[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614359":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":66,"collaborators":69,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":25,"eligibilityCriteria":78,"healthyVolunteers":75,"sex":79,"minAge":80,"maxAge":25,"enrollmentInfo":81,"targetDuration":25,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":25,"overallStatus":57,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Tuina + Usual Care","EXPERIMENTAL","Participants will receive Tuina therapy twice weekly for three consecutive weeks (a total of six sessions) in addition to usual care.",[13,14],"Other: Tuina treatment","Other: Usual care",{"label":16,"type":17,"description":18,"interventionNames":19},"Usual Care Only","ACTIVE_COMPARATOR","Participants will receive usual care only for three weeks, no additional manual therapy will be provided.",[14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Tuina treatment","Tuina is a manual therapy involving techniques that apply targeted shear and stretching forces along muscular and fascial planes. Tuina therapy will be administered to subjects twice weekly for three consecutive weeks (a total of six sessions). Each session will last 30-60 minutes and will be administered by licensed Tuina practitioners trained and credentialed at Mayo Clinic.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Usual care","Standard care will be followed, including a patient education course, lifestyle guidance, cognitive-behavioral therapy, and home remedies.",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Ziying Yin, Ph.D.","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Melissa L Bush","CONTACT","507-266-1008","Bush.Melissa1@mayo.edu",[41,55],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":25},"Mayo Clinic in Rochester","ENROLLING_BY_INVITATION","Rochester","Minnesota","55905","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-92.4699,44.02163,{"lat":53,"lon":52},{"facility":56,"status":57,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Mayo Clinic Rochester","RECRUITING",{"type":50,"coordinates":59},[52,53],{"lat":53,"lon":52},[62],{"name":63,"role":37,"phone":64,"phoneExt":25,"email":65},"Melissa Bush","5072661008","bush.melissa1@mayo.edu",{"type":33,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Ziying Yin","Principal Investigator",[70],{"name":71,"class":72},"National Center for Complementary and Integrative Health (NCCIH)","NIH","100614359","magnetic-resonance-elastography-to-monitor-response-to-manual-therapy-in-myofascial-pain-100614359",false,"NCT07278570","Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial Pain","Inclusion Criteria:\n\n* Adult males or females (age ≥ 18 years)\n* A history of chronic low back for at least 3 months. (Measured by patient history and physical exam)\n* A palpable taut band or nodule within the skeletal muscle\n* Hypersensitive tender spot within the taut band\n* Recognition of current pain complaint by pressure on the tender nodule\u002Ftaut band\n* Painful limit to the full stretch range of motion\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Any contraindication to an MRI exam, or severe claustrophobia that would prevent safe completion of the scan\n* Previous therapy in the area to be treated within 3 months\n* Previous severe back injury (including fracture) or surgery\n* Any neurological conditions or active systemic disease (e.g. diabetes, peripheral vascular disease, cancer, rheumatoid arthritis) that impaired sensation\u002Fpain perception\n* Severe osteoarthritis\n* Skin injuries in the area to be treated\n* Inability to provide consent.","ALL","18 Years",{"count":82,"type":83},78,"ESTIMATED","INTERVENTIONAL",[86],"NA","The purpose of this research is to develop and test new Magnetic Resonance Imaging (MRI) methods that look at how muscles and tissues under the skin (myofascial tissues) move and respond to pressure. The investigators want to see how these tissues differ between healthy people and people with pain or injury, and how they change after hands-on treatment (Tuina therapy). The results will also be compared to a group that receives standard care without Tuina therapy.\n\nThe main questions this study aims to answer are:\n\n1. Can MR elastography (MRE) show changes in how the fascia and the layers between muscles move and stretch before and after manual therapy?\n2. Do changes seen on MRE scans match changes in pain, function, and other symptoms reported by participants?\n3. Can MRE measurements before treatment help predict which participants are most likely to improve with manual therapy?\n\nIn this randomized controlled trial, participants with myofascial pain will be randomly assigned (randomized) to either the Tuina group or the Usual Care group following a home-based care program without manual therapy. All treatments are noninvasive, hands-on techniques commonly used in clinical practice to reduce tissue tightness and improve movement.\n\nParticipants will be asked to undergo three MRI scans and to complete questionnaires and other standard clinical assessments about their pain, physical function, and quality of life.",[89,90],"Myofascial Pain Syndrome - Lower Back","Myofascial Pain","2026-02-02",{"date":93,"type":94},"2026-02-03","ACTUAL",{"date":96,"type":94},"2026-02-01",{"date":98,"type":83},"2027-08-30",{"name":5,"class":6},2]