[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521585":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":24,"locations":32,"responsibleParty":100,"collaborators":103,"id":109,"slug":110,"hasResults":111,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":111,"sex":116,"minAge":117,"maxAge":10,"enrollmentInfo":118,"targetDuration":121,"studyType":122,"phases":10,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Enteral Stenting",null,"Endoscopic placement of enteral Self-Expandable Metal Stents (SEMS). The procedure implies endoscopic identification of the stricture, placement of a guidewire through the stricture and placement of a SEMS through the stricture under fluoroscopic control.",{"label":13,"type":10,"description":14,"interventionNames":10},"EUS-guided Gastrojejunostomy","The procedure implies distention of the jejunal loop and EUS-guided placement of an electrocautery-enhanced (EC) LAMS connecting the stomach to a jejunal loop distal to the stenosis. Any technique for EUS-GE will be allowed, provided that an EC-LAMS \\>15mm will be used.",{"label":16,"type":10,"description":17,"interventionNames":10},"Surgical Gastrojejunostomy","The procedure implies a surgical anastomosis between gastric wall and a jejunal loop. The procedure can be performed either through laparoscopy or open surgery.",[19,22],{"name":20,"affiliation":5,"role":21},"Giuseppe Vanella, MD","PRINCIPAL_INVESTIGATOR",{"name":23,"affiliation":5,"role":21},"Gabriele Capurso, MD",[25,29],{"name":20,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+390226439574","vanella.giuseppe@hsr.it",{"name":30,"role":26,"phone":10,"phoneExt":10,"email":31},"Laura Apadula","apadula.laura@hsr.it",[33,50,64,75,88],{"facility":34,"status":35,"city":36,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Hôpital la pitié salpêtrière, APHP","NOT_YET_RECRUITING","Paris","France","FR",{"type":40,"coordinates":41},"Point",[42,43],2.3488,48.85341,{"lat":43,"lon":42},[46,48],{"name":47,"role":26,"phone":10,"phoneExt":10,"email":10},"Charles De Ponthaud",{"name":49,"role":26,"phone":10,"phoneExt":10,"email":10},"Sebastien Gaujoux",{"facility":51,"status":52,"city":53,"state":10,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"IRCCS San Raffaele Scientific Institute","RECRUITING","Milan","20132","Italy","IT",{"type":40,"coordinates":58},[59,60],9.18951,45.46427,{"lat":60,"lon":59},[63],{"name":20,"role":26,"phone":27,"phoneExt":10,"email":28},{"facility":65,"status":35,"city":66,"state":10,"zip":10,"country":55,"countryCode":56,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"ISMETT - University of Palermo","Palermo",{"type":40,"coordinates":68},[69,70],13.3636,38.1166,{"lat":70,"lon":69},[73],{"name":74,"role":26,"phone":10,"phoneExt":10,"email":10},"Giacomo Rizzo",{"facility":76,"status":35,"city":77,"state":10,"zip":10,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"São João University Hospital","Porto","Portugal","PT",{"type":40,"coordinates":81},[82,83],-8.61097,41.1485,{"lat":83,"lon":82},[86],{"name":87,"role":26,"phone":10,"phoneExt":10,"email":10},"Filipe Vilas Boas Silva",{"facility":89,"status":35,"city":90,"state":10,"zip":10,"country":91,"countryCode":10,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Acibadem Maslak Hospital","Istanbul","Turkey (Türkiye)",{"type":40,"coordinates":93},[94,95],28.94966,41.01384,{"lat":95,"lon":94},[98],{"name":99,"role":26,"phone":10,"phoneExt":10,"email":10},"Bahadir Bozkırlı",{"type":21,"investigatorFullName":101,"investigatorTitle":102,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Giuseppe Vanella","Principal Investigator",[104,107],{"name":105,"class":106},"European Pancreatic Club","UNKNOWN",{"name":108,"class":6},"The Mediterranean Institute for Transplantation and Advanced Specialized Therapies","100521585","management-of-malignant-gastric-outlet-obstruction-between-surgery-and-endoscopy-100521585",false,"NCT06071507","Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy","GOOSE","Inclusion Criteria:\n\n* cyto-\u002Fhisto-logically confirmed pancreatic cancer\n* a maximum of 6 months from pancreatic cancer diagnosis and candidate to active treatment\n* stenosis causing gastric outlet obstruction (GOO) due to neoplastic invasion\u002Fcompression confirmed by radiology or endoscopy extending from the distal one third of the stomach or the duodenum\n* patients candidate to either ES or EUS-GE or s-GE\n\nExclusion Criteria:\n\n* age \\\u003C 18 years\n* patients with benign or indeterminate gastrointestinal stenosis\n* patients with malignant GOO (mGOO) from neoplasia other than pancreatic cancer\n* candidates to upfront surgical resection or who already received curative pancreatic resection\n* patients who already received a treatment for mGOO\n* patients receiving an additional procedure for biliary drainage which might increase the risk of adverse events or hamper the assessment of quality of life; biliary drainage will be allowed if performed uneventfully (without adverse events) at least one day (endoscopic drainage) or one month (surgical hepaticojejunostomy) before mGOO treatment;\n* patients carrying any percutaneous drainage (such as percutaneous transhepatic biliary drainage or ascites drainage).\n* inability or unwillingness to sign the informed consent form (ICF)\n* contraindications to any active palliation of the mGOO, or indication to palliation through venting gastrostomy or nasogastric tube placement alone","ALL","18 Years",{"count":119,"type":120},250,"ESTIMATED","24 Months","OBSERVATIONAL","The aim of this observational study is to compare the outcomes of three different procedures performed for the management of malignant Gastric Outlet Obstruction due to Pancreatic Cancer.\n\nPatients who undergo:\n\n* Surgical gastroenterostomy\n* Endoscopic placement of a self-expanding metallic stent\n* EUS-guided gastroenterostomy in accordance with standard clinical practice, will be enrolled to evaluate potential differences between the procedures in terms of clinical success, eating experience, chemotherapy tolerance, and nutritional status during follow-up.\n\nParticipants will be asked to complete a quality of life questionnaire at baseline and during follow-up; however, no additional procedures will be conducted as a result of participation in the study.",[125,126],"Gastric Outlet Obstruction","Pancreatic Cancer",[128,129,130,131,132,133,134],"Enteral stent","Duodenal stent","Gastroenterostomy","EUS","Bypass","LAMS","Gastrojejunostomy","2026-01-14",{"date":137,"type":138},"2026-01-15","ACTUAL",{"date":140,"type":138},"2024-04-15",{"date":142,"type":120},"2027-12",{"name":5,"class":6},5]