[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530733":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":74,"collaborators":77,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":7,"maxAge":7,"enrollmentInfo":89,"targetDuration":7,"studyType":92,"phases":7,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Nancy E Braverman, MD, MS","PRINCIPAL_INVESTIGATOR",[13,18],{"name":10,"role":14,"phone":15,"phoneExt":16,"email":17},"CONTACT","514-934-1934","23404","nancy.braverman@mcgill.ca",{"name":19,"role":14,"phone":15,"phoneExt":16,"email":20},"Frederique Arnaud, BScN","frederique.arnaud@muhc.mcgill.ca",[22,42,61],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"University of Rochester Medical Center\u002FFlaum Eye Institute","RECRUITING","Rochester","New York","14642","United States","US",{"type":31,"coordinates":32},"Point",[33,34],-77.61556,43.15478,{"lat":34,"lon":33},[37,40],{"name":38,"role":14,"phone":7,"phoneExt":7,"email":39},"Alex Levin, MD","alex_levin@urmc.rochester.edu",{"name":41,"role":11,"phone":7,"phoneExt":7,"email":7},"Alex Levin",{"facility":43,"status":24,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Eye Institute of Alberta","Edmonton","Alberta","T5H 3V9","Canada","CA",{"type":31,"coordinates":50},[51,52],-113.46871,53.55014,{"lat":52,"lon":51},[55,59],{"name":56,"role":14,"phone":57,"phoneExt":7,"email":58},"Constantin Mouzaaber, MSc","587-590-5041","muzaber@ualberta.ca",{"name":60,"role":11,"phone":7,"phoneExt":7,"email":7},"Matthew Benson, MD, MSc",{"facility":62,"status":24,"city":63,"state":64,"zip":65,"country":47,"countryCode":48,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Research Institute-McGill University Health Center","Montreal","Quebec","H4A 3J1",{"type":31,"coordinates":67},[68,69],-73.58781,45.50884,{"lat":69,"lon":68},[72,73],{"name":19,"role":14,"phone":7,"phoneExt":7,"email":20},{"name":10,"role":11,"phone":7,"phoneExt":7,"email":7},{"type":11,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Nancy Braverman","Professor",[78],{"name":79,"class":80},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100530733","longitudinal-prospective-natural-history-study-of-retinopathy-in-zellweger-spectrum-disorder-100530733",false,"NCT06190626","Longitudinal Prospective Natural History Study of Retinopathy in Zellweger Spectrum Disorder","ZSDvision","Inclusion Criteria:\n\n* confirmed ZSD with deleterious variants in PEX genes identified\n* confirmed or expected retinal involvement\n\nExclusion Criteria:\n\n* unable to perform a minimum of one vision test\n* severe ZSD disease","ALL",{"count":90,"type":91},30,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to define the course of the retinal degeneration in a ZSD patient cohort.\n\nThe objective of this study is to gather information so the investigators can:\n\n1. define the course of the retinal degeneration in a ZSD patient cohort with retinal degeneration\n2. define what tests best monitor the progression of the retinal degeneration\n3. generate prognostic information about vision loss in ZSD.\n\nAt each yearly visit, the participants will answer a functional vision questionnaire, have a physical evaluation, blood test, and participate in a variety of vision tests. The investigators will also collect pertinent medical history.\n\nParticipants will travel to study site. The study will provide financial support for board and travel.",[95],"Zellweger Spectrum Disorder",[97,98,99],"ZSD","PEX gene mutation","Retinopathy","2026-01-19",{"date":102,"type":103},"2026-01-21","ACTUAL",{"date":105,"type":103},"2023-12-18",{"date":107,"type":91},"2029-01-01",{"name":5,"class":6},3]