[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644945":3},{"organization":4,"armGroups":7,"interventions":42,"overallOfficials":52,"centralContacts":56,"locations":62,"responsibleParty":81,"collaborators":47,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":47,"enrollmentInfo":95,"targetDuration":47,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":47,"overallStatus":64,"whyStopped":47,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Bath","OTHER",[8,14,18,22,26,30,34,38],{"label":9,"type":6,"description":10,"interventionNames":11},"Sequence 1","Participants will follow a 1) low-carbohydrate diet, wash-out, 2) control diet, wash-out, 3) low-carbohydrate diet, wash-out, 4) control diet, wash-out, 5) low-carbohydrate diet, wash-out, 6) control diet",[12,13],"Other: control diet","Other: Low carbohydrate diet",{"label":15,"type":6,"description":16,"interventionNames":17},"Sequence 2","Participants will follow a 1) low-carbohydrate diet, wash-out, 2) control diet, wash-out, 3) low-carbohydrate diet, wash-out, 4) control diet, wash-out, 5) control diet, wash-out, 6) low-carbohydrate diet",[12,13],{"label":19,"type":6,"description":20,"interventionNames":21},"Sequence 3","Participants will follow a 1) low-carbohydrate diet, wash-out, 2) control diet, wash-out, 3) control diet, wash-out, 4) low-carbohydrate diet, wash-out, 5) control diet, wash-out, 6) low-carbohydrate diet",[12,13],{"label":23,"type":6,"description":24,"interventionNames":25},"Sequence 4","Participants will follow a 1) low-carbohydrate diet, wash-out, 2) control diet, wash-out, 3) control diet, wash-out, 4) low-carbohydrate diet, wash-out, 5) low-carbohydrate diet, wash-out, 6) control diet",[12,13],{"label":27,"type":6,"description":28,"interventionNames":29},"Sequence 5","Participants will follow a 1) control diet, wash-out, 2) low-carbohydrate diet, wash-out, 3) control diet, wash-out, 4) low-carbohydrate diet, wash-out, 5) control diet, wash-out, 6) low-carbohydrate diet",[12,13],{"label":31,"type":6,"description":32,"interventionNames":33},"Sequence 6","Participants will follow a 1) control diet, wash-out, 2) low-carbohydrate diet, wash-out, 3) control diet, wash-out, 4) low-carbohydrate diet, wash-out, 5) low-carbohydrate diet, wash-out, 6) control diet",[12,13],{"label":35,"type":6,"description":36,"interventionNames":37},"Sequence 7","Participants will follow a 1) control diet, wash-out, 2) low-carbohydrate diet, wash-out, 3) low-carbohydrate diet, wash-out, 4) control diet, wash-out, 5) control diet, wash-out, 6) low-carbohydrate diet",[12,13],{"label":39,"type":6,"description":40,"interventionNames":41},"Sequence 8","Participants will follow a 1) control diet, wash-out, 2) low-carbohydrate diet, wash-out, 3) low-carbohydrate diet, wash-out, 4) control diet, wash-out, 5) low-carbohydrate diet, wash-out, 6) control diet",[12,13],[43,48],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"control diet","Diet will have macronutrients split with 50% carbohydrates, 15% protein and 35% fat. Also there will be a 0.66 ratio saturated:unsaturated fat",[9,15,19,23,27,31,35,39],null,{"type":6,"name":49,"description":50,"armGroupLabels":51,"otherNames":47},"Low carbohydrate diet","Diet will have macronutrients split with 8% carbohydrates, 15% protein and 77% fat. Also there will be a 0.66 ratio saturated:unsaturated fat",[9,15,19,23,27,31,35,39],[53],{"name":54,"affiliation":5,"role":55},"Javier Gonzalez, PhD","PRINCIPAL_INVESTIGATOR",[57],{"name":58,"role":59,"phone":60,"phoneExt":47,"email":61},"Bruno Spellanzon, PhD candidate","CONTACT","447769407954","bs954@bath.ac.uk",[63],{"facility":5,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"RECRUITING","Bath","Bath and North East Somerset","BA2 7AY","United Kingdom","UK",{"type":71,"coordinates":72},"Point",[73,74],-2.36172,51.3751,{"lat":74,"lon":73},[77,78,80],{"name":58,"role":59,"phone":60,"phoneExt":47,"email":61},{"name":54,"role":59,"phone":47,"phoneExt":47,"email":79},"jg833@bath.ac.uk",{"name":54,"role":55,"phone":47,"phoneExt":47,"email":47},{"type":55,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":47,"oldOrganization":47},"Bruno Spellanzon","Principal Investigator","100644945","low-carbohydrate-diet-and-low-density-lipoprotein---cholesterol-ldl-c-interindividual-variability-100644945",false,"NCT07675603","Low-carbohydrate Diet and Low-Density Lipoprotein - Cholesterol (LDL-c) Interindividual Variability","Exploring True Interindividual Heterogeneity of Cardiovascular Disease (CVD) Risk Factors in Response to Low-carbohydrate Diets Using a Replicate Crossover Randomised Controlled Trial","REPETO","Inclusion Criteria:\n\n* Age: \\>18 years\n* Body mass index: 18.5-35 kg·m-2\n* Low-Density Lipoprotein-cholesterol \\\u003C4.9 mmol\u002FL\n* Non-fasting triglycerides \\\u003C2.3 mmol\u002FL\n\nExclusion Criteria:\n\n* weight instability (\\>5% change in body mass within last 3 months)\n* smoker\n* diagnosis of hypercholesterolaemia or any other lipid-related disease\n* diagnosis of diabetes\n* diagnosis of atherosclerotic cardiovascular disease\n* elevated fasting glucose (\\>5.4 mmol\u002FL)\n* dietary intolerances or allergies or to other study procedures\n* diagnosis of gastrointestinal disorders\n* any other condition\u002Fmedication that could introduce bias to the study\n* already following a ketogenic diet\n* not willing to follow a ketogenic diet\n* unable to understand English language",true,"ALL","18 Years",{"count":96,"type":97},20,"ESTIMATED","INTERVENTIONAL",[100],"NA","Ketogenic diets are very low-carbohydrate diets that increase hepatic production of ketone bodies, which have several effects as substrates and signals. Ketogenic diets are used to manage some conditions (e.g., drug-resistant epilepsy), and their potential for managing many other conditions (e.g., cancer) is being actively explored. Indeed, the British Dietetic Association acknowledge the potential for ketogenic diets to improve glycaemic control to a greater extent than some other diets in people with type 2 diabetes. A lower fasting glucose is also relevant to future mortality in people without diabetes. Ketogenic diets are popular in the general population, with up to 15% of the UK following a low-carbohydrate diet. There is, therefore, great interest in ketogenic diets amongst people with and without health conditions. However, although the diet shows promising results in improving blood sugar levels, it has also shown to increase low-density lipoprotein-cholesterol (LDL-c) in some individuals, which has been linked to increased cardiovascular health risks. The aim of this project is to find the potential for personalised use of (or guidance to avoid) ketogenic diets for cardiovascular disease risk. To do that the investigators will ask participants to replicate 24 hours of a ketogenic diet and a control diet thrice each. This will allow the investigators to find variability between responses and have a better idea of individuals who could benefit (or not) from following the ketogenic diet.",[103],"Healthy","2026-06-25",{"date":106,"type":107},"2026-06-30","ACTUAL",{"date":109,"type":107},"2026-02-05",{"date":111,"type":97},"2027-03",{"name":5,"class":6},1]