[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100352417":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":20,"locations":25,"responsibleParty":46,"collaborators":20,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":20,"eligibilityCriteria":54,"healthyVolunteers":51,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":20,"overallStatus":27,"whyStopped":20,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Gastric sleeve surgery","EXPERIMENTAL","before and after weight loss from bariatric surgery",[13],"Procedure: Gastric sleeve\u002Fbariatric surgery",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Gastric sleeve\u002Fbariatric surgery","weight loss",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Michael D Jensen, MD","PRINCIPAL_INVESTIGATOR",[26],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Rochester","Minnesota","559055","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-92.4699,44.02163,{"lat":37,"lon":36},[40,45],{"name":41,"role":42,"phone":43,"phoneExt":20,"email":44},"Reich Pamela","CONTACT","5072556062","reich.pamela@mayo.edu",{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Michael D. Jensen","Principal Investigator","100352417","long-term-substantial-weight-loss-and-insulin-regulation-of-lipolysis-100352417",false,"NCT03868592","Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis","Inclusion Criteria:\n\n* BMI 40 - 50 kg\u002Fm2.\n* Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery\n\nExclusion Criteria:\n\n* Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg\u002FdL\n* Active coronary artery disease\n* Participation in structured exercise (\\>2 times per week for 30 minutes or longer)\n* Smoking\n* Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)\n* Renal insufficiency (serum creatinine \\> 1.5mg\u002Fdl)\n* Chronic active liver disease (Bilirubin \\> 17mmol\u002FL, AST \\> 144 IU\u002FL, or ALT\\>165IU\u002FL)\n* Pregnancy or breastfeeding.","ALL","18 Years","65 Years",{"count":59,"type":60},30,"ESTIMATED","INTERVENTIONAL",[63],"NA","It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.",[66],"Obesity, Morbid","2026-02-27",{"date":69,"type":70},"2026-03-03","ACTUAL",{"date":72,"type":70},"2019-08-01",{"date":74,"type":60},"2027-05",{"name":5,"class":6},1]