[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636722":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":39,"collaborators":41,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Umeå University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Antibiotic treatment",null,"Participants having received antibiotic-only treatment for previous Clostridioides difficile infection.",{"label":13,"type":10,"description":14,"interventionNames":10},"Fecal microbiota transplantation (FMT)","Participants having received FMT for previous Clostridioides difficile infection.",[16],{"name":17,"affiliation":18,"role":19},"Johan Rasmuson, MD, PhD","Umeå University, Department of Clinical Microbiology","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","0046-907850000","johan.rasmuson@umu.se",[26],{"facility":27,"status":10,"city":28,"state":10,"zip":10,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Umeå University Hospital","Umeå","Sweden","SE",{"type":32,"coordinates":33},"Point",[34,35],20.25972,63.82842,{"lat":35,"lon":34},[38],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[42],{"name":43,"class":44},"Region Västerbotten","OTHER_GOV","100636722","long-term-outcomes-after-cdi-fmt-versus-antibiotic-only-treatment-100636722",false,"NCT07569380","Long-Term Outcomes After CDI: FMT Versus Antibiotic-Only Treatment","Long-Term Outcomes After Clostridioides Difficile Infection (CDI): Comparative Follow-Up of FMT Versus Antibiotic-Only Treatments (LTO-CDI Cohort)","LTO-CDI","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Symptomatic, microbiologically verified index CDI from February 1 2016 to December 31 2024\n* Having received CDI treatment at Umeå University Hospital (antibiotic-only or FMT)\n\nExclusion Criteria:\n\n* Age below 18 years at follow-up\n* Index CDI diagnosis not meeting ESCMID case definition\n* Testing positive for another gastrointestinal pathogen (virus\u002Fbacteria) that is more plausible to explain the clinical picture at index CDI episode\n* Declines participation","ALL","18 Years",{"count":56,"type":57},250,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about the long-term effects of fecal microbiota transplantation (FMT) compared with antibiotic-only treatment in adults who were treated for Clostridioides difficile infection (CDI) at Umeå University Hospital between 2016 and 2024. The main questions it aims to answer are:\n\n* Do patients treated with FMT maintain higher gut bacterial diversity up to 10 years after CDI compared with patients treated with antibiotics only?\n* Do donor gut bacteria introduced by FMT persist long-term in the recipient's gut?\n* Are there differences in gut metabolism, gut barrier function, and systemic inflammation between FMT-treated and antibiotic-only treated patients at long-term follow-up?\n* What are the long-term safety outcomes - including new diseases, hospitalizations, and mortality - in FMT-treated versus antibiotic-only treated patients?\n\nResearchers will compare patients who received FMT to patients who received antibiotics only to see if FMT leads to lasting differences in gut microbiota, metabolism, immune markers, and clinical outcomes.\n\nParticipants will:\n\n* Attend a single study visit at Umeå University Hospital\n* Provide samples of blood, stool, urine, and a nasal swab\n* Complete two quality-of-life questionnaires\n\nClinical data will be collected from medical records for all participants.",[61],"Clostridioides Difficile Infection",[63,64,65,66,67,9,68],"Clostridioides difficile infection","Fecal microbiota transplantation","Gut microbiota","Microbiome engraftment","Intestinal barrier","Observational study","NOT_YET_RECRUITING","2026-04-28",{"date":72,"type":73},"2026-05-06","ACTUAL",{"date":75,"type":57},"2026-05-01",{"date":77,"type":57},"2031-05-01",{"name":5,"class":6},1]