[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530987":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":30,"locations":36,"responsibleParty":171,"collaborators":10,"id":173,"slug":174,"hasResults":175,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":175,"sex":180,"minAge":10,"maxAge":10,"enrollmentInfo":181,"targetDuration":184,"studyType":185,"phases":10,"briefSummary":186,"conditions":187,"keywords":190,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":203},{"fullName":5,"class":6},"Mirum Pharmaceuticals, Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Alagille syndrome (ALGS)",null,"* A clinically and\u002For genetically confirmed ALGS diagnosis\n* Participant prescribed Livmarli",[13],"Drug: Livmarli",{"label":15,"type":10,"description":16,"interventionNames":17},"Progressive familial intrahepatic cholestasis (PFIC)","* A clinically and\u002For genetically confirmed PFIC diagnosis\n* Prescribed Livmarli",[13],[19,26],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Livmarli","The recommended dosage is 380 mcg\u002Fkg once daily.",[9],[25],"Maralixibat",{"type":20,"name":21,"description":27,"armGroupLabels":28,"otherNames":29},"The recommended dosage us 570 mcg\u002Fkg twice daily.",[15],[25],[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Clinical Trials Mirum","CONTACT","+16506674085","Clinical Trials \u003Cclinicaltrials@mirumpharma.com>;",[37,60,75,92,107,122,139,156],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Children's Hospital Los Angeles CHLA","RECRUITING","Los Angeles","California","90027","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-118.24368,34.05223,{"lat":49,"lon":48},[52,55,57],{"name":53,"role":33,"phone":10,"phoneExt":10,"email":54},"Chuan-Hao Lin, MD","ChLin@chla.usc.edu",{"name":56,"role":33,"phone":10,"phoneExt":10,"email":10},"George Yanni",{"name":58,"role":59,"phone":10,"phoneExt":10,"email":10},"Chuan-Hao Lin","PRINCIPAL_INVESTIGATOR",{"facility":61,"status":39,"city":62,"state":63,"zip":64,"country":43,"countryCode":44,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics and the Digestive Health Institute, Children's Hospital of Colorado and University of Colorado","Aurora","Colorado","80045",{"type":46,"coordinates":66},[67,68],-104.83192,39.72943,{"lat":68,"lon":67},[71,74],{"name":72,"role":33,"phone":10,"phoneExt":10,"email":73},"Shikha S. Sundaram","Shikha.Sundaram@childrenscolorado.org",{"name":72,"role":59,"phone":10,"phoneExt":10,"email":10},{"facility":76,"status":39,"city":77,"state":78,"zip":79,"country":43,"countryCode":44,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Children's Healthcare of Atlanta - Emory University School of Medicine","Atlanta","Georgia","30322",{"type":46,"coordinates":81},[82,83],-84.38798,33.749,{"lat":83,"lon":82},[86,90],{"name":87,"role":33,"phone":88,"phoneExt":10,"email":89},"Angela Stallworth","404-785-3279","Angela.Stallworth@choa.org",{"name":91,"role":59,"phone":10,"phoneExt":10,"email":10},"Chrissy Lopez",{"facility":93,"status":39,"city":94,"state":95,"zip":96,"country":43,"countryCode":44,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Children's Mercy Kansas City, Department of Gastroenterology, Section of Hepatology","Kansas City","Missouri","64108",{"type":46,"coordinates":98},[99,100],-94.57857,39.09973,{"lat":100,"lon":99},[103,106],{"name":104,"role":33,"phone":10,"phoneExt":10,"email":105},"Ryan T. Fischer","rtfischer@cmh.edu",{"name":104,"role":59,"phone":10,"phoneExt":10,"email":10},{"facility":108,"status":39,"city":109,"state":110,"zip":111,"country":43,"countryCode":44,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Oregon Health and Science University, Division of Pediatric Gastroenterology, Department of Pediatrics","Portland","Oregon","97239",{"type":46,"coordinates":113},[114,115],-122.67621,45.52345,{"lat":115,"lon":114},[118,121],{"name":119,"role":33,"phone":10,"phoneExt":10,"email":120},"Henry C. Lin","linhe@ohsu.edu",{"name":119,"role":59,"phone":10,"phoneExt":10,"email":10},{"facility":123,"status":39,"city":124,"state":125,"zip":126,"country":43,"countryCode":44,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":46,"coordinates":128},[129,130],-75.16362,39.95238,{"lat":130,"lon":129},[133,137],{"name":134,"role":33,"phone":135,"phoneExt":10,"email":136},"Kathleen Loomes","267-426-7223","LOOMES@email.chop.edu",{"name":138,"role":59,"phone":10,"phoneExt":10,"email":10},"Kathleen Loomes, MD",{"facility":140,"status":39,"city":141,"state":125,"zip":142,"country":43,"countryCode":44,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Children Hospital of Pittsburgh","Pittsburgh","15260",{"type":46,"coordinates":144},[145,146],-79.99589,40.44062,{"lat":146,"lon":145},[149,152,154],{"name":150,"role":33,"phone":10,"phoneExt":10,"email":151},"Simon Horslen, MD","horslensp@upmc.edu",{"name":153,"role":33,"phone":10,"phoneExt":10,"email":10},"James E. Squires",{"name":155,"role":59,"phone":10,"phoneExt":10,"email":10},"Simon Horslen",{"facility":157,"status":39,"city":158,"state":159,"zip":160,"country":43,"countryCode":44,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"University of Utah, Division of Pediatric Gastroenterology, Hepatology and Nutrition","Salt Lake City","Utah","84112",{"type":46,"coordinates":162},[163,164],-111.89105,40.76078,{"lat":164,"lon":163},[167,170],{"name":168,"role":33,"phone":10,"phoneExt":10,"email":169},"M. Kyle Jensen","kyle.jensen@hsc.utah.edu",{"name":168,"role":59,"phone":10,"phoneExt":10,"email":10},{"type":172,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100530987","long-term-safety-and-clinical-outcomes-of-livmarli-in-patients-in-the-united-states-leap-us-100530987",false,"NCT06193928","Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)","LEAP","Inclusion Criteria:\n\n* A clinically and\u002For genetically confirmed ALGS diagnosis or PFIC diagnosis\n* Participant prescribed Livmarli\n\nExclusion Criteria:\n\n* Refusal to provide informed consent\u002Fassent (if required by the local IRB)\n* Previously or currently on Livmarli through participation in a clinical study or expanded access program\n* Participants who have previously received an SBD or LT\n* Any condition or abnormalities that, in the opinion of the investigator, may interfere with the participant participating in or completing the study\n* Participants who have received an investigational drug within 30 days of the first dose of Livmarli","ALL",{"count":182,"type":183},70,"ESTIMATED","5 Years","OBSERVATIONAL","The objective of this 5-year, prospective, observational cohort study is to evaluate the long-term safety and clinical outcomes of patients with Alagille syndrome (ALGS) or Progressive familial intrahepatic cholestasis (PFIC) treated with Livmarli.",[188,189],"Alagille Syndrome","Progressive Familial Intrahepatic Cholestasis",[191,192,193,21,188,189],"ALGS","Liver Diseases","PFIC","2025-05-21",{"date":196,"type":197},"2025-05-25","ACTUAL",{"date":199,"type":197},"2023-09-21",{"date":201,"type":183},"2030-09-20",{"name":5,"class":6},8]