[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597721":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":29,"responsibleParty":47,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":20,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":20,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":20,"overallStatus":31,"whyStopped":20,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of California, Irvine","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Low Dose CT Scan of First Degree Relatives of Lung Cancer Patients","EXPERIMENTAL","First degree relatives of patients with lung cancer with a known driver mutation will receive a low dose CT scan of the chest to screen for lung abnormality.",[13],"Diagnostic Test: Low Dose CT Scan",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Low Dose CT Scan","Completed once after screening and eligibility is confirmed.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Chao Family Comprehensive Cancer Center University of California, Irvine","CONTACT","1-877-827-8839","ucstudy@uci.edu",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":20},"University of California Irvine Medical",[30],{"facility":23,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Orange","California","92868","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-117.85311,33.78779,{"lat":41,"lon":40},[44],{"name":45,"role":24,"phone":46,"phoneExt":20,"email":26},"Hari Keshava, MD","877-827-8839",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Hari Keshava","HS Assistant Clinical Professor","100597721","lung-cancer-screening-of-family-members-of-patients-with-mutation-driven-lung-cancer-100597721",false,"NCT07062172","Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer","Cohort A:\n\nInclusion Criteria:\n\n* Current diagnosis of lung cancer with a driver mutation.\n* Known driver mutation (e.g. via NGS, PCR, IHC, FISH, RT-PCR etc.)\n* Able and willing to give informed consent.\n* Able and willing to complete the screening questionnaire.\n\nCohort A:\n\nExclusion Criteria:\n\n* There are no exclusion criteria for Cohort A.\n\nCohort B:\n\nInclusion Criteria:\n\n* Age 40 - 80.\n* Must have a first degree relative (mother, father, sibling, biological child) eligible for Cohort A. Note: Multiple first degree relatives of a Cohort A eligible participant may be approached for participation into the trial.\n* Smoked \\\u003C 20 pack years; a. Pack years = numbers of packs per day × number of years smoked; b. One pack year is the equivalent of smoking an average of 20 cigarettes (1 pack) per day for a year.\n* Be able to undergo a low dose chest CT scan.\n* If an upper respiratory infection (pneumonia, COVID19, flu, etc.) occurred in the last 3 months, this infection must have resolved by time of enrollment.\n* Able and willing to provide informed consent.\n* Able and willing to comply with the protocol requirements\n\nCohort B:\n\nExclusion Criteria:\n\n* Previous history of lung cancers.\n* Symptoms suggestive of presence of current lung cancer, including (but not limited to): unexplained weight loss of over 15 pounds within the last 12 months or unexplained hemoptysis.\n* Pregnant at time of enrollment.\n* History of any type of cancer within 5 years, with the exception of in situ carcinomas and non-melanoma skin cancers (if excised).\n* Current smoker.\n* Smoked ≥ 20 pack years.\n* Had a chest CT scan within 1 year of study entry.","ALL","18 Years","80 Years",{"count":61,"type":62},1753,"ESTIMATED","INTERVENTIONAL",[65],"NA","This is a single-armed screening research study which screens immediate family member of lung cancer patients with a driver mutation to see if lung cancer can be inherited and whether researchers can find lung cancer early. Immediate family members of lung cancer patients will be 40-80 years old and screened using a low dose CT scan.",[68,69],"Lung Cancer","Driver Mutation","2025-07-02",{"date":72,"type":73},"2025-07-14","ACTUAL",{"date":75,"type":73},"2025-05-08",{"date":77,"type":62},"2028-12-31",{"name":5,"class":6},1]