[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100355555":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":58,"centralContacts":63,"locations":73,"responsibleParty":90,"collaborators":10,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":10,"eligibilityCriteria":98,"healthyVolunteers":99,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":10,"studyType":106,"phases":10,"briefSummary":107,"conditions":108,"keywords":10,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"Western University, Canada","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cannabis Smoker",null,"Participants in this group will be current or former cannabis smokers",[13,14,15,16,17,18,19],"Diagnostic Test: Hyperpolarized Xenon-129 MRI of the lungs","Diagnostic Test: Computed Tomography (CT)","Diagnostic Test: Pulmonary Function Tests (PFTs)","Diagnostic Test: Six Minute Walk Test (6MWT)","Diagnostic Test: Cardiopulmonary exercise testing (CPET)","Diagnostic Test: Sputum analysis","Diagnostic Test: Blood analysis",[21,26,32,38,44,50,54],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIAGNOSTIC_TEST","Hyperpolarized Xenon-129 MRI of the lungs","Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Computed Tomography (CT)","Participants will undergo a CT scan of the thoracic cavity",[9],[31],"CT",{"type":22,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Pulmonary Function Tests (PFTs)","Participants will have their lung function evaluated using PFTs",[9],[37],"PFTs",{"type":22,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Six Minute Walk Test (6MWT)","Participants \\>35 years of age will perform the six minute walk test as a measure of exercise capacity",[9],[43],"6MWT",{"type":22,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"Cardiopulmonary exercise testing (CPET)","Participants \\\u003C35 will perform cardiopulmonary exercise testing as a measure of exercise capacity",[9],[49],"CPET",{"type":22,"name":51,"description":52,"armGroupLabels":53,"otherNames":10},"Sputum analysis","Participants will provide a sputum sample that will be analysed for eosinophils",[9],{"type":22,"name":55,"description":56,"armGroupLabels":57,"otherNames":10},"Blood analysis","Participants will have their blood drawn and analysed for eosinophil count.",[9],[59],{"name":60,"affiliation":61,"role":62},"Grace E Parraga, PhD","Robarts Research Institute, The University of Western Ontario","PRINCIPAL_INVESTIGATOR",[64,68],{"name":60,"role":65,"phone":66,"phoneExt":10,"email":67},"CONTACT","519-931-5265","gparraga@uwo.ca",{"name":69,"role":65,"phone":70,"phoneExt":71,"email":72},"Angela P Wilson, RRT","519-931-5777","24197","awilson@robarts.ca",[74],{"facility":75,"status":76,"city":77,"state":78,"zip":79,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":88},"Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre","RECRUITING","London","Ontario","N6A 5B7","Canada","CA",{"type":83,"coordinates":84},"Point",[85,86],-81.23304,42.98339,{"lat":86,"lon":85},[89],{"name":60,"role":65,"phone":66,"phoneExt":10,"email":67},{"type":91,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100355555","longitudinal-study-of-xenon-129-mri-imaging-effects-of-cannabis-smoking-100355555",false,"NCT03909477","Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking","Longitudinal Study of Xenon-129 MRI Imaging of Effects of Cannabis Smoking on Lung Structure and Function","Inclusion Criteria:\n\n* Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature\n* Provision of written, informed consent prior to any study specific procedures\n* Males and females aged 18-85\n* Current or former cannabis smoker (medicinal or recreational) with or without concurrent tobacco smoking history\n* Participant is able to perform reproducible pulmonary function testing (i.e. the 3 best acceptable spirograms have Forced Expiratory Volume in 1 second (FEV1) values that do not vary more than 150 millilitres)\n* Participant is able to perform a breathhold for 16s\n* FEV1 \\> 25% predicted\n* Forced Vital Capacity (FVC) \\> 25% predicted and \\>0.5 litres\n\nExclusion Criteria:\n\n* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material\n* Participant is medically unstable in the opinion of the Principal Investigator\n* Participant has a daytime room air oxygen saturation \\\u003C90% while lying supine\n* Participant is unable to perform spirometry or plethysmography maneuvers\n* Patient is pregnant at time of enrolment\n* In the opinion of the investigator, patient suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia\n* Patient has implanted mechanically, electrically or magnetically activated device or any metal in their body, which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and\u002For ear implants) - at the discretion of the MRI Technologist.",true,"ALL","18 Years","85 Years",{"count":104,"type":105},200,"ESTIMATED","OBSERVATIONAL","This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.",[109,110,111,112],"Cannabis Use","Cannabis Smoking","Marijuana Smoking","Marijuana Usage","2025-08-11",{"date":115,"type":116},"2025-08-15","ACTUAL",{"date":118,"type":116},"2022-06-01",{"date":120,"type":105},"2030-12-01",{"name":5,"class":6},1]