[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638458":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":38,"responsibleParty":56,"collaborators":24,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":40,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Ankara Etlik City Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mean Arterial Pressure-Guided Hemodynamic Management","ACTIVE_COMPARATOR","Patients in this group will receive intraoperative hemodynamic management based on predefined mean arterial pressure targets. Hemodynamic interventions, including fluid administration, vasopressor therapy, and other standard intraoperative management strategies, will be guided primarily by mean arterial pressure values.",[13],"Procedure: Mean Arterial Pressure-Guided Hemodynamic Management",{"label":15,"type":10,"description":16,"interventionNames":17},"Cardiac Index-Guided Hemodynamic Management","Patients in this group will receive intraoperative hemodynamic management based on predefined cardiac index targets. Hemodynamic interventions, including fluid administration, vasopressor or inotrope therapy, and other standard intraoperative management strategies, will be guided primarily by cardiac index values.",[18],"Procedure: Cardiac Index-Guided Hemodynamic Management",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Intraoperative hemodynamic management will be performed according to predefined mean arterial pressure targets during pancreaticoduodenectomy. Standard anesthetic care, fluid therapy, vasopressor use, and intraoperative monitoring will be applied according to institutional clinical practice.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Intraoperative hemodynamic management will be performed according to predefined cardiac index targets during pancreaticoduodenectomy. Cardiac index values will be monitored intraoperatively, and fluid therapy, vasopressor use, and inotrope administration will be adjusted according to the hemodynamic status of the patient and institutional clinical practice.",[15],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Atakan Sezgi","CONTACT","00905323327000","kansezgi@gmail.com",{"name":35,"role":31,"phone":36,"phoneExt":24,"email":37},"Musa Zengin","00905307716235","musazengin@gmail.com",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":24,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Çankaya","Ankara","06170","Turkey (Türkiye)",{"type":46,"coordinates":47},"Point",[48,49],32.86268,39.9179,{"lat":49,"lon":48},[52,54],{"name":53,"role":31,"phone":32,"phoneExt":24,"email":33},"Atakan Sezgi, M.D.",{"name":55,"role":31,"phone":36,"phoneExt":24,"email":37},"Musa Zengin, Associate Professor",{"type":57,"investigatorFullName":30,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100638458","map--versus-cardiac-index-guided-hemodynamic-management-in-whipple-surgery-100638458",false,"NCT07603336","MAP- Versus Cardiac Index-Guided Hemodynamic Management in Whipple Surgery","Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Pancreaticoduodenectomy: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with American Society of Anesthesiologists physical status II-III\n* Patients with estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.73 m²\n* Patients scheduled for pancreaticoduodenectomy \u002F Whipple procedure\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 80 years\n* Patients with estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients with American Society of Anesthesiologists physical status other than II-III\n* Patients who refuse to participate in the study\n* Patients who withdraw consent at any stage of the study","ALL","18 Years","80 Years",{"count":70,"type":71},60,"ESTIMATED","INTERVENTIONAL",[74],"NA","This prospective randomized study aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing pancreaticoduodenectomy. Patients will be allocated to either mean arterial pressure-guided hemodynamic management or cardiac index-guided hemodynamic management during surgery.\n\nPancreaticoduodenectomy is a major abdominal surgical procedure associated with prolonged operative duration, considerable fluid shifts, blood loss, and hemodynamic instability. These factors may contribute to impaired renal perfusion and postoperative renal dysfunction. Although mean arterial pressure is commonly used to guide intraoperative hemodynamic management, blood pressure alone may not fully reflect systemic blood flow or tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy.\n\nThe primary outcome of the study is the change in serum creatinine level from the preoperative baseline value to the postoperative 72nd hour. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, length of intensive care unit and hospital stay, and 30-day mortality.",[77,78],"Whipple Procedure","Intraoperative Hemodynamic Management",[80,81,82,83],"Whipple procedure","Cardiac index","Mean arterial pressure","Hemodynamic management","2026-05-27",{"date":86,"type":87},"2026-05-28","ACTUAL",{"date":84,"type":87},{"date":90,"type":71},"2027-12-28",{"name":5,"class":6},1]