[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592029":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":40,"locations":45,"responsibleParty":71,"collaborators":25,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":25,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":25,"enrollmentInfo":83,"targetDuration":25,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":25,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-invasive Ventilation group","EXPERIMENTAL","NIV Arm\n\n* Device: Bi-level positive airway pressure (BiPAP) via oronasal mask.\n* Initial settings: inspiratory positive airway pressure (IPAP) 10 cmH₂O, expiratory positive airway pressure (EPAP) 5 cmH₂O, and fraction of inspired oxygen (FiO₂) titrated to oxygen saturation (SpO₂) ≥ 92%.\n* Weaning: Decrement IPAP\u002FEPAP by 2 cmH₂O every four hours as tolerated.",[13],"Device: BIPAP",{"label":15,"type":10,"description":16,"interventionNames":17},"High Velocity Nasal Cannula (HVNC) group","HVNC Arm\n\n* Device: Heated, humidified high-flow nasal cannula (HFNC) system.\n* Initial flow: 50 L\u002Fmin, fraction of inspired oxygen (FiO₂) titrated to SpO₂ ≥ 92%.\n* Weaning: Reduce flow by 10 L\u002Fmin every 4 h as tolerated.",[18],"Device: Vapotherm",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","BIPAP","The second arm (NIV group) will be managed by BIPAP device for post-operative respiratory failure",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Vapotherm","The first arm (HVNC group) will be managed by Vapotherm device for post-operative respiratory failure",[15],[31,32],"High-velocity nasal insufflation","High velocity nasal cannula",[34,38],{"name":35,"affiliation":36,"role":37},"Ahmad M. Shaddad, MD","Assuit Univeristy","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":5,"role":37},"Aliae A. Hussien, MD",[41],{"name":35,"role":42,"phone":43,"phoneExt":25,"email":44},"CONTACT","+201111171930","shaddad_ahmad@aun.edu.eg",[46],{"facility":36,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Asyut","Assuit","71515","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.18368,27.18096,{"lat":57,"lon":56},[60,63,64,66,67,69],{"name":61,"role":42,"phone":43,"phoneExt":25,"email":62},"ahmed M. shaddad, MD","shaddad_ahmad@yahoo.com",{"name":25,"role":42,"phone":25,"phoneExt":25,"email":62},{"name":65,"role":37,"phone":25,"phoneExt":25,"email":25},"ahmed M. Shaddad, MD",{"name":39,"role":37,"phone":25,"phoneExt":25,"email":25},{"name":68,"role":37,"phone":25,"phoneExt":25,"email":25},"Maiada K. Hahem, MD",{"name":70,"role":37,"phone":25,"phoneExt":25,"email":25},"Ahmad M. Abd El-Hafez, MD",{"type":37,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Ahmad Shaddad","Associate Professor","100592029","management-of-post-operative-respiratory-failure-by-using-niv-and-high-velocity-nasal-insufflation-hvni-100592029",false,"NCT06988111","Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)","A Prospective, Randomized Controlled Trial Comparing Noninvasive Ventilation (NIV) Versus High-Velocity Nasal Cannula (HVNC) in the Management of Acute Post-Operative Respiratory Failure","Inclusion criteria:\n\n* Age above 18 years\n* within 48 hours after major surgery\n* PAO2\u002FFIO2 less than 200\n* Signs of respiratory distress and respiratory rate (RR) more than 25 cycles\u002Fminute\n\nExclusion Criteria:\n\n* Age below 18 years\n* Pregnant ladies\n* Orofacial trauma or burns\n* Active Gastrointestinal bleeding","ALL","18 Years",{"count":84,"type":85},180,"ESTIMATED","INTERVENTIONAL",[88],"NA","Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.",[91,92,93],"Respiratory Failure Without Hypercapnia","Respiratory Failure With Hypercapnia","Postoperative Respiratory Complication","2026-04-26",{"date":96,"type":97},"2026-04-30","ACTUAL",{"date":99,"type":97},"2025-07-01",{"date":101,"type":85},"2026-12-01",{"name":5,"class":6},1]