[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531571":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":55,"collaborators":18,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":18,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":18,"enrollmentInfo":67,"targetDuration":18,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Chiang Mai University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-intensity, combined physical-cognitive exercise","EXPERIMENTAL","The exercise program will be prescribed at low intensity for 50 minutes\u002Fsession, 3 times \u002Fweek for 12 consecutive weeks.",[13],"Behavioral: combined physical-cognitive exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Participants will be asked to maintain their routine lifestyle throughout the study period.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","combined physical-cognitive exercise","A combined physical-cognitive exercise will be delivered in the form of exergame, where the participants move their body to interact with the game.",[9],[26],{"name":27,"affiliation":5,"role":28},"S Sungkarat, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"S Kumfu","CONTACT","6653949249","sirintip.ku@up.ac.th",[36],{"facility":37,"status":38,"city":39,"state":18,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University","RECRUITING","Chiang Mai","50200","Thailand","TH",{"type":44,"coordinates":45},"Point",[46,47],98.98468,18.79038,{"lat":47,"lon":46},[50,54],{"name":51,"role":32,"phone":52,"phoneExt":18,"email":53},"Somporn Sungkarat, PhD","+6653-94-9249","somporn.sungkarat@cmu.ac.th",{"name":51,"role":28,"phone":18,"phoneExt":18,"email":18},{"type":28,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Somporn Sungkarat","Associate Professor","100531571","low-intensity-physical-cognitive-exercise-and-cognitive-function-100531571",false,"NCT06201533","Low-intensity Physical-cognitive Exercise and Cognitive Function","Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia","Inclusion Criteria:\n\n* meeting the criteria for MCI (or mNCD) based on the recent DSM-V criteria\n* comprehend instructions and able to comply with the study procedures\n* not taking any medications for their cognition and not planning to start medications during the study trial\n\nExclusion Criteria:\n\n* presence of medical condition(s) unsafe to exercise or affect cognition and mobility\n* presence of depressive symptoms\n* exercise regularly","ALL","60 Years",{"count":68,"type":69},64,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (MCI) and identify the mechanisms by which this exercise protocol exerts cognitive function. Older adults with MCI will be recruited to either an exercise or a control group. Low-intensity, combined physical-cognitive exercise will be prescribed to the exercise group 3 times per week for 3 months while the control group will maintain their routine lifestyle. It is hypothesized that at the end of the trial, participants in the exercise group will demonstrate significant improvement in cognitive performance and circulating biomarkers compared to baseline and the control group.",[75],"Mild Cognitive Impairment",[77,78,79,80],"mild cognitive impairment","low intensity exercise","cognitive function","fibroblast growth factor 21","2026-02-18",{"date":83,"type":84},"2026-02-19","ACTUAL",{"date":86,"type":84},"2024-04-07",{"date":88,"type":69},"2026-03",{"name":5,"class":6},1]