[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100351619":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":42,"centralContacts":46,"locations":52,"responsibleParty":200,"collaborators":202,"id":206,"slug":207,"hasResults":208,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":26,"eligibilityCriteria":212,"healthyVolunteers":208,"sex":213,"minAge":214,"maxAge":26,"enrollmentInfo":215,"targetDuration":26,"studyType":218,"phases":219,"briefSummary":221,"conditions":222,"keywords":26,"overallStatus":55,"whyStopped":26,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":235},{"fullName":5,"class":6},"University of Southern California","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment (low-dose radiation therapy)","EXPERIMENTAL","Patients receive low-dose radiation therapy at consecutive business days 1 and 2 in the absence of disease progression or unacceptable toxicity. Patients with no pain relief may receive additional radiotherapy at 4 weeks following initial radiotherapy.",[13,14,15],"Other: Quality-of-Life Assessment","Other: Questionnaire Administration","Radiation: Radiation Therapy",[17,23,27],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"Quality-of-Life Assessment","Ancillary studies",[9],[22],"Quality of Life Assessment",{"type":6,"name":24,"description":19,"armGroupLabels":25,"otherNames":26},"Questionnaire Administration",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"RADIATION","Radiation Therapy","Receive low-dose radiation therapy",[9],[33,34,35,36,37,38,39,40,41],"Cancer Radiotherapy","Irradiate","Irradiated","irradiation","Radiation","Radiotherapeutics","RADIOTHERAPY","RT","Therapy, Radiation",[43],{"name":44,"affiliation":5,"role":45},"Adam Garsa, MD","PRINCIPAL_INVESTIGATOR",[47],{"name":48,"role":49,"phone":50,"phoneExt":26,"email":51},"Christine Duran","CONTACT","323-865-0371","Duran_C@med.usc.edu",[53,74,89,97,114,130,151,168,183],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"City of Hope","RECRUITING","Duarte","California","91010","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-117.97729,34.13945,{"lat":65,"lon":64},[68,72],{"name":69,"role":49,"phone":70,"phoneExt":26,"email":71},"Bianca Del Vecchio","626-218-4402","bdelvecchio@coh.org",{"name":73,"role":45,"phone":26,"phoneExt":26,"email":26},"Savita V Dandapani, MD",{"facility":75,"status":55,"city":76,"state":57,"zip":77,"country":59,"countryCode":60,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Los Angeles General Medical Center","Los Angeles","90033",{"type":62,"coordinates":79},[80,81],-118.24368,34.05223,{"lat":81,"lon":80},[84,88],{"name":85,"role":49,"phone":86,"phoneExt":26,"email":87},"Donna Fernando, RN","323-409-4388","Donna.fernando@med.usc.edu",{"name":44,"role":45,"phone":26,"phoneExt":26,"email":26},{"facility":90,"status":55,"city":76,"state":57,"zip":77,"country":59,"countryCode":60,"cosmosGeoPoint":91,"geoPoint":93,"contacts":94},"USC \u002F Norris Comprehensive Cancer Center",{"type":62,"coordinates":92},[80,81],{"lat":81,"lon":80},[95,96],{"name":85,"role":49,"phone":86,"phoneExt":26,"email":87},{"name":44,"role":45,"phone":26,"phoneExt":26,"email":26},{"facility":98,"status":55,"city":76,"state":57,"zip":99,"country":59,"countryCode":60,"cosmosGeoPoint":100,"geoPoint":102,"contacts":103},"Cedars Sinai Medical Center","90048",{"type":62,"coordinates":101},[80,81],{"lat":81,"lon":80},[104,108,112],{"name":105,"role":49,"phone":106,"phoneExt":26,"email":107},"Chace Henning","310-423-8218","chace.henning@cshs.org",{"name":109,"role":49,"phone":110,"phoneExt":26,"email":111},"Harpavan Sandha","310-423-4849","harpavan.sandha@cshs.org",{"name":113,"role":45,"phone":26,"phoneExt":26,"email":26},"Leslie Ballas, MD",{"facility":115,"status":55,"city":116,"state":117,"zip":118,"country":59,"countryCode":60,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Emory University Hospital\u002FWinship Cancer Institute","Atlanta","Georgia","30322",{"type":62,"coordinates":120},[121,122],-84.38798,33.749,{"lat":122,"lon":121},[125,129],{"name":126,"role":49,"phone":127,"phoneExt":26,"email":128},"Mohammad K. Khan","404-778-3473","Drkhurram2000@gmail.com",{"name":126,"role":45,"phone":26,"phoneExt":26,"email":26},{"facility":131,"status":55,"city":132,"state":133,"zip":134,"country":59,"countryCode":60,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Dana-Farber