[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626832":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":45,"responsibleParty":58,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Kayseri City Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-Flow Sevoflurane Group","ACTIVE_COMPARATOR","In the Low-Flow Sevoflurane Group (DS), a combination of 4 L\u002Fmin fresh gas flow consisting of 50% O₂ and 50% air with 2-3% sevoflurane will be administered during the first 10 minutes. Thereafter, the fresh gas flow will be reduced to 1 L\u002Fmin, and a mixture of 50% O₂ and 50% air with 3-4% sevoflurane will be administered. The concentration of the inhalational anesthetic agents and the rate of remifentanil infusion will be titrated by the attending anesthesiologists to maintain the Bispectral Index (BIS) between 40 and 60, to keep the mean arterial pressure within ±20% of baseline values, and to achieve the age-adjusted minimum alveolar concentration (MAC).",[13],"Drug: Sevoflurane",{"label":15,"type":10,"description":16,"interventionNames":17},"Low-Flow Desflurane Group","In the Low-Flow Desflurane Group (DD), a combination of 4 L\u002Fmin fresh gas flow consisting of 50% O₂ and 50% air with 6% desflurane will be administered for the first 10 minutes. Thereafter, the fresh gas flow will be reduced to 1 L\u002Fmin, and a mixture of 50% O₂ and 50% air with 7-8% desflurane will be administered.\n\nThe concentration of the inhalational anesthetic agent and the rate of remifentanil infusion will be titrated by the attending anesthesiologists to maintain the Bispectral Index (BIS) between 40 and 60, to keep the mean arterial pressure within ±20% of baseline values, and to achieve the age-adjusted minimum alveolar concentration (MAC).",[18],"Drug: Desflurane",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Sevoflurane","Sevoflurane was used for maintenance of general anesthesia under low-flow conditions (fresh gas flow ≤1 L\u002Fmin) during laparoscopic cholecystectomy. Anesthetic depth was adjusted according to standard monitoring and MAC values. The agent will administered until the end of surgery.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Desflurane","Desflurane was used for maintenance of general anesthesia under low-flow conditions (fresh gas flow ≤1 L\u002Fmin) during laparoscopic cholecystectomy. Anesthetic depth was adjusted according to standard monitoring and MAC values. The agent will administered until the end of surgery.",[15],[31],{"name":32,"affiliation":5,"role":33},"Şaziye Burcu Tufanoğulları Erdoğan","PRINCIPAL_INVESTIGATOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Emine Sümeyye Akköze","CONTACT","+903523157700","+905342113708","smyyclk51@gmail.com",{"name":42,"role":37,"phone":38,"phoneExt":43,"email":44},"Şaziye Burcu Tufaoğulları Erdoğan","+905062734602","burcutuf@yahoo.com",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":25,"cosmosGeoPoint":52,"geoPoint":57,"contacts":25},"RECRUITING","Kayseri","Kocasinan","38080","Turkey (Türkiye)",{"type":53,"coordinates":54},"Point",[55,56],35.48528,38.73222,{"lat":56,"lon":55},{"type":33,"investigatorFullName":36,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Research Assistant Doctor","100626832","low-flow-sevoflurane-and-desflurane-anesthesia-in-laparoscopic-cholecystectomy-100626832",false,"NCT07440758","Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy","The Effect of Low-Flow Sevoflurane and Low-Flow Desflurane Anesthesia on Postoperative Sore Throat in Laparoscopic Cholecystectomy Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Aged between 18 and 65 years\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with a recent history of upper respiratory tract infection\n* Patients with a recent history of sore throat\n* Patients with chronic cough\n* Patients with a history of previous neck or tracheal surgery\n* Patients with predictors of difficult intubation\n* Patients with a history of difficult intubation\n* Obese patients (BMI \\> 35 kg\u002Fm²)\n* Patients with chronic respiratory diseases (asthma, COPD)\n* Pregnancy\n* Use of dexamethasone\n* Patients with hepatic impairment\n* Patients with allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide\n* Patients with known allergy to halogenated anesthetic agents\n* Patients with a history of malignant hyperthermia\n* Patients with mental disorders or those unable to provide reliable assessment","ALL","18 Years","65 Years",{"count":71,"type":72},70,"ESTIMATED","INTERVENTIONAL",[75],"NA","Several studies have demonstrated that inhalational anesthetic agents such as desflurane and sevoflurane may cause varying degrees of postoperative sore throat, hoarseness, and cough in orotracheally intubated patients. However, data evaluating these outcomes under low-flow anesthesia conditions remain limited and insufficient.\n\nThis single-center, prospective, randomized controlled study will be conducted in patients aged 18-65 years, classified as American Society of Anesthesiologists (ASA) physical status I-II, who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent to participate in the study.\n\nThe primary objective of the study is to compare the effects of low-flow desflurane and low-flow sevoflurane anesthesia on the incidence and severity of postoperative sore throat.\n\nThe secondary outcomes include the evaluation of postoperative hoarseness and cough, the incidence of postoperative nausea and vomiting (PONV), and the total consumption of inhalational anesthetic agents.",[78,79],"Laparoscopic Cholecystectomy","Postoperative Sore Throat",[81,82,22,27,83,84,85,86,87,88,89],"Postoperative sore throat","Low-flow anesthesia","Laparoscopic cholecystectomy","General anesthesia","Orotracheal intubation","Endotracheal cuff pressure","Postoperative complications","Postoperative nausea and vomiting","PONV","2026-04-24",{"date":92,"type":93},"2026-04-27","ACTUAL",{"date":95,"type":93},"2026-03-20",{"date":97,"type":72},"2026-07-30",{"name":5,"class":6},1]