[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100362641":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":41,"collaborators":19,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":19,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":19,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Alexandria","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Axially vascularized constructs","EXPERIMENTAL","Reconstructing a mandibular defect using an axially vascularized bone substitute using the arteriovenous loop (AVL)",[13],"Other: Surgical reconstruction of the mandible using an axially vascularized bone construct",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Surgical reconstruction of the mandible using an axially vascularized bone construct","Surgically reconstructing defects of the mandible using reconstruction plate and Titanium mesh filled with an artificial bone substitute to form a bone construct. This construct will be vascularized at the same operation using a vein graft from the forearm. The vein graft will be microsurgically connected to an artery and vein within the facial\u002Fneck region to provide a vascular supply to the construct (arterio venous loop)",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Ahmad M Eweida, MD, PhD","CONTACT","0049 017665232331","ahmad.eweida@alexmed.edu.eg",[27],{"facility":28,"status":29,"city":30,"state":19,"zip":19,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Faculty of Medicine, University of Alexandria","RECRUITING","Alexandria","Egypt","EG",{"type":34,"coordinates":35},"Point",[36,37],29.91582,31.20176,{"lat":37,"lon":36},[40],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Ahmad Mahmoud Eweida","Lecturer of Surgery","100362641","mandibular-reconstruction-with-axially-vascularised-bone-substitutes-100362641",false,"NCT04001842","Mandibular Reconstruction With Axially Vascularised Bone Substitutes","Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes","Inclusion Criteria:\n\n* Patients requiring mandibular reconstruction for further dental rehabilitation\n* Mandibular defect (marginal\u002Fsegmental) equals or more than 6 cm in largest dimension\n* Middle age adult (18-65 years)\n* Radiologically and pathologically documented tumour free mandibular defect\n\nExclusion Criteria:\n\n* Extremes of age (\\\u003C18 or \\> 65 years)\n* Associated uncontrolled chronic illness (Diabetes mellitus, Hypertension, Rheumatoid arthritis, collagen disease, Chronic obstructive pulmonary disease)\n* Primary reconstruction of a mandibular defect after tumour excision","ALL","18 Years","65 Years",{"count":56,"type":57},10,"ESTIMATED","INTERVENTIONAL",[60],"NA","Mandibular reconstruction is necessary following trauma, tumour resections and extensive infections resulting in severe defects of the mandibular arch. For reconstructing large and recurrent defects, the vascularized free flaps are currently regarded as the gold standard. The use of these flaps, however, presents several major inconveniences. Although regenerative medicine in the field of cranio-maxillofacial reconstruction has now become a common practice, the main technical challenge is still related to vascularization of the regenerated tissue in large defects. Axial vascularization of constructs using a microvascular arteriovenous fistula\u002Floop (AV loop) aims at providing the construct with blood supply through a defined and dedicated vascular axis. This technique was successfully demonstrated in some case reports, but was never applied in the craniofacial region. The current study aims to apply and assess the technique of axial vascularization using the AV loop of a bone substitute to reconstruct mandibular defects.",[63],"Mandibular Deficiency",[65,66,67,68,69,70],"Mandibular reconstruction","Mandibular regeneration","Regenerative Medicine","Tissue Engineering","Axial vascularization","Arterio-venous loop","2024-12-03",{"date":73,"type":74},"2024-12-05","ACTUAL",{"date":76,"type":74},"2019-07-01",{"date":78,"type":57},"2030-06-30",{"name":5,"class":6},1]