[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612539":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":17,"centralContacts":23,"locations":33,"responsibleParty":46,"collaborators":17,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":17,"enrollmentInfo":59,"targetDuration":17,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":72,"whyStopped":17,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"intra dialytic parenteral nutrition (Olimel N12, Baxter, 1L\u002Fsession)","EXPERIMENTAL",[12],"Dietary Supplement: intra dialytic parenteral nutrition (Olimel N12, Baxter, 1L\u002Fsession)",{"label":14,"type":15,"description":16,"interventionNames":17},"Control","NO_INTERVENTION","no intervention according to usual care",null,[19],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":17},"DIETARY_SUPPLEMENT","Olimel N12 is administered via the arteriovenous fistula. Olimel N12 is registered for parenteral use in day-care settings. The dose is 1000 mL (250 mL\u002Fh) per hemodialysis session.",[9],[24,29],{"name":25,"role":26,"phone":27,"phoneExt":17,"email":28},"Wesley J Visser, PhD","CONTACT","+31614285361","w.j.visser@erasmusmc.nl",{"name":30,"role":26,"phone":31,"phoneExt":32,"email":17},"Manon de Geus, MSc","+31650032488","+31651688204",[34],{"facility":35,"status":17,"city":36,"state":17,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":17},"Erasmus MC","Rotterdam","3015GD","Netherlands","NL",{"type":41,"coordinates":42},"Point",[43,44],4.47917,51.9225,{"lat":44,"lon":43},{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Dr. Wesley Visser","Principal investigator, PhD, RD","100612539","long-term-muscle-synthetic-effects-of-intradialytic-parenteral-nutrition-in-chronic-hemodialysis-patients-100612539",false,"NCT07254897","Long-term Muscle Synthetic Effects of Intradialytic Parenteral Nutrition in Chronic Hemodialysis Patients","LOTUS","Inclusion Criteria:\n\n* Age above 18 years\n* Receiving HD treatment over 3 months\n* Receiving HD treatment 3 times per week for at least 4 hours per session\n* 24-hour urine production \\\u003C 100 mL\n* Adequate dialysis dose (eKt\u002FV over 1.2)\n* AV fistula with blood flow (measured invasively or by Doppler ultrasound) over 750 mL\u002Fmin\n\nExclusion Criteria:\n\n* Occurrence of intradialytic hypotension in the last month, defined by systolic blood pressure \\\u003C 90 mm Hg combined with a nursing intervention\n* Hospitalization \\\u003C 3 months before inclusion\n* Active infection or inflammation at randomization\n* Use of oral or intravenous corticosteroids\n* Incapacitation\n* Patients who are not expected to be able to complete the study protocol (e.g., due to a planned kidney transplantation within the planned study time frame)\n* Pregnancy\n* Use of oral anticoagulants or antiplatelet agents that cannot be safely stopped during the study\n* Diabetes mellitus\n* AV fistula with recirculation","ALL","18 Years",{"count":60,"type":61},16,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study examines the effects of intradialytic parenteral nutrition (IDPN) on muscle growth and blood pressure in patients undergoing chronic hemodialysis.",[67],"Malnutrition or Risk of Malnutrition",[69,70,71],"hemodialysis","myofibrillar fractional synthetic rate","intradialytic parenteral nutrition","NOT_YET_RECRUITING","2025-11-20",{"date":75,"type":76},"2025-11-28","ACTUAL",{"date":78,"type":61},"2026-01-01",{"date":80,"type":61},"2027-09-01",{"name":5,"class":6},1]