[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100197847":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":57,"centralContacts":62,"locations":72,"responsibleParty":93,"collaborators":10,"id":95,"slug":96,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":10,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":103,"minAge":104,"maxAge":10,"enrollmentInfo":105,"targetDuration":10,"studyType":108,"phases":10,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"University of Florida","OTHER",[8,17,21],{"label":9,"type":10,"description":11,"interventionNames":12},"AAT Deficiency",null,"Those diagnosed with Alpha-1 Antitrypsin (AAT) Deficiency. At every study visit, a history and physical exam (H\\&P), blood draw, and pulmonary function testing (PFTs) with the use of an albuterol inhaler will be done.",[13,14,15,16],"Procedure: History and physical exam.","Procedure: Blood draw.","Procedure: Pulmonary function testing.","Drug: Albuterol inhaler.",{"label":18,"type":10,"description":19,"interventionNames":20},"Cystic Fibrosis","Those diagnosed with Cystic Fibrosis (CF) with mutation Delta F508. At every study visit, a history and physical exam (H\\&P), blood draw, and pulmonary function testing (PFTs) with the use of an albuterol inhaler will be done.",[13,14,15,16],{"label":22,"type":10,"description":23,"interventionNames":24},"Without Lung Disease Diagnosis","Those without the diagnosis of AAT Deficiency or CF. At every study visit, a history and physical exam (H\\&P), blood draw, and pulmonary function testing (PFTs) with the use of an albuterol inhaler will be done.",[13,14,15,16],[26,33,39,45],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","History and physical exam.","At every study visit, participant's will be asked about their medical history and will have a physical exam.",[9,18,22],[32],"H&P",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Blood draw.","At each study visit, participants will have an intravenous catheter (IV) placed in one of their veins and blood will be drawn from the IV for study testing.",[9,18,22],[38],"Phlebotomy",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Pulmonary function testing.","At every study visit, participants will have their lung function assessed. This is done by blowing forcefully at least 3 times into a tube. Testing will be done two times; before and after the use of an Albuterol inhaler.",[9,18,22],[44],"PFTs",{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":50},"DRUG","Albuterol inhaler.","At every study visit, participating subjects will take 2 puffs of an Albuterol inhaler after the first set of PFTs, but before the second set of PFTs. There will be at least a 30 minute period after the use of the Albuterol inhaler and the second set of PFTs.",[9,18,22],[51,52,53,54,55,56],"Ventolin","Proventil","Proventil-HFA","AccuNeb","Vospire","ProAir",[58],{"name":59,"affiliation":60,"role":61},"Karina Serban, MD","University of Florida, College of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine","PRINCIPAL_INVESTIGATOR",[63,68],{"name":64,"role":65,"phone":66,"phoneExt":10,"email":67},"Allison E. Faunce, B.A.","CONTACT","352-273-8666","Allison.Faunce@medicine.ufl.edu",{"name":69,"role":65,"phone":70,"phoneExt":10,"email":71},"Michelle Owens, RN, BSN","352-273-6339","Sandra.Owens@medicine.ufl.edu",[73],{"facility":74,"status":75,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"Shands at the University of Florida","RECRUITING","Gainesville","Florida","32610","United States","US",{"type":82,"coordinates":83},"Point",[84,85],-82.32483,29.65163,{"lat":85,"lon":84},[88,90,92],{"name":89,"role":65,"phone":66,"phoneExt":10,"email":67},"Allison Faunce, B.A.",{"name":91,"role":65,"phone":70,"phoneExt":10,"email":71},"Michelle Owens, RN,BSN",{"name":59,"role":61,"phone":10,"phoneExt":10,"email":10},{"type":94,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100197847","lung-disease-and-its-affect-on-the-work-of-white-blood-cells-in-the-lungs-100197847",false,"NCT01851642","Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs","The Role of Conformational Diseases on Macrophage Function","Inclusion Criteria:\n\n* Signed informed consent\n* Male or female 18 years of age or older\n* Negative pregnancy test for women of childbearing potential\n* Hemoglobin \\>12.5 g\u002Fdl measured on the day of participation\n* Negative urine nicotine test\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Weight \\\u003C 50 kg\n* History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months\n* Known hemoglobin \\\u003C12.5 g\u002Fdl within the past 90 days\n* Systolic blood pressure \\> 180 mmHg and\u002For diastolic blood pressure \\>100 mmHg\n* Poor venous access\n* Large volume blood donation (\\>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)\n* Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)\n* Psychiatric or cognitive disturbance or illness that would affect subject safety\n* Current smoker",true,"ALL","18 Years",{"count":106,"type":107},220,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.",[111,9,112,113],"Alpha-1 Antitrypsin Deficiency","AATD","Cystic Fibrosis (CF)",[115,111,18],"Macrophage","2025-11-05",{"date":118,"type":119},"2025-11-06","ACTUAL",{"date":121,"type":119},"2007-08-09",{"date":123,"type":107},"2033-07-20",{"name":5,"class":6},1]