[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609855":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":42,"centralContacts":46,"locations":55,"responsibleParty":73,"collaborators":41,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":41,"enrollmentInfo":84,"targetDuration":41,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":58,"whyStopped":41,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Duke University","OTHER",[8,14,18,23,27,31],{"label":9,"type":10,"description":11,"interventionNames":12},"ISPPA- 8 W\u002Fcm^2 (estimated intracranial spatial-peak pulse-average intensities)","EXPERIMENTAL","Participant will receive ultrasound stimulation at intensity of 8 W\u002Fcm\\^2 (estimated intracranial spatial-peak pulse-average intensities, ISPPA).",[13],"Device: Low intensity focused ultrasound stimulation",{"label":15,"type":10,"description":16,"interventionNames":17},"ISPPA- 4 W\u002Fcm^2 (estimated intracranial spatial-peak pulse-average intensities)","Participant will receive ultrasound stimulation at intensity of ISPPA of 4 W\u002Fcm\\^2",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Experimental: ISPPA- 0 W\u002Fcm^2 (estimated intracranial spatial-peak pulse-average intensities)","SHAM_COMPARATOR","Participant will receive ultrasound stimulation at ISPPA- 0 W\u002Fcm\\^2 or sham stimulation",[13],{"label":24,"type":10,"description":25,"interventionNames":26},"Pulse repetition frequency(PRF) at 2000 Hz","each participant will receive LIFUS with pulse repetition frequency at 2000 Hz",[13],{"label":28,"type":10,"description":29,"interventionNames":30},"Pulse repetition frequency(PRF) at 1000 Hz","each participant will receive LIFUS with pulse repetition frequency at 1000 Hz",[13],{"label":32,"type":10,"description":33,"interventionNames":34},"Pulse repetition frequency (PRF) at 500 Hz","Participants will receive LIFUS with pulse repetition frequency at 500 Hz",[13],[36],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"DEVICE","Low intensity focused ultrasound stimulation","A low-intensity focused ultrasound stimulation",[19,15,9,32,28,24],null,[43],{"name":44,"affiliation":5,"role":45},"Wayne Feng, MD MS","PRINCIPAL_INVESTIGATOR",[47,52],{"name":48,"role":49,"phone":50,"phoneExt":41,"email":51},"Clinical Research Coordinator","CONTACT","919-668-7597","megan.gonzalez@duke.edu",{"name":53,"role":49,"phone":41,"phoneExt":41,"email":54},"Ziping Huang, MS","ziping.huang@duke.edu",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Duke University Hospital","RECRUITING","Durham","North Carolina","27710","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-78.89862,35.99403,{"lat":68,"lon":67},[71],{"name":72,"role":49,"phone":50,"phoneExt":41,"email":51},"Megan Gonzalez, MS",{"type":74,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100609855","low-intensity-focused-ultrasound-stimulation-in-stroke-patients---parameter-optimization-100609855",false,"NCT07220005","Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization","LIFUS-OPTIMIZE","Inclusion Criteria:\n\n* age \\>=21 years old of any gender or race\n* First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from the stroke onset of symptoms\n* Unilateral arm weakness measured by the Fugl-Meyer Upper-Extremity Scale ≤ 62\u002F64\n* Inducible rest motor threshold and testing motor threshold recorded from the affected abductor pollicis brevis muscle\n\nExclusion Criteria:\n\n* Bilateral strokes (infarcts and\u002For hematoma)\n* Other co-existent neuromuscular disorders affecting upper extremity motor impairment\n* History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study\n* History of confirmed dementia or taking dementia drugs\n* Uncontrolled hypertension despite medical treatment(s) at the time of enrollment, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and enrolled later)\n* Presence of any MRI\u002FTMS\u002FLIFUS risk factors\n* Concurrent enrollment in another interventional stroke recovery study\n* Concerns that the subject cannot comply with study procedures and visits\n* Pregnant","ALL","21 Years",{"count":85,"type":86},24,"ESTIMATED","INTERVENTIONAL",[89],"NA","The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions.\n\n* with increasing power, would LIFUS be more effective?\n* with the same power, what LIFUS timing is the best\n\nFor Aim 1, the study will compare 8, 4 W\u002Fcm\\^2 to a zero(sham) stimulation to see if higher power is the better.\n\nFor Aim 2, the study will compare 500 vs 1000 vs 2000 Hz \"timing\" to see which one is better.",[92,93,94,95,96],"Stroke","Arm Weakness as a Consequence of Stroke","Upper Extremity Hemiparesis","Upper Extremity Impairments","Upper Extremity Weakness",[98,99,100,101,102,103],"Brain Stimulation","Transcranial Focused Ultrasound Stimulation","Low Intensity Focused Ultrasound Stimulation","Stroke Recovery","Motor Learning","Corticospinal Excitability","2025-12-19",{"date":106,"type":107},"2025-12-23","ACTUAL",{"date":109,"type":107},"2025-12-10",{"date":111,"type":86},"2026-06-30",{"name":5,"class":6},1]