[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560757":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":74,"collaborators":44,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":44,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":44,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":65,"whyStopped":44,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Shanghai Jiao Tong University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Magnetic seizure therapy plus antipsychotics","EXPERIMENTAL","The patients will receive antipsychotic drugs plus MST during the first 2 weeks.\n\nA TwinCoil of MagPro XP will be positioned centrally over the frontal cortex in the midline position. The output power of MagPro XP is set to 100%, and stimulation frequency is 100 Hz. For MST titration, the first step is given at a 5-second train duration; if there is no seizure, the duration is increased to 10 seconds with a maximum limit of 10 seconds. The subsequent MST treatment will be maintained at 10 seconds. This procedure will be carried out under anesthesia.\n\nA total of up to 10 treatments will be administered to participants, usually five times a week, for 2 weeks.",[13],"Device: Magnetic seizure therapy by Magnetic stimulator",{"label":15,"type":16,"description":17,"interventionNames":18},"antipsychotic drugs","ACTIVE_COMPARATOR","The patients will receive second-generation antipsychotic drugs without MST or ECT during the first 2 weeks.",[19],"Drug: Antipsychotic medications (such as olanzpine, risperidone, aripiprazole, quetiapine, amisulpride, etc)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Magnetic seizure therapy by Magnetic stimulator","The seizure is induced by Magnetic stimulator of MagPro MST(XP)，MagVenture A\u002FS, Farum, Denmark. It is administered in combinations with antipsychotic medications",[9],[27],"Seizure therapy",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Antipsychotic medications (such as olanzpine, risperidone, aripiprazole, quetiapine, amisulpride, etc)","It mainly includes second-generation antipsychotic medications, such as olanzpine, risperidone, aripiprazole, quetiapine, amisulpride, etc, but except clozapine.",[15],[34],"antipsychotics",[36],{"name":37,"affiliation":38,"role":39},"Jijun Wang, M.D, Ph.D","Shanghai Mental Health Center","PRINCIPAL_INVESTIGATOR",[41],{"name":37,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","86-21-34773065",null,"jijunwang27@163.com",[47,64],{"facility":38,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"NOT_YET_RECRUITING","Shanghai","Shanghai Municipality","200030","China","CN",{"type":55,"coordinates":56},"Point",[57,58],121.45806,31.22222,{"lat":58,"lon":57},[61,63],{"name":62,"role":42,"phone":44,"phoneExt":44,"email":44},"Jijun Wang, MD, PhD",{"name":44,"role":42,"phone":44,"phoneExt":44,"email":45},{"facility":38,"status":65,"city":49,"state":50,"zip":44,"country":52,"countryCode":53,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},"RECRUITING",{"type":55,"coordinates":67},[57,58],{"lat":58,"lon":57},[70],{"name":71,"role":42,"phone":72,"phoneExt":44,"email":73},"Yawen Hong","86-21-34779305","h1881513@163.com",{"type":39,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Jijun Wang","Professor of Department of Psychiatry","100560757","magnetic-seizure-therapy-for-psychotic-disorders-100560757",false,"NCT06581302","Magnetic Seizure Therapy for Psychotic Disorders","Accelerated 100Hz Magnetic Seizure Therapy for Psychotic Disorders","Inclusion Criteria:\n\n* (1) meets the diagnostic criteria for schizophrenia or other primary psychotic disorders according to DSM-5;\n* (2) age range between 18 and 55 years;\n* (3) Positive And Negative Syndrome Scale (PANSS) score≥60;\n* (4) to provide informed consent.\n\nExclusion Criteria:\n\n* (1) have a concomitant severe medical illness;\n* (2) are pregnant or intend to get pregnant during the study;\n* (3) have a history of DSM-5 diagnosis of substance dependence or abuse within the past three months;\n* (4) history of traumatic brain injury (with a screening scale score of 7 or above);\n* (5) history of poor response to electroconvulsive therapy or MST;\n* (6) have probable dementia based on study investigator assessment; have any significant neurological disorder or condition likely to be associated with increased intracranial pressure or a space occupying brain lesion, e.g., cerebral aneurysm;\n* (7) presenting with a medical condition, medication, or laboratory anomaly deemed by the investigator to potentially induce psychotic symptoms, or significant cognitive impairment. (e.g., hypothyroidism with low TSH, rheumatoid arthritis requiring high dose prednisone, or Cushing's disease);\n* (8) have an intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed;\n* (9) a score of 18 or more on the 24-item Hamilton Depression Rating Scale (HAM-D);\n* (10) needing ECT treatment immediately due to such dangerous symptoms as suicide, stupor or psychomotor agitation, etc.","ALL","18 Years","55 Years",{"count":88,"type":89},50,"ESTIMATED","INTERVENTIONAL",[92],"NA","This trial aims to evaluate the efficacy and safety of Magnetic Seizure Therapy (MST) as an augmentation of antipsychotic medications for psychosis.",[95],"Psychotic Disorders",[97,98,99],"Magnetic Seizure Therapy (MST)","psychotic disorders","longitudinal study","2025-11-24",{"date":102,"type":103},"2025-11-25","ACTUAL",{"date":105,"type":103},"2024-09-01",{"date":107,"type":89},"2025-12-30",{"name":5,"class":6},2]