[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623534":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":26,"locations":10,"responsibleParty":32,"collaborators":10,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":10,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":10},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Peri-implantitis Group",null,"Patients with at least one dental implant in function for at least 1 year, showing signs of inflammation (BOP\u002Fsuppuration), probing depth (PD) ≥ 5 mm, and radiographic bone loss ≥ 2 mm.",{"label":13,"type":10,"description":14,"interventionNames":10},"Periodontitis Group","Patients with at least one tooth having clinical probing depth ≥ 4 mm, presence of bleeding on probing (BOP), and evidence of radiographic alveolar bone loss.",{"label":16,"type":10,"description":17,"interventionNames":10},"Peri-implant Health Group","Patients with implants in function for at least 1 year, showing no signs of inflammation (no BOP), probing depth ≤ 3 mm, and no radiographic bone loss.",{"label":19,"type":10,"description":20,"interventionNames":10},"Periodontal Health Group","Systemically healthy individuals with clinical probing depths ≤ 3 mm, minimal plaque and bleeding scores, and no radiographic evidence of bone loss.",[22],{"name":23,"affiliation":24,"role":25},"Gülbahar Ustaoğlu, Professor","University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Nurullah Yurdakul, Dr.","CONTACT","+905340757662","nurullah.yurdakul@sbu.edu.tr",{"type":25,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Gülbahar Ustaoğlu","Professor","100623534","markers-of-bone-destruction-and-oxidative-stress-in-peri-implantitis-100623534",false,"NCT07397884","Markers of Bone Destruction and Oxidative Stress in Peri-implantitis","Evaluation of Bone Destruction and Oxidative Stress Markers in Saliva and Peri-implant Sulcus Fluid in Peri-implantitis","Inclusion Criteria:\n\nSystemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration.\n\nFor Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss.\n\n(According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) -\n\nExclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis).\n\nUse of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months.\n\nPregnancy or breastfeeding.\n\nSmoking (current smokers).\n\nHistory of periodontal or peri-implant surgical treatment within the last 6 months.\n\nImplant failure (mobility).\n\nSigns of acute infection (fever, systemic symptoms).\n\n\\-",true,"ALL","18 Years","65 Years",{"count":47,"type":48},80,"ESTIMATED","OBSERVATIONAL","The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.",[52,53],"Periodontal Diseases","Periimplant Diseases",[52,55,56,57],"periimplant diseases","Oxidative Stress","Alveolar Bone Loss","NOT_YET_RECRUITING","2026-02-02",{"date":61,"type":62},"2026-02-09","ACTUAL",{"date":64,"type":48},"2026-02-15",{"date":66,"type":48},"2026-09-15",{"name":5,"class":6}]