[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623973":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":81,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Anhui Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Dual-target cTBS","EXPERIMENTAL","Participants will receive active continuous Theta Burst Stimulation (cTBS) guided by a neuronavigation system. The stimulation targets are the left auditory association cortex followed by the primary motor cortex (M1). Treatment will be administered three times a day for seven consecutive days.",[13],"Device: Active Dual-target cTBS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Dual-target cTBS","SHAM_COMPARATOR","Participants will undergo a sham cTBS procedure using a placebo coil. The procedure mimics the sound, sensation, and coil placement (dual-target) of the active group but delivers no effective magnetic field.",[19],"Device: Sham Dual-target cTBS",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","A non-invasive brain stimulation technique using a MagStim Rapid2 stimulator with a 70mm air-cooled figure-of-eight coil.\n\nTargets: 1. Left auditory association cortex (MNI: -62, -40, 10), located using Brainsight neuronavigation. 2. Primary Motor Cortex (M1), determined by the resting motor threshold (RMT) hotspot. Protocol: Stimulation of the auditory cortex is immediately followed by M1 stimulation. Each target receives a standard cTBS protocol (3-pulse 50 Hz bursts repeated at 5 Hz, total 600 pulses, 40s duration). Dosing: Delivered at 100% RMT. Sessions are repeated 3 times\u002Fday with 15-min intervals for 7 days.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"A placebo procedure using an inert sham coil that is identical in appearance and sound to the active coil but does not deliver a significant magnetic field to the cortex. Blinding: The procedure includes identical neuronavigation setup, dual-target coil positioning (Auditory Cortex then M1), duration, and treatment schedule (3 times\u002Fday for 7 days) to maintain the blind.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Kai Wang, PhD","CONTACT","+86-0551-62923704","wangkai1964@126.com",[36],{"facility":5,"status":25,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Hefei","Anhui","230000","China","CN",{"type":43,"coordinates":44},"Point",[45,46],117.28083,31.86389,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","WANG KAI","Professor","100623973","mapsd-dual-target-ctbs-auditory-cortex-and-m1-for-generalized-anxiety-disorder-100623973",false,"NCT07403591","Mapsd Dual-target cTBS (Auditory Cortex and M1) for Generalized Anxiety Disorder","Efficacy and Neural Mechanisms of Neuroimage-guided Dual-target Continuous Theta Burst Stimulation (Auditory Cortex and M1) for Generalized Anxiety Disorder","Dual-ACM1-GAD","Inclusion Criteria:\n\n1. Diagnosis of Generalized Anxiety Disorder (GAD) according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), confirmed by at least two psychiatrists.\n2. Hamilton Anxiety Rating Scale (HAMA) score \\> 14.\n3. Age between 18 and 60 years.\n4. Right-handed.\n5. More than 5 years of education.\n6. Patients are either medication-free or maintain a consistent medication regimen during cTBS treatment.\n7. Willing and able to provide written informed consent.\n8. Normal or corrected-to-normal visual acuity and hearing.\n\nExclusion Criteria:\n\n1. Presence of other psychiatric disorders, such as substance abuse, schizophrenia, schizoaffective disorder, hysteria, autism, or bipolar disorder.\n2. History of epilepsy, seizures, or severe neurological diseases (e.g., stroke, organic brain lesions).\n3. Presence of severe somatic diseases, such as severe heart, liver, or renal insufficiency.\n4. Pregnant or lactating women.\n5. Contraindications to Transcranial Magnetic Stimulation (TMS) or Magnetic Resonance Imaging (MRI), such as the presence of a cardiac pacemaker, cochlear implant, cerebrovascular metal stent, or metal dentures.\n6. Inability to cooperate with experimental procedures due to conditions such as severe claustrophobia.","ALL","18 Years","60 Years",{"count":66,"type":67},60,"ESTIMATED","INTERVENTIONAL",[70],"NA","The purpose of this study is to investigate the effectiveness of a dual-target non-invasive brain stimulation technique called continuous Theta Burst Stimulation (cTBS) for treating Generalized Anxiety Disorder (GAD). The researchers will use a neuronavigation system, which acts like a GPS for the brain, to guide the stimulation to two specific targets: the left auditory association cortex and the primary motor cortex (M1).\n\nParticipants will be randomly assigned to one of two groups. One group will receive active dual-target cTBS treatment, while the other will receive a sham (placebo) stimulation that feels similar but has no therapeutic effect. The treatment will be given three times a day for seven consecutive days. Before and after the treatment period, all participants will complete clinical questionnaires to measure their anxiety and undergo Magnetic Resonance Imaging (MRI) scans to help researchers understand how cTBS affects brain activity.",[73],"Generalized Anxiety Disorder",[73,75,76,77,78,79,80],"Continuous Theta Burst Stimulation","Transcranial Magnetic Stimulation","Neuronavigation","Dual-target","Auditory Cortex","Primary Motor Cortex","NOT_YET_RECRUITING","2026-02-04",{"date":84,"type":85},"2026-02-11","ACTUAL",{"date":87,"type":67},"2026-03-01",{"date":89,"type":67},"2027-04-01",{"name":5,"class":6},1]