[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100422298":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":35,"locations":41,"responsibleParty":59,"collaborators":22,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":22,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":22,"overallStatus":44,"whyStopped":22,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Henan Institute of Cardiovascular Epidemiology","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group 1","EXPERIMENTAL","Routine treatment + interventions:The patient underwent one RIPC (Four five-minute cycles of upper limb ischaemia and Four five-minute pauses using a blood pressure cuff air vehicle to 200 mmHg) before surgery, then normal surgery, and RIPC was performed on the second day and Once RIPC\u002Fday after CABG for one year.",[13],"Other: remote ischemic preconditioning （RIPC）",{"label":15,"type":10,"description":16,"interventionNames":17},"Experimental Group 2","Routine treatment + interventions:Patients underwent a RIPC before surgery, and then normal medical procedures were performed with no additional intervention.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Control group","NO_INTERVENTION","routine treatment, no RIPC",null,[24],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":22},"remote ischemic preconditioning （RIPC）","Four five-minute cycles of upper limb ischaemia and Four five-minute pauses using a blood pressure cuff inflated to 200 mmHg.",[9,15],[29,33],{"name":30,"affiliation":31,"role":32},"Muwei Li, Ph.D","Fuwai central China cardiovascular hospotial","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":31,"role":32},"Zhaoyun Cheng, Ph.D",[36],{"name":37,"role":38,"phone":39,"phoneExt":22,"email":40},"Quan Guo, MD","CONTACT","+8615670510031","xinyiguoquan@163.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":22,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Fuwai central China cardiovascular Hospital","RECRUITING","Zhengzhou","Henan","China","CN",{"type":50,"coordinates":51},"Point",[52,53],113.64861,34.75778,{"lat":53,"lon":52},[56,57],{"name":37,"role":38,"phone":22,"phoneExt":22,"email":40},{"name":58,"role":32,"phone":22,"phoneExt":22,"email":22},"Muwei Life, MD",{"type":60,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100422298","long-term-remote-ischemic-preconditioning-improves-myocardial-perfusion-and-prognosis-of-patients-after-cabg-100422298",false,"NCT04779008","Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG","Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After Coronary Artery Bypass Grafting","L-RIPC-CABG","Inclusion Criteria:\n\n* Three coronary artery lesions, CABG surgery was planned\n\nExclusion Criteria:\n\n* The patients could not tolerate ripc;\n* peripheral vascular disease affecting upper limbs\n* Acute myocardial infarction complicated with cardiogenic shock，in recent 30 days,\n* Emergency cases\n* Severe structural heart disease and severe arrhythmia ；\n* The uncontrolled systolic blood pressure and diastolic blood pressure of severe hypertension were 180 mmHg and 120 mmHg respectively;\n* Severe liver, renal and pulmonary disease\n* Mental disorder can't cooperate;\n* Inability to give informed consent；\n* Patients on glibenclamide or nicorandil, as these medications may interfere with RIC\n* pregnant;","ALL","18 Years","80 Years",{"count":73,"type":74},210,"ESTIMATED","INTERVENTIONAL",[77],"NA","Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials demonstrated a perioperative cardioprotective effect of RIPC (reduced troponin levels), but did not find that a single preoperative RIPC improved long-term outcomes of coronary artery bypass grafting(CABG).The effect of a single RIPC before CABG may be too short. This study aims to investigate whether long-term RIPC improved myocardial perfusion in patients 3 months and 6 months after CABG surgery , and to detect changes in blood vascular endothelial growth factor, Nitrc Oxide, adenosine，and Endothelin-1, and to observe MACCE event rates at 12 months.",[80],"Coronary Disease","2025-09-12",{"date":83,"type":84},"2025-09-18","ACTUAL",{"date":86,"type":84},"2021-03-10",{"date":88,"type":74},"2026-12-01",{"name":5,"class":6},1]