Cancer Institute","Boston","Massachusetts","02215",{"type":62,"coordinates":136},[137,138],-71.05977,42.35843,{"lat":138,"lon":137},[141,145,149],{"name":142,"role":49,"phone":143,"phoneExt":26,"email":144},"Patrick Boyle","617-582-8918","PJBoyle@dfci.harvard.edu",{"name":146,"role":49,"phone":147,"phoneExt":26,"email":148},"Carol Mayo","508-488-3800","CMAYO@PARTNERS.ORG",{"name":150,"role":45,"phone":26,"phoneExt":26,"email":26},"Andrea K. Ng",{"facility":152,"status":55,"city":153,"state":154,"zip":155,"country":59,"countryCode":60,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"University of Minnesota - Masonic Cancer Center","Minneapolis","Minnesota","55455",{"type":62,"coordinates":157},[158,159],-93.26384,44.97997,{"lat":159,"lon":158},[162,166],{"name":163,"role":49,"phone":164,"phoneExt":26,"email":165},"Kate Bak","612-301-0151","kbak@umn.edu",{"name":167,"role":45,"phone":26,"phoneExt":26,"email":26},"Stephanie Terezakis, MD",{"facility":169,"status":55,"city":170,"state":170,"zip":171,"country":59,"countryCode":60,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Icahn School of Medicine at Mount Sinai","New York","10029",{"type":62,"coordinates":173},[174,175],-74.00597,40.71427,{"lat":175,"lon":174},[178,182],{"name":179,"role":49,"phone":180,"phoneExt":26,"email":181},"Richard L. Bakst","212-241-3545","Richard.bakst@mtsinai.org",{"name":179,"role":45,"phone":26,"phoneExt":26,"email":26},{"facility":184,"status":55,"city":185,"state":186,"zip":187,"country":59,"countryCode":60,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"University of Pennsylvania\u002FAbramson Cancer Center","Philadelphia","Pennsylvania","19104",{"type":62,"coordinates":189},[190,191],-75.16362,39.95238,{"lat":191,"lon":190},[194,198],{"name":195,"role":49,"phone":196,"phoneExt":26,"email":197},"Jhohanna Perez","267-299-9643","RadOncCRU@PennMedicine.upenn.edu",{"name":199,"role":45,"phone":26,"phoneExt":26,"email":26},"John Plastaras, MD, PhD",{"type":201,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[203],{"name":204,"class":205},"National Cancer Institute (NCI)","NIH","100351619","low-dose-radiotherapy-in-treating-painful-bone-metastases-in-patients-with-multiple-myeloma-100351619",false,"NCT03858205","Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma","Phase II Multi-Institutional Study of Low-Dose (2Gy) Palliative Radiotherapy in the Treatment of Symptomatic Bone Metastases From Multiple Myeloma","Inclusion Criteria:\n\n* Histologic diagnosis of multiple myeloma\n* Painful bone metastasis (index lesion) that has a radiographic correlate\n* Patient may have had any number of prior chemotherapy\u002Fimmunotherapy regimens (changes to systemic therapy or use of bisphosphonates for 4 weeks before and after RT are allowed, but recording of these changes must be made so it can be accounted for)\n* Eastern Cooperative Oncology Group (ECOG) 0-2\n* Brief Pain Inventory (BPI) score \\>= 2\n* Ability to understand and the willingness to sign a written informed consent\n\nExclusion Criteria:\n\n* Patients will be ineligible if the index lesion has received prior radiation therapy or prior palliative surgery. Patients may have received prior palliative or primary radiotherapy or surgery to other parts of the body, as long as the index lesion was not in the prior radiation fields and has not received prior palliative surgery\n* Patients will also be ineligible if there is pathologic fracture or impending fracture at the site of the index lesion or planned surgical fixation of the bone at the index lesion\n* Patients with clinical or radiographic evidence of spinal cord or cauda equina compression\u002Feffacement from the index lesion, and\u002For with index lesions located at the skull base or orbital lesions\n* Patients must not be pregnant","ALL","18 Years",{"count":216,"type":217},100,"ESTIMATED","INTERVENTIONAL",[220],"NA","This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiation.",[223,224,225],"Bone Pain","Metastatic Malignant Neoplasm in the Bone","Plasma Cell Myeloma","2026-06-03",{"date":228,"type":229},"2026-06-05","ACTUAL",{"date":231,"type":229},"2019-03-11",{"date":233,"type":217},"2027-03-11",{"name":5,"class":6},9]