[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609121":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":11,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":11,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":11,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Chronic Spinal Cord Injury","EXPERIMENTAL",null,[13,14,15],"Diagnostic Test: Tests of sympathetic inhibition","Diagnostic Test: Tests of above level sympathetic activation","Diagnostic Test: Testing of below level sympathetic activation",{"label":17,"type":10,"description":11,"interventionNames":18},"Acute Spinal Cord Injury",[13,14,15],[20,25,29],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DIAGNOSTIC_TEST","Tests of sympathetic inhibition","Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.",[17,9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Tests of above level sympathetic activation","Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).",[17,9],{"type":21,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Testing of below level sympathetic activation","Cold pressor test of the foot and bladder pressor response will be tested.",[17,9],[34],{"name":35,"affiliation":5,"role":36},"Ryan J. Solinsky, MD","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},"Erin Lund","CONTACT","507-284-9298","lund.erin@mayo.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-92.4699,44.02163,{"lat":55,"lon":54},[58,59],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},{"name":35,"role":36,"phone":11,"phoneExt":11,"email":11},{"type":36,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Ryan J. Solinsky","Principal Investigator",[64],{"name":65,"class":6},"The Craig H. Neilsen Foundation","100609121","longitudinal-autonomic-characterization-as-a-predictor-for-secondary-medical-complications-post-sci-100609121",false,"NCT07210437","Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI","Inclusion criteria\n\n* 18-75 years old\n* Spinal cord injury with neurological level of injury from C6-T12\n* ASIA Impairment Scale A-D.\n* Either acute SCI \\\u003C3 months prior (n=10) or chronic SCI (\\>1 year since injury, n=8).\n\nExclusion criteria\n\n* Symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment);\n* Women who are pregnant or lactating\n* Taking or being administered a medication known to potentially have adverse interactions with phenylephrine\n* In the judgement of the principal investigator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.","ALL","18 Years","75 Years",{"count":76,"type":77},18,"ESTIMATED","INTERVENTIONAL",[80],"NA","The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.",[83],"Spinal Cord Injuries","2026-05-26",{"date":86,"type":87},"2026-05-28","ACTUAL",{"date":89,"type":87},"2026-01-31",{"date":91,"type":77},"2028-06-01",{"name":5,"class":6},1]