[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643747":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":103,"collaborators":10,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":10,"eligibilityCriteria":112,"healthyVolunteers":109,"sex":113,"minAge":114,"maxAge":10,"enrollmentInfo":115,"targetDuration":10,"studyType":118,"phases":10,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"Hospital Italiano de Buenos Aires","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1: Incidence cohort",null,"Affiliates of the Hospital Italiano Health Plan from January 2011 to December 2023 used to estimate the incidence density of low-grade gliomas.",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort 2: Survival cohort","Histologically confirmed low-grade glioma patients treated at participating centers, followed retrospectively for up to 5 years to assess overall and disease-free survival.",[16],{"name":17,"affiliation":5,"role":18},"Ivan Alfredo Huespe, MD, MPh","STUDY_DIRECTOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","+5493425382554","ivan.huespe@hospitalitaliano.org.ar",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Veronica Ester Monzon, MD","+5491165846854","veronica.monzon@hospitalitaliano.org.ar",[29,48,55,70,82,94],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Hospital Alemán","RECRUITING","Buenos Aires","Buenos Aires F.D.","C1118AAT","Argentina","AR",{"type":38,"coordinates":39},"Point",[40,41],-58.37723,-34.61315,{"lat":41,"lon":40},[44],{"name":45,"role":21,"phone":46,"phoneExt":10,"email":47},"Daniel Ignacio Ivulich, MD","+5491161859413","di.ivulich@gmail.com",{"facility":5,"status":31,"city":32,"state":33,"zip":49,"country":35,"countryCode":36,"cosmosGeoPoint":50,"geoPoint":52,"contacts":53},"C1199ABB",{"type":38,"coordinates":51},[40,41],{"lat":41,"lon":40},[54],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},{"facility":56,"status":31,"city":57,"state":58,"zip":59,"country":35,"countryCode":36,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Hospital Privado Universitario de Córdoba","Córdoba","Córdoba Province","X5016KEH",{"type":38,"coordinates":61},[62,63],-64.18853,-31.40648,{"lat":63,"lon":62},[66],{"name":67,"role":21,"phone":68,"phoneExt":10,"email":69},"Emiliano Tornu, MD","+5491164073575","emilianocornu@gmail.com",{"facility":71,"status":31,"city":32,"state":72,"zip":73,"country":35,"countryCode":36,"cosmosGeoPoint":74,"geoPoint":76,"contacts":77},"Hospital de Alta Complejidad El Cruce - Dr. Néstor Kirchner","Florencio Varela","B1888",{"type":38,"coordinates":75},[40,41],{"lat":41,"lon":40},[78],{"name":79,"role":21,"phone":80,"phoneExt":10,"email":81},"Maximiliano Núñez, MD","+5492216061422","maxineuro@gmail.com",{"facility":83,"status":31,"city":32,"state":84,"zip":85,"country":35,"countryCode":36,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"Hospital Universitario Austral","Pilar","B1629AHJ",{"type":38,"coordinates":87},[40,41],{"lat":41,"lon":40},[90],{"name":91,"role":21,"phone":92,"phoneExt":10,"email":93},"Alicia Gira, MD","+5491126336442","aliciaroxanagira@gmail.com",{"facility":95,"status":31,"city":32,"state":96,"zip":97,"country":35,"countryCode":36,"cosmosGeoPoint":98,"geoPoint":100,"contacts":101},"Hospital Italiano sede San Justo Agustín Rocca","San Justo","C1198AAW",{"type":38,"coordinates":99},[40,41],{"lat":41,"lon":40},[102],{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},{"type":104,"investigatorFullName":105,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ivan A. Huespe","Principal Investigator","100643747","low-grade-gliomas-in-argentina-incidence-survival-and-therapeutic-strategies-100643747",false,"NCT07631338","Low-grade Gliomas in Argentina: Incidence, Survival, and Therapeutic Strategies","Study population cohort 1\n\n* Inclusion Criteria\n\n  * Adult patients (≥18 years old) affiliated to the health plan of Hospital Italiano de Buenos Aires.\n  * Documented clinical follow-up of at least 1 year during the study period.\n* Exclusion Criteria\n\n  * Patients not affiliated to the health plan of the Hospital Italiano de Buenos Aires.\n\nStudy population cohort 2\n\n* Inclusion Criteria\n\n  * Adult patients (≥18 years) with histopathologically confirmed diagnosis of low-grade glioma (WHO grades I and II).\n* Exclusion Criteria\n\n  * Incomplete or doubtful diagnosis based on histopathologic and molecular criteria.","ALL","18 Years",{"count":116,"type":117},40,"ESTIMATED","OBSERVATIONAL","Low-grade gliomas (LGG) are slow-growing primary brain tumors (WHO grades I-II), and their incidence, survival, and treatment patterns in middle-income settings such as Argentina remain poorly characterized. This retrospective, multicenter study comprises two complementary cohorts:\n\n1. Cohort 1: The \"captive\" population covered under the Hospital Italiano de Buenos Aires Health Plan (January 2011-December 2023) to estimate LGG incidence density.\n2. Cohort 2: Histologically confirmed LGG patients treated at the major referral centers to describe overall survival (OS) and disease-free survival (DFS) at 1 and 5 years.\n\nDemographic, clinical, pathological, and treatment data will be collected in a centralized REDCap database.\n\nThe primary objective is to describe LGG incidence in Argentina and estimate survival using Kaplan-Meier curves. The secondary objectives include characterizing therapeutic strategies, molecular mutations, and prognostic factors through Cox regression analysis. This registry will fill a critical gap in LGG epidemiology in middle-income countries and generate hypotheses for future research.",[121],"Low-grade Glioma",[123,124,125,126,127,128],"Low-grade glioma","Glioma","Brain tumor","Neuro-oncology","Incidence","Survival","2026-06-01",{"date":131,"type":132},"2026-06-08","ACTUAL",{"date":134,"type":132},"2026-04-01",{"date":136,"type":117},"2027-05-31",{"name":5,"class":6},6]