[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571226":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":66,"collaborators":70,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":43,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":43,"enrollmentInfo":82,"targetDuration":43,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":43,"overallStatus":50,"whyStopped":43,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Aretaieion University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MS group","ACTIVE_COMPARATOR","The patients allocated to this group will receive an intravenous bolus of magnesium sulfate (50 mg\u002Fkg) followed by a continuous infusion (15 mg\u002Fkg\u002Fh) Blood coagulation parameters will be assessed pre- and post- magnesium administration using thromboelastometry.",[13],"Drug: Magnesium sulphate",{"label":15,"type":16,"description":17,"interventionNames":18},"NS group","PLACEBO_COMPARATOR","The patients allocated to this group will receive an equivalent volume of normal saline proportionally to the active comparator group. Blood coagulation parameters will be assessed pre- and post-magnesium administration using thromboelastometry.",[19],"Other: Placebo Drug",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Magnesium sulphate","In patients allocated to the MS group, a fixed dose of magnesium sulfate diluted in a fixed volume of natural saline will be administered intravenously.\n\nThromboelastometry will be performed pre and post magnesium administration.",[9],[27],"Thromboelastometry",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo Drug","In patients allocated to the NS group, a fixed dose of natural saline will be administered intravenously, through a fixed volume of solution.\n\nThromboelastometry will be performed pre and post magnesium administration.",[15],[27],[34],{"name":35,"affiliation":36,"role":37},"Kassiani Theodoraki, Professor","Aretaieio University Hospital, National and Kapodistrian University of Athens","STUDY_CHAIR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Marianna Mavromati, MD","CONTACT","0030 6975630647",null,"marimavr14@gmail.com",{"name":35,"role":41,"phone":46,"phoneExt":43,"email":47},"00306974634162","ktheodoraki@hotmail.com",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Athens","Attica","11528","Greece","GR",{"type":57,"coordinates":58},"Point",[59,60],23.72784,37.98376,{"lat":60,"lon":59},[63,65],{"name":40,"role":41,"phone":64,"phoneExt":43,"email":44},"00306975630647",{"name":40,"role":41,"phone":43,"phoneExt":43,"email":43},{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"SPONSOR_INVESTIGATOR","Marianna Mavromati","Marianna Mavromati, MD, Principal Investigator and Anesthesiology Resident, Aretaieion University Hospital, NKUA",[71],{"name":5,"class":6},"100571226","magnesium-sulfate-and-postoperative-hypercoagulability-in-laparoscopic-gynecological-surgeries-100571226",false,"NCT06717490","Magnesium Sulfate and Postoperative Hypercoagulability in Laparoscopic Gynecological Surgeries","Effect of Magnesium Sulfate on Postoperative Hypercoagulability Using Thromboelastometry in Laparoscopic Gynecological Surgeries","Inclusion Criteria:\n\n* ASA I and II patients\n* Laparoscopic gynecological surgeries\n* age \\>18 years\n* Patients receiving prophylactic anticoagulant therapy 12 hours before surgery based on the Caprini score\n* Patients receiving prophylactic anticoagulant therapy 12 hours postoperatively based on the Caprini score.\n\nExclusion Criteria:\n\n* ASA ≥ III\n* age \\\u003C18 years\n* BMI \\>40 kg\u002Fm²\n* Pregnancy\n* Known hematologic disorders\n* Liver\u002Fkidney\u002Fcardiovascular disease\n* Severe anemia (6,5- 7,9 g\u002Fdl)\n* Inability or refusal to provide informed consent",true,"FEMALE","18 Years",{"count":83,"type":84},60,"ESTIMATED","INTERVENTIONAL",[87],"NA","This will be a prospective randomized, double-blind study, aiming at investigating the effects of magnesium sulfate on postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia",[90,27],"Magnesium Sulfate","2024-11-30",{"date":93,"type":94},"2024-12-05","ACTUAL",{"date":96,"type":84},"2024-12",{"date":98,"type":84},"2025-11",{"name":68,"class":6},1]