[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100449486":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":35,"responsibleParty":68,"collaborators":71,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":10,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":10,"enrollmentInfo":86,"targetDuration":10,"studyType":89,"phases":10,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control",null,"Patients who have undergone an endoscopy within the last three years and have never been diagnosed with Barrett's esophagus.",[13],"Other: Sample collection",{"label":15,"type":10,"description":16,"interventionNames":17},"Barrett's Esophagus","Patients who have undergone an endoscopy within the last three years and have histologically confirmed Barrett's esophagus. BE segment must be M\\>1cm, and has not be treated with endoscopic eradication therapy (focal mucosal resection without subsequent eradication therapy is allowed).",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Sample collection","Collection of saliva sample",[15,9],[24],{"name":25,"affiliation":5,"role":26},"Julian Abrams, MD","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","212-305-1909","ja660@cumc.columbia.edu",{"name":33,"role":29,"phone":10,"phoneExt":10,"email":34},"Katharine Boyce, RN","kb3217@cumc.columbia.edu",[36,57],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University of Michigan","RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-83.74088,42.27756,{"lat":48,"lon":47},[51,54],{"name":52,"role":29,"phone":10,"phoneExt":10,"email":53},"Joel H. Rubenstein, MD","jhr@med.umich.edu",{"name":55,"role":29,"phone":10,"phoneExt":10,"email":56},"Amy Liu","Liuyalie@med.umich.edu",{"facility":58,"status":38,"city":59,"state":59,"zip":60,"country":42,"countryCode":43,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Columbia University Irving Medical Center","New York","10032",{"type":45,"coordinates":62},[63,64],-74.00597,40.71427,{"lat":64,"lon":63},[67],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},{"type":26,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Julian A Abrams, MD","Associate Professor of Medicine and Epidemiology",[72,73],{"name":37,"class":6},{"name":74,"class":75},"National Cancer Institute (NCI)","NIH","100449486","longitudinal-oral-microbiome-sampling-for-be-100449486",false,"NCT05133102","Longitudinal Oral Microbiome Sampling for BE","Repeated Sampling of the Oral Microbiome to Improve Detection of Barrett's Esophagus","Inclusion Criteria:\n\n* Scheduled for an upper endoscopy or had upper endoscopy within past three years\n* Eighteen years of age or older\n* Capable of producing a saliva sample\n* Able to give informed consent\n* For BE patients only: Endoscopic evidence of Barrett's esophagus (at least 1 cm maximal BE length; i.e. Prague classification: any C, M≥1), and intestinal metaplasia present on esophageal biopsies\n\nExclusion Criteria:\n\n* History of head and neck cancer or esophageal squamous cell or gastric cancer\n* History of esophageal or gastric surgery\n* Scheduled to undergo colonoscopy on the day of initial saliva collection\n* Scheduled only for Endoscopic retrograde cholangiopancreatography (ERCP) or Endoscopy ultrasound (EUS) without accompanying standard upper endoscopy on the day of initial saliva collection\n* For BE patients only: History of prior endoscopic therapy for BE except a history of prior Endoscopic mucosal resection (EMR) of focal lesions without subsequent ablative therapy is permitted",true,"ALL","18 Years",{"count":87,"type":88},275,"ESTIMATED","OBSERVATIONAL","This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.",[92],"Barrett Esophagus",[94,95,96],"Saliva","Sampling","Oral Microbiome","2026-05-08",{"date":99,"type":100},"2026-05-12","ACTUAL",{"date":102,"type":100},"2021-03-19",{"date":104,"type":88},"2027-08",{"name":5,"class":6},2]