[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629778":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":27,"locations":38,"responsibleParty":56,"collaborators":21,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":21,"enrollmentInfo":67,"targetDuration":21,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":41,"whyStopped":21,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Fondazione del Piemonte per l'Oncologia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ketogenic Diet Before FDG PET\u002FCT","EXPERIMENTAL","Participants will receive an individualized ketogenic diet for 7 days before undergoing 2-\\[18F\\]FDG PET\u002FCT. The study includes an initial dietary visit, a second dietary evaluation on the day of imaging, laboratory and urine testing, and PET\u002FCT image acquisition.",[13,14],"Behavioral: Ketogenic diet","Diagnostic Test: 2-[18F]FDG PET\u002FCT",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"BEHAVIORAL","Ketogenic diet","Tailored low-glucose\u002Fhigh-fat ketogenic dietary regimen administered for 7 consecutive days before 2-\\[18F\\]FDG PET\u002FCT. Compliance will be assessed by clinical review, laboratory testing, and urinalysis on the day of PET\u002FCT.",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DIAGNOSTIC_TEST","2-[18F]FDG PET\u002FCT","FDG PET\u002FCT performed after completion of the 7-day ketogenic diet. Images will undergo visual and semiquantitative assessment, including comparison of target nodule uptake with mediastinal blood pool background and measurement of SUVmax.",[9],[28,34],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Alessio Rizzo, MD","CONTACT","0119933794","+39","alessio.rizzo@ircc.it",{"name":35,"role":30,"phone":36,"phoneExt":21,"email":37},"Annamaria Nuzzo, PhD","+390119933844","annamaria.nuzzo@ircc.it",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Fondazione del Piemonte per l'Oncologia- IRCCS Istituto di Candiolo, Candiolo, Turin 10060","RECRUITING","Candiolo","Torino (TO)","10060","Italy","IT",{"type":48,"coordinates":49},"Point",[50,51],7.59812,44.95858,{"lat":51,"lon":50},[54],{"name":29,"role":30,"phone":55,"phoneExt":21,"email":33},"+390119933794",{"type":57,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100629778","low-glucosehigh-fat-intake-dietary-regimen-as-a-tool-for-empowering-diagnostic-accuracy-of-2-18ffdg-petct-in-lepidic-predominant-growth-lung-adenocarcinoma-100629778",false,"NCT07479095","Low-glucose\u002FHigh-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET\u002FCT in Lepidic-predominant Growth Lung Adenocarcinoma","KETO-FDG Lung","Inclusion Criteria:\n\n* Written informed consent.\n* Age 18 years or older.\n* CT evidence of a lung nodule suspicious for LPA or lung biopsy positive for LPA.\n* Target nodule diameter at least 10 mm.\n* ECOG performance status 0 to 2.\n* Willingness and ability to adhere to a controlled ketogenic diet for 7 days.\n* Ability to comply with study procedures and visit schedule.\n\nExclusion Criteria:\n\n* Not suitable for prolonged imaging procedures.\n* Renal failure.\n* Type 1 diabetes mellitus.\n* Pancreatitis.\n* Severe dyslipidemia.\n* Other malignancies that are progressing or required active treatment within the previous 3 years.\n* Serious or unstable medical, psychiatric, or substance use disorders that could interfere with study participation.\n* Pregnancy or breastfeeding.\n* Refusal to participate","ALL","18 Years",{"count":68,"type":69},30,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study evaluates whether a 7-day ketogenic dietary regimen before 2-\\[18F\\]FDG PET\u002FCT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET\u002FCT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET\u002FCT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.",[75,76],"Lepidic-Predominant Lung Adenocarcinoma","Lung Adenocarcinoma",[24,78,79,80,81],"Ketogenic Diet","Lepidic Adenocarcinoma","Lung Nodule","Diagnostic Accuracy","2026-03-18",{"date":84,"type":85},"2026-03-20","ACTUAL",{"date":87,"type":85},"2025-07-03",{"date":89,"type":69},"2027-03-30",{"name":5,"class":6},1]