[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544836":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":35,"collaborators":39,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Leiden University Medical Center","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cases - Enriched for familial longevity",null,"Siblings of dutch Caucasian descent ages 75 and older",{"label":13,"type":10,"description":14,"interventionNames":10},"Controls - Non-enriched for familial longevity","Individuals of dutch Caucasian descent ages 75 and older solely in their family.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"(Eline) P. Slagboom, Prof. dr.","CONTACT","+31(0)71 5269 730","p.slagboom@lumc.nl",[22],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":10},"RECRUITING","Leiden","South Holland","2333ZA","Netherlands","NL",{"type":30,"coordinates":31},"Point",[32,33],4.49306,52.15833,{"lat":33,"lon":32},{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Eline Slagboom","Eline Slagboom, Prof. dr.",[40,43],{"name":41,"class":42},"Jacobijn Gussekloo, Prof. dr.","UNKNOWN",{"name":44,"class":42},"Simon P. Mooijaart, Prof. dr.","100544836","longevity-families-of-the-netherlands-100544836",false,"NCT06374069","Longevity Families of the Netherlands","LOF-NL","Inclusion Criteria:\n\n* Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity\n* Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity\n\nExclusion Criteria:\n\n\\-",true,"ALL","75 Years",{"count":56,"type":57},600,"ESTIMATED","OBSERVATIONAL","The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.\n\nThe purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.",[61,62,63,64],"Longevity","Familial Longevity","Extreme Longevity","Aging","2024-04-15",{"date":67,"type":68},"2024-04-18","ACTUAL",{"date":70,"type":68},"2023-09-11",{"date":72,"type":57},"2026-12",{"name":5,"class":6},1]