[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575357":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":20,"locations":28,"responsibleParty":47,"collaborators":7,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":7,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":7,"studyType":62,"phases":7,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":70,"whyStopped":7,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Chile","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"PROCEDURE","Subdural pressure measurement","Subdural intracranial pressure (SDIP) will observed during an alveolar recruitment maneuver and best PEEP titatration. SDIP will be measured while mechanical ventilation is maintained using the identified best PEEP.",[14],"Alveolar recruitment maneuver and decremental PEEP titration",[16],{"name":17,"affiliation":18,"role":19},"Felipe Maldonado, M.D., M.Sc.","Hospital Clinico de la Universidad de Chile","STUDY_CHAIR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":7,"email":24},"CONTACT","+56 2 2978 8221","fmaldonado@uchile.cl",{"name":26,"role":22,"phone":23,"phoneExt":7,"email":27},"Roberto González, M.D.","rgonzalezcor@gmail.com",[29],{"facility":30,"status":7,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Hospital Clínico de la Universidad de Chile","Santiago","Santiago Metropolitan","8380456","Chile","CL",{"type":37,"coordinates":38},"Point",[39,40],-70.64827,-33.45694,{"lat":40,"lon":39},[43,45],{"name":44,"role":22,"phone":7,"phoneExt":7,"email":7},"Felipe Maldonado",{"name":46,"role":22,"phone":7,"phoneExt":7,"email":7},"Roberto González",{"type":48,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100575357","lung-recruitment-and-peep-effects-on-intracranial-pressure-in-cranial-surgery-100575357",false,"NCT06771232","Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery","Impact of Lung Recruitment Maneuvers and Positive End-Expiratory Pressure (PEEP) on Intracranial Pressure in Patients Undergoing Cranial Surgery","Inclusion Criteria:\n\n* ASA classification I-III.\n* Elective cranial neurosurgery.\n\nExclusion Criteria:\n\n* ASA classification IV or higher.\n* Documented intracranial hypertension.\n* Severe pulmonary disease (e.g., asthma, COPD).\n* Emergency surgery.","ALL","18 Years","75 Years",{"count":60,"type":61},20,"ESTIMATED","OBSERVATIONAL","High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.\n\nHowever, individualizing ventilation parameters is essential for each patient. Among protective ventilation strategies, PEEP is key to preventing alveolar collapse. The PEEP level that minimizes alveolar collapse while avoiding overdistension of the pulmonary parenchyma is known as the Best PEEP. This study aims to evaluate the application of Best PEEP in cranial neurosurgery.",[65,66],"Intracranial Pressure Increase","Mechanical Ventilation Complication",[68,69],"Positive end expiratory pressure","intracranial pressure","NOT_YET_RECRUITING","2025-01-09",{"date":73,"type":74},"2025-01-13","ACTUAL",{"date":76,"type":61},"2025-01-01",{"date":78,"type":61},"2026-12-30",{"name":5,"class":6},1]