.buttard@chu-lyon.fr",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Centre de référence des syndromes neurologies paranéoplasiques et encéphalites auto-immunes - Hôpital neurologiques Pierre WERTHEIMER - Groupement hospitalier Est - Hospices civiles de Lyon","RECRUITING","Bron","69500","France","FR",{"type":39,"coordinates":40},"Point",[41,42],4.91303,45.73865,{"lat":42,"lon":41},[45],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[49],{"name":50,"class":6},"Charite University, Berlin, Germany","100605108","long-term-impact-of-nmdar-encephalitis-level-3-100605108",false,"NCT07158229","Long-term Impact of NMDAR Encephalitis, Level 3","Social and Psychological Long-term Impact of NMDA Receptor Encephalitis, Level 3","SAPIENCE 3","Inclusion Criteria:\n\n* Patients with NMDAR encephalitis\n* Age ≥ 18 years old\n* Patient affiliated to a social security system\n* No opposition from the patient\n* Access to an internet connection and a computer\n\nExclusion Criteria:\n\n* Patients whithout NMDAR encephalitis\n* Patient under guardianship or curatorship\n* Patient with neurological disorders pre-existing encephalitis","ALL","18 Years",{"count":62,"type":63},30,"ESTIMATED","OBSERVATIONAL","NMDA receptor antibody encephalitis is a rare autoimmune neurological disease of the central nervous system with an estimated incidence of 1.5 people per million per year. Patients with anti-NMDAR encephalitis experience an acute phase of the disease characterized by psychosis, memory loss, seizures, autonomic nervous system instability, or coma. Since the discovery of this disease 14 years ago by Prof. Dalmau, the clinical presentation of the acute phase has been well characterized, while the psychosocial impact of the disease remains largely unexplored.\n\nCurrently, there are few cohort studies of patients that have identified persistent cognitive impairment as a factor impacting remission after the acute phase. Given the scarcity of information concerning the post-acute phase, it is therefore essential to determine the long-term social and psychological outcomes and their daily effects on the social and functional life of this severe disease. This is especially important as the patients are young, with a median age of 21 years, and may face lasting limitations potentially detrimental to their success in professional, educational, or social environments.",[67],"NMDAR Autoimmune Encephalitis",[69,70],"NMDAR encephalitis","psychosocial impact","2026-02-12",{"date":73,"type":74},"2026-02-17","ACTUAL",{"date":76,"type":74},"2025-11-21",{"date":78,"type":63},"2026-11-21",{"name":5,"class":6},1]