[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631222":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":36,"collaborators":40,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":96,"sex":102,"minAge":103,"maxAge":10,"enrollmentInfo":104,"targetDuration":107,"studyType":108,"phases":10,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":20,"whyStopped":10,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Jeju National University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Korean CADASIL Cohort",null,"Genetically confirmed NOTCH3 mutation carriers followed prospectively for 10 years with regular clinical evaluations, neuroimaging, neuropsychological assessments, and laboratory testing. No investigational interventions administered.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Jay Chol Professor Choi, MD, PhD, MD, PhD","CONTACT","+82-64-754-8160","jaychoi@jejunu.ac.kr",[19],{"facility":5,"status":20,"city":21,"state":22,"zip":23,"country":24,"countryCode":10,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"RECRUITING","Jeju City","Jeju-do","63241","South Korea",{"type":26,"coordinates":27},"Point",[28,29],126.52194,33.50972,{"lat":29,"lon":28},[32],{"name":33,"role":15,"phone":34,"phoneExt":10,"email":35},"JI HYE Oh, RN, PhD, RN, PhD","+82-64-717-2153","sophia7240@gmail.com",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jay Chol Choi","Professor, MD, PhD, Department of Neurology",[41,43,45,47,49,52,54,56,58,60,62,64,66,68,70,72,74,76,78,80,82,84,86,88,90,92],{"name":42,"class":6},"Asan Medical Center",{"name":44,"class":6},"Chonnam National University Hospital",{"name":46,"class":6},"Chungbuk National University Hospital",{"name":48,"class":6},"Dong-A University Hospital",{"name":50,"class":51},"Ewha Woman University Medical Center","UNKNOWN",{"name":53,"class":6},"Hallym University Medical Center",{"name":55,"class":6},"Hanyang University Seoul Hospital",{"name":57,"class":6},"Inje University Ilsan Paik Hospital",{"name":59,"class":6},"Kangdong Sacred Heart Hospital",{"name":61,"class":6},"Keimyung University Dongsan Medical Center",{"name":63,"class":6},"Korea University Ansan Hospital",{"name":65,"class":6},"Korea University Guro Hospital",{"name":67,"class":6},"Kyung Hee University Hospital",{"name":69,"class":6},"Kyungpook National University Hospital",{"name":71,"class":6},"Nowon Eulji Medical Center",{"name":73,"class":6},"Pusan National University Hospital",{"name":75,"class":6},"Seoul Medical Center",{"name":77,"class":6},"Seoul National University Bundang Hospital",{"name":79,"class":6},"Seoul National University Hospital",{"name":81,"class":6},"Severance Hospital",{"name":83,"class":6},"Soonchunhyang University Hospital",{"name":85,"class":6},"Ulsan University Hospital",{"name":87,"class":6},"Yeungnam University Hospital",{"name":89,"class":6},"Daejeon Eulji University Medical Center",{"name":91,"class":51},"Jeonbuk National University Hospital",{"name":93,"class":6},"DongGuk University","100631222","long-term-prospective-study-of-korean-cadasil-patients-100631222",false,"NCT07497867","Long-term Prospective Study of Korean CADASIL Patients","Long-term Prognosis of Korean Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy(CADASIL) Patients: A Multicenter Prospective Study","K-CADASIL","Inclusion Criteria:\n\n* Age ≥ 19 years\n* CADASIL suspected or confirmed by genetic testing (NOTCH3 mutation)\n* Able to provide written informed consent (participant or legally authorized representative)\n\nExclusion Criteria:\n\n* Contraindication to MRI (claustrophobia, metal implants, pacemaker)\n* Acute ischemic or hemorrhagic stroke within 180 days prior to enrollment","ALL","19 Years",{"count":105,"type":106},500,"ESTIMATED","10 Years","OBSERVATIONAL","K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia. The investigators will track symptoms, brain scans, memory tests, and gene information to understand disease progression in Koreans and identify better treatments. Participants will visit clinics regularly for check-ups and blood tests. This study aims to help improve care for CADASIL patients and families worldwide.",[111,112],"CADASIL","Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy",[111,114,115,116,117,118],"NOTCH3","Stroke","Cerebral Small Vessel Disease","Prospective Study","Korea","2026-05-11",{"date":121,"type":122},"2026-05-14","ACTUAL",{"date":124,"type":122},"2023-07-10",{"date":126,"type":106},"2040-12-31",{"name":5,"class":6},1]