[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100399707":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":35,"responsibleParty":58,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Göteborg University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ICU-patients in ventilator treatment",null,"Directly after intubation and start of mechanical ventilation, a two-PEEP-step up and down procedure with steps of 5-7 cmH2O each is performed and data on airway pressure and tidal volume changes collected. The data is transferred into a dedicated software for calculation of ΔEELV by cumulative difference in expiratory tidal volume before and during PEEP inflation. Consequently, the lung P\u002FV curve from baseline clinical PEEP to end-inspiration of the highest PEEP level. The PEEP level where clinically used tidal volume has the lowest transpulmonary driving pressure is calculated.\n\nA one-PEEP-step procedure with a step of 5-7 cmH2O is performed when clinical events such as disconnection of the breathing circuit, posture changes, suctioning, inhalation, CO2 insufflation etc. is performed, and repeated during the whole period of ventilator treatment.",[13],"Other: PEEP-step method",{"label":15,"type":10,"description":16,"interventionNames":17},"Surgery-patients during general anaesthesia","Directly after intubation and start of mechanical ventilation, a two-PEEP-step up and down procedure with steps of 5-7 cmH2O each, is performed in the same way as described for ICU patients. Data of airway pressure and volumes are transferred into a dedicated software for calculation of ΔEELV by cumulative difference in expiratory tidal volume before and during PEEP inflation. Consequently, the lung P\u002FV curve from baseline clinical PEEP to end-inspiration of the highest PEEP level. The PEEP level where clinically used tidal volume has the lowest transpulmonary driving pressure is calculated.\n\nA one-PEEP-step procedure with a step of 5-7 cmH2O is performed when clinical events such as disconnection of the breathing circuit, posture changes or suctioning is performed, and before and after implementation of pneumoperitoneum.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PEEP-step method","By changing PEEP in one or two steps up and down, transpulmonary pressure and the lung P\u002FV curve can be determined using a dedicated software collecting data on tidal-volume changes and pressure changes during the PEEP-changes from the standard monitoring equipment or ventilator.",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Bengt Nellgård, Prof","Sahlgrenska Academy","STUDY_CHAIR",[29],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Sophie Lindgren, Assoc prof","CONTACT","+46313421000","28587","sophie.lindgren@vgregion.se",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Sophie Lindgren","RECRUITING","Gothenburg","Västra Götaland County","41345","Sweden","SE",{"type":45,"coordinates":46},"Point",[47,48],11.96679,57.70716,{"lat":48,"lon":47},[51,53,56],{"name":52,"role":31,"phone":32,"phoneExt":33,"email":34},"Sophie Lindgren, Ass prof",{"name":54,"role":31,"phone":32,"phoneExt":10,"email":55},"Ali Abdulhussein, MD","ali.abdulhussein@vgregion.se",{"name":54,"role":57,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[61],{"name":62,"class":6},"Sahlgrenska University Hospital","100399707","lung-barometric-measurements-in-normal-and-in-respiratory-distressed-lungs-100399707",false,"NCT04484727","\"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs\"","LUNAR","Inclusion Criteria:\n\n* Patients above18 years\n* ASA 1-3\n* Planned\u002Facute ventilator treatment in ICU or OR\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ASA 4 and above\n* severe COPD\u002Femphysema\u002Fheart failure\n* PEEP\\>16 and\u002For FiO2 \\>80%\n* elevated intracranial pressure\n* defect coagulation\n* non-treated known or suspected pneumothorax","ALL","18 Years",{"count":73,"type":74},200,"ESTIMATED","OBSERVATIONAL","Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and expensive, there are no studies on lung mechanics on intensive care patients directly after intubation, during the first hours of ventilator treatment and forward until the ventilator treatment is withdrawn. Published studies have collected data using the standard methods from day 1 to 3 of ventilator treatment for respiratory system mechanics, i.e. the combined mechanics of lung and chest wall. Consequently, information on lung mechanical properties during the first critical hours of ventilator treatment is missing and individualization of ventilator care done on the basis of respiratory system mechanics, which are not representative of lung mechanics on an individual patient basis. We have developed a PEEP-step method based on a change of PEEP up and down in one or two steps, where the change in end-expiratory lung volume ΔEELV) is determined and lung compliance calculated as ΔEELV divided by ΔPEEP (CL = ΔEELV\u002FΔPEEP). This simple non-invasive method for separating lung and chest wall mechanics provides an opportunity to enhance the knowledge of lung compliance and the transpulmonary pressure. After the two-PEEP-step procedure, the PEEP level where transpulmonary driving pressure is lowest can be calculated for any chosen tidal volume.\n\nThe aim of the present study in the ICU is to survey lung mechanics from start of mechanical ventilation until extubation and to determine PEEP level with lowest (least injurious) transpulmonary driving pressure during ventilator treatment. The aim of the study during anesthesia in the OR, is to survey lung mechanics in lung healthy and identify patients with lung conditions before anesthesia, which may have an increased risk of postoperative complications.",[78,79,80,81,82],"Ventilator-Induced Lung Injury","Ventilatory Failure","Ventilator Lung","Ventilation Therapy; Complications","Ventilator Associated Pneumonia","2025-03-13",{"date":85,"type":86},"2025-03-17","ACTUAL",{"date":88,"type":86},"2022-05-01",{"date":90,"type":74},"2026-12-31",{"name":5,"class":6},1]