[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622101":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanically ventilated patients with hypoxemia requiring clinical PEEP optimization",null,"The study will enroll mechanically ventilated patients under sedation\u002Fanalgesia without spontaneous breathing, exhibiting a oxygenation index (PaO₂\u002FFiO₂ ratio) \\\u003C300 mmHg, and deemed clinically eligible for PEEP titration by attending physicians.",[13],"Diagnostic Test: The lung recruitment potential assessed and PEEP titration by ventilator and 2D\u002F3D EIT",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","The lung recruitment potential assessed and PEEP titration by ventilator and 2D\u002F3D EIT","The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R\u002FI ratio), with concurrent monitoring by both 2D- and 3D- EIT.",[9],[21],{"name":22,"affiliation":5,"role":23},"Huaiwu He","STUDY_CHAIR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","010-6915-2300","tjmuhhw@126.com",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences","RECRUITING","Beijing","Beijing Municipality","100730","China","CN",{"type":39,"coordinates":40},"Point",[41,42],116.39723,39.9075,{"lat":42,"lon":41},[45],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622101","lung-recruitment-assessed-by-2d3d-eit-and-ri-ratio-in-acute-respiratory-failure-patients-with-mechanical-ventilation-100622101",false,"NCT07379242","Lung Recruitment Assessed by 2D\u002F3D-EIT and R\u002FI Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Lung Recruitment Assessed by Two-Dimensional\u002FThree-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Inclusion Criteria:\n\n* Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.\n* Oxygenation index \\\u003C 300 mmHg.\n* Patients who are clinically judged by the attending doctor to require the PEEP titration.\n\nExclusion Criteria:\n\n* Aged under 18 years.\n* Pregnancy.\n* Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).\n* No informed consent obtained.\n* Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.\n* High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.","ALL","18 Years",{"count":58,"type":59},50,"ESTIMATED","OBSERVATIONAL","The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R\u002FI ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:\n\nAre the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R\u002FI ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R\u002FI ratios measured at high and low PEEP levels.",[63],"Acute Respiratory Failure (ARF)",[65,66,67,68,69,70],"Acute respiratory failure","PEEP titration","3D-EIT","2D-EIT","Lung recruitability","R\u002FI ratio","2026-01-23",{"date":73,"type":74},"2026-01-30","ACTUAL",{"date":76,"type":74},"2025-09-01",{"date":78,"type":59},"2026-09-30",{"name":5,"class":6},1]