[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515341":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":39,"locations":48,"responsibleParty":73,"collaborators":28,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":28,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":28,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":50,"whyStopped":28,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Shengjing Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diagnostic (MRE, tumor grade, tumor stiffness and adhesion)","EXPERIMENTAL","Patients undergo a preoperative routine MRI scan and MRE the day before their scheduled surgery to assess tumor stiffness and adhesion. Additionally, molecular pathological analysis will be performed to identify genetic alterations in gliomas. During surgery, the tumor stiffness and adhesion will be assessed and recorded by the surgeon according to established evaluation criteria.\n\nIt is important to note that the surgeon does not have prior knowledge of the tumor's specific stiffness before the surgery. This information is typically obtained through intraoperative assessment and observation.",[13,14],"Diagnostic Test: Magnetic Resonance Elastography","Procedure: Assessment and Recording",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","Magnetic Resonance Elastography","Undergo MRE and routine MRI",[9],[22],"MRE",{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","Assessment and Recording","Undergo recording of tumor stiffness during surgery and molecular pathological classification through genetic analysis",[9],null,[30,33,35,37],{"name":31,"affiliation":5,"role":32},"Yu Shi, MD","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":32},"Anhua Wu, MD",{"name":36,"affiliation":5,"role":32},"Wen Cheng, MD",{"name":38,"affiliation":5,"role":32},"Xiufang A( Ren, MD",[40,44],{"name":31,"role":41,"phone":42,"phoneExt":28,"email":43},"CONTACT","+86 189 4025 9980","18940259980@163.com",{"name":45,"role":41,"phone":46,"phoneExt":28,"email":47},"Yu Zeng, PhD","+86 133 0721 0101","yzengdsg@163.com",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Shenyang","Liaoning","110000","China","CN",{"type":57,"coordinates":58},"Point",[59,60],123.43278,41.79222,{"lat":60,"lon":59},[63,65,68,69,70,71],{"name":31,"role":41,"phone":64,"phoneExt":28,"email":43},"+8618940259980",{"name":34,"role":41,"phone":66,"phoneExt":28,"email":67},"+8618900925766","wuanhua@yahoo.com",{"name":31,"role":32,"phone":28,"phoneExt":28,"email":28},{"name":34,"role":32,"phone":28,"phoneExt":28,"email":28},{"name":36,"role":32,"phone":28,"phoneExt":28,"email":28},{"name":72,"role":32,"phone":28,"phoneExt":28,"email":28},"Xiufang Ren, MD",{"type":32,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Yu Shi","Deputy director of department of radology","100515341","magnetic-resonance-elastography-in-glioma-exploring-tumor-stiffness-and-adhesion-100515341",false,"NCT05990244","Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion","Comprehensive Assessment of Tumor Stiffness and Adhesion in Glioma Using Magnetic Resonance Elastography: A Prospective Study","Inclusion Criteria:\n\n1. age older than 18 years\n2. Karnofsky performance status higher than 60\n3. with written informed consent\n4. MRE performed within one week before surgery\n5. tumor diameter \\> 2 cm\n\nExclusion Criteria:\n\n1. previous treatment for glioma\n2. inability to complete MRE due to intolerance (e.g., vibration-related discomfort or claustrophobia)\n3. completed MRE with suboptimal wave image quality (e.g., motion artifacts or inad-equate wave amplitude)\n4. failure to proceed with surgery after MRE\n5. missing IDH results",true,"ALL","18 Years","80 Years",{"count":88,"type":89},100,"ESTIMATED","INTERVENTIONAL",[92],"NA","this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we aim to explore the correlation of tumor stiffness and adhesion with molecular and genetic characteristics of gliomas. Additionally, the predictive value of MRE in terms of pathological staging and prognosis will be determined. This research may pave the way for improved clinical decision-making, personalized treatment approaches, and more accurate clinical trials for glioma patients.",[95],"Glioma",[18,97,98,99,100],"Brain tumor","Glioblastoma","MR elastography","Tumor molecular pathology","2025-11-24",{"date":103,"type":104},"2025-12-02","ACTUAL",{"date":106,"type":104},"2017-01-01",{"date":108,"type":89},"2027-07-01",{"name":5,"class":6},1]