[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639092":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":25,"responsibleParty":44,"collaborators":47,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":25,"enrollmentInfo":59,"targetDuration":25,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":75,"whyStopped":25,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":25},{"fullName":5,"class":6},"Bach Mai Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-Dose Rocuronium Maintenance","EXPERIMENTAL","Participants in this group will receive rocuronium for tracheal intubation followed by low-dose rocuronium maintenance during surgery. Rocuronium will be titrated using quantitative train-of-four monitoring to maintain a train-of-four ratio from 0.60 to less than 0.90. All participants will receive standardized total intravenous anesthesia and intraoperative neurophysiological monitoring.",[13],"Drug: Low-Dose Rocuronium Maintenance",{"label":15,"type":16,"description":17,"interventionNames":18},"No Rocuronium Maintenance After Induction","ACTIVE_COMPARATOR","Participants in this group will receive rocuronium for tracheal intubation only. No maintenance rocuronium will be administered after induction. Additional rocuronium may be given only as predefined safety rescue if clinically necessary. All participants will receive standardized total intravenous anesthesia and intraoperative neurophysiological monitoring.",[19],"Drug: Rocuronium",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Rocuronium will be administered for tracheal intubation and then maintained at a low dose during surgery. The infusion will be titrated according to quantitative train-of-four monitoring to maintain a train-of-four ratio from 0.60 to less than 0.90.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Rocuronium","Rocuronium will be administered only for tracheal intubation during induction of anesthesia. No maintenance rocuronium will be administered after induction, except for predefined safety rescue if clinically necessary.",[15],[31],"Rocuronium for Intubation Only",[33],{"name":34,"affiliation":35,"role":36},"Toan Thang Nguyen, MD, PhD, Associate Professor","Hanoi Medical University","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Duc Minh Tran, MD","CONTACT","84869319291","84589916666","tdminh1312@gmail.com",{"type":36,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":35,"oldNameTitle":25,"oldOrganization":25},"Nguyen Toan Thang","Principal Investigator",[48],{"name":35,"class":6},"100639092","low-dose-rocuronium-maintenance-during-spine-surgery-with-intraoperative-neurophysiological-monitoring-100639092",false,"NCT07627750","Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Neurophysiological Monitoring","A Randomized Controlled Trial Comparing Low-Dose Rocuronium Maintenance Versus Discontinuation After Induction on Motor Evoked Potential Quality During Spine Surgery With Intraoperative Neurophysiological Monitoring","ROC-IONM","Inclusion Criteria:\n\n\\- 1. Patients aged 18 years or older. 2. Patients scheduled for spine surgery under general anesthesia. 3. Patients undergoing spine surgery with intraoperative neurophysiological monitoring, including motor evoked potentials and\u002For somatosensory evoked potentials.\n\n4\\. Patients who agree to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* 1\\. Pre-existing central or peripheral neurological disease that may affect intraoperative neurophysiological monitoring, such as quadriplegia, persistent sensory disorder, sequelae of stroke, or polyneuropathy.\n\n  2\\. History of epilepsy or electroencephalographic disorder. 3. Use of neuropsychiatric drugs, strong sedatives, or drugs affecting neuromuscular or neurological conduction within 48 hours before surgery.\n\n  4\\. Decompensated cardiovascular disease or severe respiratory disease that may affect emergence or anesthetic drug metabolism.\n\n  5\\. Contraindication to intraoperative neurophysiological monitoring. 6. Contraindication to rocuronium. 7. Refusal to participate or withdrawal of consent at any time..","ALL","18 Years",{"count":60,"type":61},62,"ESTIMATED","INTERVENTIONAL",[64],"NA","This randomized controlled trial will compare two strategies for rocuronium use during general anesthesia for spine surgery with intraoperative neurophysiological monitoring. Participants undergoing spine surgery under general anesthesia with motor evoked potential and\u002For somatosensory evoked potential monitoring will be randomized to either low-dose rocuronium maintenance targeting a train-of-four ratio of 0.60 to less than 0.90, or no rocuronium maintenance after induction.\n\nThe main objective is to compare the effects of these two strategies on the quality of intraoperative neurophysiological monitoring, especially motor evoked potential signals. Secondary objectives include comparing surgical field conditions, unwanted patient movement, emergence and extubation times, early respiratory events, and new postoperative neurological deficits.\n\nThe study will be conducted at the Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital, Hanoi, Vietnam. The planned sample size is 62 participants, with 31 participants in each group.",[67,68,69],"Spine Surgery","Intraoperative Neurophysiological Monitoring","Neuromuscular Blockade",[27,71,72,73,67,68,74],"Motor Evoked Potentials","Somatosensory Evoked Potentials","Train-of-Four Ratio","Total Intravenous Anesthesia","NOT_YET_RECRUITING","2026-05-30",{"date":78,"type":79},"2026-06-04","ACTUAL",{"date":81,"type":61},"2026-06",{"date":83,"type":61},"2028-12",{"name":5,"class":6}]