[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558655":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":38,"locations":44,"responsibleParty":64,"collaborators":31,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":31,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":31,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":31,"overallStatus":46,"whyStopped":31,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Botox injection group","EXPERIMENTAL","Patients will be treated by Botox injection in lateral pterygoid muscle and medications like muscle relaxants, antidepressants, and nonsteroidal anti-inflammatory drugs.\n\nA Botox-A vial was diluted with normal saline to a concentration of 10 U per 0.1 mL for injection in a 1-ml insulin syringe. This will be injected into the ipsilateral lateral pterygoid muscle",[13],"Drug: Botox injection",{"label":15,"type":10,"description":16,"interventionNames":17},"Mandibular stabilization splint group","Patients will be treated by mandibular stabilization splint and medications like muscle relaxants, antidepressants and nonsteroidal anti-inflammatory drugs.",[18],"Drug: Mandibular stabilization splint",{"label":20,"type":21,"description":22,"interventionNames":23},"Control group","ACTIVE_COMPARATOR","Patients will be treated by medications like muscle relaxants, antidepressants and nonsteroidal anti-inflammatory drugs.",[24],"Drug: Muscle relaxant",[26,32,35],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Botox injection","Patients will be treated by Botox injection in lateral pterygoid muscle and medications like muscle relaxants, antidepressants and nonsteroidal anti-inflammatory drugs.\n\nA Botox-A vial was diluted with normal saline to a concentration of 10 U per 0.1 mL for injection in a 1-ml insulin syringe. This will be injected into the ipsilateral lateral pterygoid muscle.",[9],null,{"type":27,"name":33,"description":16,"armGroupLabels":34,"otherNames":31},"Mandibular stabilization splint",[15],{"type":27,"name":36,"description":22,"armGroupLabels":37,"otherNames":31},"Muscle relaxant",[20],[39],{"name":40,"role":41,"phone":42,"phoneExt":31,"email":43},"Kerolos G Abd-El Malak, MBBCH","CONTACT","00201276145151","Kerols.ghobreal@deraya.edu.eg",[45],{"facility":5,"status":46,"city":47,"state":31,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Cairo","11796","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.24967,30.06263,{"lat":55,"lon":54},[58,59,62],{"name":40,"role":41,"phone":42,"phoneExt":31,"email":43},{"name":60,"role":61,"phone":31,"phoneExt":31,"email":31},"Soheir S Rizkallah, MD","SUB_INVESTIGATOR",{"name":63,"role":61,"phone":31,"phoneExt":31,"email":31},"Aya A Khalil, MD",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Kerolos Ghobrial Goda Abd-El Malak","Resident of Physical Therapy , Faculty of Physical Therapy ,Cairo University, Cairo, Egypt.","100558655","mandibular-splint-vs-botox-injection-in-lateral-pterygoid-on-cervical-muscle-activity-in-patients-with-temporomandibular-disorders-100558655",false,"NCT06553950","Mandibular Splint vs Botox Injection in Lateral Pterygoid on Cervical Muscle Activity in Patients With Temporomandibular Disorders","Mandibular Splint Versus Botox Injection in Lateral Pterygoid on Cervical Muscle Activity in Patients With Temporomandibular Disorders","Inclusion Criteria:\n\n* Age from 18-40 years old.\n* Both sexes.\n* Duration of the disease is more than 3 months.\n* Anterior mandibular disc displacement with reduction will be included.\n* Unilateral anterior mandibular displacement with reduction grade 2\\&3 (Wilkes) will be included.\n* Patients with cervical muscles spasm and trigger points (upper trapezius\\& sternocleidomastoid) will be included.\n* Patients with sufficient cognitive abilities that enables them to understand and follow instructions.\n\nExclusion Criteria:\n\n* Neurological or musculoskeletal diseases that affect cervical spine other than mandibular disc displacement (eg: cervical spondylosis, spondylolisthesis, and cervical disc injuries)\n* Bilateral anterior mandibular disc displacement patients.\n* Musculoskeletal disorders such as severe arthritis, cervical spine surgery or contractures of fixed deformity, leg length discrepancy.\n* women during pregnancy and lactation.\n* Patients with known hypersensitivity to any component of the drug (especially hypersensitivity to human albumin).\n* Patients with infection or inflammation of the area where the toxin injections are planned, in patients with musculoskeletal conduction disorders, in primary muscular disorders (muscular dystrophy, neuromyopathy, congenital myopathies, myotonic disorders, mitochondrial myopathy and unspecified or other primary muscle disorders).\n* Patients being treated with aminoglycoside antibiotics, ciclosporin, D-penicillamine, tubocurarine, pancuronium, gallamine, succinylcholine, chloroquine, or hydroxychloroquine.\n* History of cervical spine surgery.\n* History of trauma or fractures in cervical spine.\n* Signs of cervical radiculopathy or myelopathy.\n* Vascular syndrome such as vertebrobasilar insufficiency.\n* Signs of serious pathology ( e.g., malignancy, inflammatory disorders, infection).","ALL","18 Years","40 Years",{"count":79,"type":80},33,"ESTIMATED","INTERVENTIONAL",[83],"NA","The study aims to compere mandibular splint versus botox injection in lateral pterygoid on cervical muscle activity in patients with temporomandibular disorders",[86,87,88,89,90],"Mandibular Splint","Botox","Lateral Pterygoid","Cervical Muscle Activity","Temporomandibular Disorders","2024-08-14",{"date":93,"type":94},"2024-08-16","ACTUAL",{"date":91,"type":94},{"date":97,"type":80},"2025-02-01",{"name":5,"class":6},1]