[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636697":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":33,"responsibleParty":51,"collaborators":54,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":10,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":10,"maxAge":10,"enrollmentInfo":86,"targetDuration":10,"studyType":89,"phases":10,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Retrospective cohort",null,"Patients whose first visit to our institution and the termination of follow-up both occurred before the opening of this study will contribute to the retrospective cohort.",{"label":13,"type":10,"description":14,"interventionNames":10},"Prospective cohort","Patients whose first visit to our institution occur after the opening of this study will contribute to the prospective cohort.",{"label":16,"type":10,"description":17,"interventionNames":10},"Retrospective\u002FProspective cohort","Patients whose first visit to our institution occurred before the opening of this study and whose follow-up will terminate after the opening of this study will contribute to the ambispective cohort.",[19],{"name":20,"affiliation":21,"role":22},"Xiao-Hui Zhang, MD","Peking University Institute of Hematology, Peking University People's Hospital","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Jin Wu, MD","CONTACT","086-01088326002","wujin1996@126.com",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"Fanhao Nie","086-18887323790","Niefh2003@163.com",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Beijing","Beijing Municipality","100044","China","CN",{"type":42,"coordinates":43},"Point",[44,45],116.39723,39.9075,{"lat":45,"lon":44},[48],{"name":49,"role":26,"phone":50,"phoneExt":10,"email":28},"Xiaohui Zhang, MD","01088326666",{"type":22,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Xiao Hui Zhang","Vice President of Peking University Institute of Hematology Affiliation: Peking University People's Hospital",[55,57,59,61,63,65,68,70,72,74,76],{"name":56,"class":6},"First Affiliated Hospital of Guangxi Medical University",{"name":58,"class":6},"First Affiliated Hospital of Harbin Medical University",{"name":60,"class":6},"The First Hospital of Jilin University",{"name":62,"class":6},"Jining Medical University",{"name":64,"class":6},"Qianfoshan Hospital",{"name":66,"class":67},"Shandong Provincial Hospital","OTHER_GOV",{"name":69,"class":6},"Shanxi Province Cancer Hospital",{"name":71,"class":6},"Shengjing Hospital",{"name":73,"class":6},"First Affiliated Hospital of Xinjiang Medical University",{"name":75,"class":6},"Zhejiang University",{"name":77,"class":6},"The General Hospital of Northern Theater Command","100636697","longitudinal-cohort-study-on-invasive-fungal-disease-after-allogeneic-hematopoietic-stem-cell-transplantation-100636697",false,"NCT07569055","Longitudinal Cohort Study on Invasive Fungal Disease After Allogeneic Hematopoietic Stem Cell Transplantation","Retrospective and Prospective Longitudinal Observational Study on Invasive Fungal Disease After Allogeneic Hematopoietic Stem Cell Transplantation","Inclusion Criteria:\n\nSince January 1, 2014, patients who underwent allo-HSCT at Peking University People's Hospital and other assistance centers.\n\nExclusion Criteria:\n\n1. For any reason, such as the occurrence of severe mental disorders, the follow-up information may be unavailable;\n2. Patients deemed unsuitable for the study by the researchers.","ALL",{"count":87,"type":88},6000,"ESTIMATED","OBSERVATIONAL","Invasive fungal disease (IFD) is one of the serious complications after hematopoietic stem cell transplantation (HSCT), characterized by high incidence and high mortality. According to the data from a multi-center study in China (CAESAR 2.0), even with the extensive use of antifungal active drugs for prevention, the cumulative incidence of IFD one year after HSCT still reached 6.3%, and the IFD-related mortality rate was 48.28%. In recent years, with the improvement of transplantation techniques, the application of new antifungal drugs and the optimization of diagnostic methods, the pathogen spectrum and clinical characteristics of IFD have undergone significant changes. Compared with ten years ago, the proportion of non-Aspergillus pathogens (such as Candida and Mucophora) has significantly increased, while the proportion of Aspergillus has relatively decreased. In addition, different types of invasive mycosis (such as invasive aspergillosis and invasive fusarium) show significant differences in clinical manifestations, onset time and prognosis. However, at present, large-scale prospective cohort studies on IFD after HSCT in China are still relatively scarce, and the diagnosis and treatment norms and prevention strategies in clinical practice still need to be further optimized. This study intends to conduct a multi-center retrospective and prospective combined longitudinal cohort study to comprehensively register the basic information, diagnosis, treatment and prognosis of IFD patients after HSCT, providing evidence-based medical basis for establishing new clinical diagnosis and treatment technologies and improving the long-term survival rate of patients.",[92,93],"Invasive Fungal Disease","Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)",[95,92,96,97],"Allogeneic Hematopoietic Stem Cell Transplantation","Prediction","Prognosis","2026-05-01",{"date":100,"type":101},"2026-05-06","ACTUAL",{"date":103,"type":101},"2025-03-15",{"date":105,"type":88},"2031-03-14",{"name":5,"class":6},1]