[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603694":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":27,"locations":10,"responsibleParty":33,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":10,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":50,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"Ondokuz Mayıs University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Magnesium Sulfate Infusion",null,"Patients who underwent elective single-level lumbar microdiscectomy under general anesthesia and received intraoperative magnesium sulfate infusion as part of anesthetic management were included in this group. Magnesium sulfate was administered as a 30 mg\u002Fkg intravenous bolus over 15 minutes after induction, followed by a continuous infusion at 10 mg\u002Fkg\u002Fh until the end of surgery.Intraoperative magnesium sulfate infusion was retrospectively evaluated. Magnesium sulfate had been administered as part of routine anesthetic management and was not an intervention assigned by the investigators for the purpose of this retrospective study.",[13],"Drug: Magnesium Sulfate Infusion",{"label":15,"type":10,"description":16,"interventionNames":17},"0.9% Saline Infusion","Patients who underwent elective single-level lumbar microdiscectomy under general anesthesia and did not receive intraoperative magnesium sulfate infusion were included in this group. These patients were managed with the standard anesthesia protocol.Patients in this group had not received intraoperative magnesium sulfate infusion. Standard anesthetic management was retrospectively evaluated from medical records and was not an intervention assigned by the investigators for the purpose of this retrospective study.",[18],"Drug: 0.9% Saline Infusion",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":10},"DRUG","Magnesium Sulfate (Experimental Group) Intravenous bolus of magnesium sulfate 30 mg\u002Fkg administered over 15 minutes immediately after induction of general anesthesia, followed by continuous infusion at 10 mg\u002Fkg\u002Fh until the end of surgery. Solutions were prepared in identical syringes and infusion bags by an anesthesia technician not involved in patient care. The preparation and administration protocol ensured blinding of participants, anesthesia providers, and outcome assessors.",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":10},"ntravenous bolus and continuous infusion of 0.9% sodium chloride solution in the same volume, infusion rate, and duration as the magnesium sulfate group. Solutions were indistinguishable in appearance and prepared under the same blinding procedures.",[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"İlke tamdoğan, MD","CONTACT","+905062916678","drilkeipek@gmail.com",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ilke Tamdogan","M.D.","100603694","magnesium-sulfate-for-prevention-of-emergence-agitation-in-lumbar-disc-surgery-100603694",false,"NCT07139847","Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery","Effect of Intraoperative Magnesium Infusion on Postoperative Emergence Agitation in Patients Undergoing Lumbar Microdiscectomy","Inclusion Criteria:\n\nAge between 18 and 70 years\n\nASA physical status classification I or II\n\nScheduled for elective single-level lumbar microdiscectomy under general anesthesia\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nSevere cardiovascular disease\n\nHistory of psychiatric disorder\n\nNeuromuscular disease\n\nPregnancy or breastfeeding\n\nHepatic or renal dysfunction\n\nCurrent use of calcium channel blockers, hypnotics, anxiolytics, or antipsychotic medications\n\nKnown allergy to magnesium sulfate or study-related medications\n\nRefusal to participate in the study","ALL","18 Years","70 Years",{"count":48,"type":49},70,"ESTIMATED","1 Month","OBSERVATIONAL","In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under general anesthesia. The medical records of patients aged 18-70 years with an ASA physical status of I-II were retrospectively reviewed. Patients were evaluated according to whether they received intraoperative magnesium sulfate infusion as part of anesthetic management. The primary outcome measure was the incidence of emergence agitation in the post-anesthesia care unit; this assessment was based on Ramsay Sedation Scale scores recorded in the post-anesthesia care unit at admission and at 5, 10, 15, and 30 minutes. Secondary outcome measures included postoperative pain scores assessed using the Numeric Rating Scale, intraoperative remifentanil consumption, recovery and extubation times, tramadol requirement in the post-anesthesia care unit, and possible adverse events related to magnesium infusion.",[54,55,56],"Lumbar Disc Herniation","Emergence Agitation","Magnesium Sulfate",[56,54,58],"Postoperative Complications","NOT_YET_RECRUITING","2026-06-20",{"date":62,"type":63},"2026-06-25","ACTUAL",{"date":65,"type":49},"2026-07-05",{"date":67,"type":49},"2026-09-30",{"name":5,"class":6}]