[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100350076":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":33,"locations":43,"responsibleParty":71,"collaborators":10,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":10,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":10,"studyType":87,"phases":10,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Inpatients",null,"Observation and measure of trajectory of recovery in CRPS. This group will include children diagnosed with CRPS and undergoing regular therapy at the inpatient FIRST clinic at CCHMC and one of their parents or legal guardian.",[13],"Behavioral: observation and measure of trajectory of recovery in CRPS",{"label":15,"type":10,"description":16,"interventionNames":17},"Outpatients","Observation and measure of trajectory of recovery in CRPS. This group will include children diagnosed with CRPS and undergoing regular therapy at the outpatient Pain Management Center at CCHMC and one of their parents or legal guardian.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy Controls","For comparison purposes, healthy controls and one of their parents or legal guardian will be enrolled in this study as well.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"BEHAVIORAL","observation and measure of trajectory of recovery in CRPS","Child participants enrolled in this study will undergo three sessions, which will include psychosocial measures, brain imaging, and quantitative sensory testing. Parent participants will also complete three sessions, which only include psychosocial measures.",[19,9,15],[29],{"name":30,"affiliation":31,"role":32},"Robert C Coghill, PhD","Children's Hospital, Cincinnati","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Marie-Eve Hoeppli, PhD","CONTACT","(513)803-1164","marie-eve.hoeppli@cchmc.org",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},"Geraldine Schulze, BSc","(513) 517-0593","Geraldine.Schulze@cchmc.org",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Cincinnati Children's Hospital Medical Center","RECRUITING","Cincinnati","Ohio","45229","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-84.51439,39.12711,{"lat":56,"lon":55},[59,62,64,67,69],{"name":60,"role":36,"phone":61,"phoneExt":10,"email":42},"Geraldine Schulze","513-517-0593",{"name":35,"role":36,"phone":63,"phoneExt":10,"email":38},"(513) 803-1164",{"name":65,"role":66,"phone":10,"phoneExt":10,"email":10},"Sara E Williams, PhD","SUB_INVESTIGATOR",{"name":68,"role":66,"phone":10,"phoneExt":10,"email":10},"Kenneth R Goldschneider, MD",{"name":70,"role":66,"phone":10,"phoneExt":10,"email":10},"John B Rose, MD",{"type":72,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100350076","markers-of-trajectory-in-pediatric-crps-100350076",false,"NCT03838107","Markers of Trajectory in Pediatric CRPS","Identifying Markers of Trajectory in Pediatric Complex Regional Pain Syndrome","Inclusion Criteria:\n\nAll Children:\n\n* Age between 10 and 17 years old\n* Fluent in English\n\nInpatients:\n\n* Diagnosis of CRPS\n* Former unsuccessful treatment for CRPS\n* Scheduled for or beginning the usual inpatient treatment for CRPS at the FIRST clinic at CCHMC.\n\nOutpatients:\n\n* Diagnosis of CRPS\n* Scheduled for or beginning the usual outpatient treatment for CRPS at the pain management clinic\n\nHealthy children:\n\n\\- No diagnosis of chronic pain.\n\nParents:\n\n* Fluent in English\n* Child participating in the study\n\nExclusion Criteria:\n\nAll child participants:\n\n* Weight\u002Fsize incompatible with MRI scanner\n* Identification of brain, neurologic, or severe psychiatric abnormalities beyond those normally associated with chronic pain.\n* Documented developmental delays or impairment\n* Any MRI contra-indication, including\n* Braces, stents, clips, pace-maker or other metal implants affecting the safety of the participants in the scanner and\u002For the quality of the images\n* pregnancy\n* claustrophobia",true,"ALL","10 Years","17 Years",{"count":85,"type":86},126,"ESTIMATED","OBSERVATIONAL","Complex Regional Pain Syndrome (CRPS) is a severe and complex chronic pain condition in children. Many psychosocial factors impact its development and recovery. CRPS has a strong central component, which is reflected by structural and functional changes in the brain. However, the interaction between these cerebral changes and trajectory of recovery has been seldom investigated to date. Furthermore, interactions between cerebral changes and psychosocial factors, which might affect trajectory of recovery, are unknown. The aim of this study is to identify the psychosocial factors and cerebral changes that predict the trajectory of recovery from CRPS.\n\nChildren between the ages of 10 and 17 years will be enrolled with one of their parents or legal guardians for this study. Three populations will be recruited: patients with CRPS undergoing treatment at the Functional Independence Restoration Program (FIRST), patients with CRPS undergoing treatment at the Pain Management Center and matching healthy controls. Participants will undergo three sessions: the first session will be scheduled immediately before or as soon as possible at the beginning of the patients' treatment; the second session will take place at the end of the patients' treatment; the last session will be scheduled six months post-treatment. The timing of the sessions of the healthy participants will follow a schedule similar to the FIRST patients. Each session will last approximately three hours and include acquisition of psychosocial, psychophysical, and brain imaging data in the child participants, as well as acquisition of psychosocial data in the parent participants.",[90],"Complex Regional Pain Syndromes",[92,93,94,95,96],"pediatric complex regional pain syndrome","fMRI","psychosocial","quantitative sensory testing","markers","2024-02-05",{"date":99,"type":100},"2024-02-07","ACTUAL",{"date":102,"type":100},"2018-08-27",{"date":104,"type":86},"2026-08-31",{"name":5,"class":6},1]